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thielavin B

Product Name
thielavin B
CAS No.
71950-67-9
Chemical Name
thielavin B
Synonyms
thielavin B;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-methoxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester
CBNumber
CB81400007
Formula Weight
0
MOL File
71950-67-9.mol
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thielavin B Property

storage temp. 
-20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble
form 
White to off-white powder.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00566
Product name
Thielavin B
Purity
≥95% (LC/MS-UV)
Packaging
1mg
Price
$747
Updated
2025/07/31
Cayman Chemical
Product number
18770
Product name
Thielavin B
Purity
≥95%
Packaging
500μg
Price
$364
Updated
2024/03/01
Cayman Chemical
Product number
18770
Product name
Thielavin B
Purity
≥95%
Packaging
2.5mg
Price
$1088
Updated
2024/03/01
Usbiological
Product number
T5006-50A
Product name
Thielavin B
Packaging
500ug
Price
$582
Updated
2021/12/16
Usbiological
Product number
467494
Product name
Thielavin B
Packaging
500ug
Price
$644
Updated
2021/12/16
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thielavin B Chemical Properties,Usage,Production

Description

Thielavin B is a fungal metabolite that contains O-substituted salicylic acid. It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid to Prostaglandin H2 (PGH2) and the conversion of PGH2 to PGE2 (, IC50s = 40 and 9 μM, respectively). Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity.

Uses

Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis.

Uses

Thielavin B is a fungal metabolite of?Thielavia terricola that contains O-substituted salicylic acid. It is an inhibitor of viral reverse transcriptase and telomerase.

General Description

Natural product derived from fungal source.

References

[1] N MANI. Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus.[J]. Journal of Antibiotics, 1998, 51 5: 471-479. DOI: 10.7164/antibiotics.51.471
[2] KEN-ICHI TOGASHI. Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B[J]. Bioscience, Biotechnology, and Biochemistry, 2001, 65 1: 651-653. DOI: 10.1271/bbb.65.651

thielavin B Preparation Products And Raw materials

Raw materials

Preparation Products

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71950-67-9, thielavin BRelated Search:

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  • thielavin B
  • 4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-methoxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester
  • 71950-67-9