ChemicalBook > CAS DataBase List > Nefazodone hydrochloride

Nefazodone hydrochloride

Product Name
Nefazodone hydrochloride
CAS No.
82752-99-6
Chemical Name
Nefazodone hydrochloride
Synonyms
TFA ≥Serazone;NEFAZODONE;Isatin ≥Indole ≥BMY 13754-1;Hecameg ≥>=98% (HPLC);Chromone ≥Piperine &ge
CBNumber
CB8144863
Molecular Formula
C25H33Cl2N5O2
Formula Weight
506.47
MOL File
82752-99-6.mol
More
Less

Nefazodone hydrochloride Property

Melting point:
186-188°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: ~11 mg/mL at 60 °C
form 
solid
color 
white
λmax
248nm(MeOH)(lit.)
Merck 
14,6438
CAS DataBase Reference
82752-99-6(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
22-24/25
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
XZ5483009
HS Code 
2933595960
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5536
Product name
Nefazodone hydrochloride
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$173
Updated
2025/07/31
Sigma-Aldrich
Product number
5.08148
Product name
Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem
Packaging
10mg
Price
$135
Updated
2025/07/31
Sigma-Aldrich
Product number
1457902
Product name
Nefazodone hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$1030
Updated
2025/07/31
TCI Chemical
Product number
N1030
Product name
Nefazodone Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
N1030
Product name
Nefazodone Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$89
Updated
2024/03/01
More
Less

Nefazodone hydrochloride Chemical Properties,Usage,Production

Description

Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT2 receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HTIA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a1 -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.

Chemical Properties

White Solid

Originator

Bristol-Myers Squibb (U.S.A.)

Uses

An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor

Uses

A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.

Definition

ChEBI: Nefazodone hydrochloride is a hydrochloride. It contains a nefazodone.

Manufacturing Process

Manufacturing process for Moxifloxacin hydrochloride includes these steps as follows: 1. synthesis of 1-(3-Chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride, 1-(3-Chlorophenyl)-4-(hydrazinopropyl)piperazine. 2.Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling 3.Phenoxypropionyl chloride (9.23 g, 0.05 mol) is dissolved in 100 ml acetone and cooled with an ice bath as sodium azide (3.6 g, 0.055 mol) in 10 ml water is added dropwise. After addition is completed, the reaction mixture is warmed to room temperature and stirred for 30 minutes. The solution is decanted and concentrated. The residue is dissolved in 100 ml ether and washed with saturated sodium bicarbonate and brine. The organic phase is separated, dried (MgSO4) and concentrated to give 6.52 g (68.0% yield) of phenoxypropionyl azide as a yellow oil which solidifies on cooling. 4.Synthesis of Ethyl phenoxypropionate, Phenoxypropionyl hydrazide, Phenoxyethyl isocyanate, 2-3-(4-[3-Chlorophenyl]-1-piperazinyl)propyl]-4-(2-phenoxyethyl)- semicarbazide), and 2-[3-4-(3-Chlorophenyl)-1-piperazinyl]-propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one monohydrochloride (Nefazodone monohydrochloride).

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

General Description

Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.

Biological Activity

Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.

Biochem/physiol Actions

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

References

[1] Patent: US4487773, 1984, A

Nefazodone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Nefazodone hydrochloride Suppliers

Americas 1 Belgium 1 Brazil 2 Canada 6 China 134 Europe 3 Germany 5 India 13 Israel 1 Japan 4 Singapore 1 South Korea 1 Spain 1 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 44 Global 231
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
EJY Tech, Inc.
Tel
--
Fax
--
Country
United States
ProdList
448
Advantage
30
Sarchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@sarchemlabs.com
Country
United States
ProdList
736
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Glixx Laboratories Inc.
Tel
--
Fax
--
Email
sales@glixxlabs.com
Country
United States
ProdList
30
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
MedKoo Biosciences, Inc.
Tel
--
Fax
--
Email
sales@medkoo.com
Country
United States
ProdList
126
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Cerilliant Corporation
Tel
--
Fax
--
Email
techserv@cerilliant.com
Country
United States
ProdList
1629
Advantage
69
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
SHAMROCK INDUSTRIAL CO. LTD.
Tel
--
Fax
--
Email
pharma@shamrockindia.com
Country
United States
ProdList
119
Advantage
43
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
CacheSyn Inc.
Tel
--
Fax
--
Email
info@cachesyn.com
Country
United States
ProdList
695
Advantage
50
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
SynFine Research
Tel
--
Fax
--
Email
research@synfine.com
Country
United States
ProdList
1024
Advantage
68
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
More
Less

View Lastest Price from Nefazodone hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Nefazodone hydrochloride 82752-99-6
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-26
Career Henan Chemical Co
Product
Nefazodone hydrochloride 82752-99-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

82752-99-6, Nefazodone hydrochlorideRelated Search:

Naphazoline hydrochloride Topotecan hydrochloride Furazolidone Naphazoline Triadimefon Trazodone Nefazodone Related Compound B,Nefazodone Related Compound B NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts),NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts) 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Nefazodone Related Compound A,Nefazodone Related Compound A HYDROXY NEFAZODONE HCL,HYDROXY NEFAZODONE HCL Nefazodone hydrochloride NEFAZODONE , TRAZODONE,NEFAZODONE , TRAZODONE HYDROXY NEFAZODONE-D5 HCL,HYDROXY NEFAZODONE-D5 HCL 5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazole-3-one (intermediate of nefazodone hcl) Nefazodone Hcl

  • NEFAZODONE-D5 HCL
  • 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
  • Nefazodone HCl
  • Nefazodone hydrochloride
  • NEFAZODONE
  • BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
  • 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
  • Nefazodone Hydrochloride (200 mg)
  • 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
  • BMY 13754-1
  • Serazone
  • Nefazodone hydrochloride API
  • 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride
  • Nefazodone hydrochlo
  • 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-
  • >=98% (HPLC)
  • 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4
  • 3-(4-Bromophenyl)-1H-pyrazole-5-carboxylic acid &ge
  • Boc-L-propraglycine dicyclohexylammonium salt &ge
  • Ethyl 2-amino-4-methylpyrimidine-5-carboxylate &ge
  • Indole-6-carboxaldehyde &ge
  • 4-Chloro-6,7-dimethoxyquinazoline &ge
  • 4-(4-Nitrophenoxy)benzaldehyde &ge
  • Formyl-L-methionine &ge
  • 5-Azacytosine &ge
  • 3-(4-Methylphenyl)-1H-pyrazole-4-carbaldehyde &ge
  • Fmoc-L-aspartic acid a-allyl ester &ge
  • 5-Amino-3-(4-bromophenyl)pyrazole &ge
  • 2-Amino-6-methyl-5-nitropyridine &ge
  • Boc-D-cyclopropylglycine &ge
  • 3-(4-Methylphenyl)-1H-pyrazole-5-carboxylic acid &ge
  • -diphosphate potassium salt &ge
  • 2-(4-Methoxyphenyl)succinic acid &ge
  • Z-L-pyroglutamic acid N-hydroxysuccinimide ester &ge
  • 5-(4-Nitrophenyl)-1H-tetrazole &ge
  • 5-(4-Fluorophenyl)-1,3,4-oxadiazole-2-thiol &ge
  • Boc-a-methyl-L-phenylalanine &ge
  • Pentafluoro-L-b-homophenylalanine hydrochloride &ge
  • Z-L-threonine methyl ester &ge
  • Na-Z-D-tryptophan &ge
  • Z-6-aminohexanoic acid &ge
  • 3-(4-Methoxyphenyl)-pyrazole-4-carboxylic acid &ge
  • (R,S)-Fmoc-2-amino-4,4,4-trifluoro-butyric acid &ge
  • Z-L-alanine-N-hydroxysuccinimide ester &ge
  • 6-Bromo-DL-tryptophan &ge
  • Fmoc-4-amino-L-phenylalanine &ge
  • 4-(4-Nitrophenoxy)Benzoic Acid &ge
  • Z-DL-proline &ge
  • O-Benzyl-L-serine methyl ester hydrochloride &ge
  • Methyl 2-Hydroxy-4-Morpholinobenzoate &ge
  • Boc-2-chloro-D-phenylalanine &ge
  • Boc-4,4-Difluoro-L-proline &ge
  • Ethyl 4-hydroxy-6-methylquinoline-3-carboxylate &ge
  • Na-Fmoc-Ng-Boc-D-2,4-diaminobutyric acid &ge
  • 4-(Bromomethyl)-3-(4-chlorophenyl)-5-methylisoxazole &ge
  • 4-Amino-2-chloro-5-nitropyridine &ge
  • 11-Tritylmercapto-undecanoic acid &ge
  • Fmoc-Ne-methyltrityl-D-lysine &ge