Aminophylline
Description References- Product Name
- Aminophylline
- CAS No.
- 317-34-0
- Chemical Name
- Aminophylline
- Synonyms
- aminophyllin;ethophylline;THEOPHYLLINE ETHYLENEDIAMINE;theomin;euufilin;grifomin;miofilin;theodrox;theolone;cardiomin
- CBNumber
- CB8145350
- Molecular Formula
- C9H16N6O2
- Formula Weight
- 240.27
- MOL File
- 317-34-0.mol
Aminophylline Property
- Melting point:
- 269-270 °C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O: 3.7 mg/mL solutions should be freshly prepared.
- form
- powder
- pka
- pKa 5.0 (Uncertain)
- color
- white to off-white
- Water Solubility
- soluble
- Merck
- 14,465
- InChI
- InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2
- InChIKey
- LHRHXWBJUQKYEL-UHFFFAOYSA-N
- SMILES
- O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN
- LogP
- -0.175 (est)
- CAS DataBase Reference
- 317-34-0(CAS DataBase Reference)
- EPA Substance Registry System
- 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0)
Safety
- Hazard Codes
- Xn,C
- Risk Statements
- 22-42/43-34-36/37/38-20/21/22
- Safety Statements
- 45-36/37/39-26-23-36
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- XH5600000
- F
- 10-23
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29339900
- Hazardous Substances Data
- 317-34-0(Hazardous Substances Data)
- Toxicity
- LD50 orally in mice: 540 mg/kg (Thompson, Warren)
N-Bromosuccinimide Price
- Product number
- A1755
- Product name
- Aminophylline
- Purity
- ≥98%, powder
- Packaging
- 25g
- Price
- $65.2
- Updated
- 2024/03/01
- Product number
- A1755
- Product name
- Aminophylline
- Purity
- ≥98%, powder
- Packaging
- 100g
- Price
- $115
- Updated
- 2024/03/01
- Product number
- J60705
- Product name
- Aminophylline, anhydrous, 98%
- Packaging
- 25g
- Price
- $31.65
- Updated
- 2024/03/01
- Product number
- J60705
- Product name
- Aminophylline, anhydrous, 98%
- Packaging
- 100g
- Price
- $98.3
- Updated
- 2024/03/01
- Product number
- 22235
- Product name
- Aminophylline
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $26
- Updated
- 2024/03/01
Aminophylline Chemical Properties,Usage,Production
Description
Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.
References
https://www.drugbank.ca/drugs/DB01223 https://en.wikipedia.org/wiki/Aminophylline
Description
Aminophylline is a 2/1 mixture of theophylline and ethylenediamine. It caused contact dermatitis in industrial plants, in pharmacists, and in nurses. Ethylenediamine is the sensitizer, and patch testing is generally positive to both ethylenediamine and aminophylline, but negative to theophylline.
Chemical Properties
white to slightly yellowish powder
Originator
Memcophylline,Memphis Co.
Uses
Bronchodilatator;Mastocytes degranulation inhibitor
Uses
Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
Uses
Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils. It is mostly used to prepare solutions for intravenous injections.
Definition
ChEBI: Aminophylline is a mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. It has a role as a bronchodilator agent and a cardiotonic drug. It contains a theophylline and an ethylenediamine.
Manufacturing Process
A mixture of 198 g (1 mol) theophylline and 60-78 g (0.75-1 mol) ethylenediamine hydrate in 300 g of water was stirred at 50°C and then the mixture was concentrated in vacuo. The product (aminophylline) was separeted by suction filtration. Aminophylline was used as an aqueous solution.
brand name
Phyllocontin (Purdue Frederick); Somophyllin (Fisons); Truphylline (G & W);Afonilum;Aminomal;Aminophylline injection;Aminophylline mudrane;Aminophylline oral;Amino-slow;Amnivent;Asmafilin;Cardophylline;Carine;Colonofilin;Corfilamine;Corophylline;Corphyllamin;Duraphyllin;Escophylline;Eudiamine;Euphyllin 0.48;Euphyllin retard;Euphylllin cr;Euphylllina;Fadfilina;Godafilin;Jaa aminophylline;Mini-lix;Mudrane gg;Mundiphyllin;Palaran;Palaron;Pecram;Pecran;Peterphylin;Phyllotemp;Planphylline;Somophyllin-12;Syntophyllin;Teophyllamin;Thodrox;Variaphylline.
Therapeutic Function
Diuretic, Cardiac stimulant, Smooth muscle relaxant, Vasodilator
World Health Organization (WHO)
Aminophylline, the ethylenediamine salt of theophylline, was introduced many years ago as a treatment for asthma and is listed in the 8th WHO Model List of Essential Drugs. It has been recognized for some 10 years that aminophylline preparations are not interchangeable because bioavailability can vary considerably. The resulting variability in drug absorption can lead to adverse effects including irritation of the mucosa. Allergic reation can also be an adverse effect of aminophylline. Theophylline functions similarly but is considered less of an irritant.
Hazard
Cardiovascular and respiratory collapse.
Contact allergens
This drug is a 2:1 mixture of the alkaloid theophylline and ethylenediamine (see below). It caused contact dermatitis in industrial plants, pharmacists, and nurses. Ethylenediamine is the sensitizer and patch testing is generally positive to both ethylenediamine and aminophylline and negative to theophylline.
Clinical Use
Reversible airways obstruction
Acute severe asthma
Veterinary Drugs and Treatments
The theophyllines are used primarily for their bronchodilatory effects, often in patients with myocardial failure and/or pulmonary edema. While they are still routinely used, the methylxanthines must be used cautiously due to their adverse effects and toxicity.
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: increased concentration with
azithromycin, clarithromycin, erythromycin,
ciprofloxacin, norfloxacin and isoniazid; decreased
erythromycin levels if erythromycin is given
orally; increased risk of convulsions if given with
quinolones; rifampicin accelerates metabolism of
aminophylline.
Antidepressants: concentration increased by
fluvoxamine - avoid or halve theophylline dose and
monitor levels; concentration reduced by St John’s
wort - avoid.
Antiepileptics: metabolism increased by
carbamazepine, phenobarbital and primidone;
concentration of both drugs increased with
fosphenytoin and phenytoin.
Antifungals: concentration increased by fluconazole
and ketoconazole.
Antivirals: metabolism of aminophylline increased
by ritonavir; concentration possibly increased by
aciclovir.
Calcium-channel blockers: concentration increased
by diltiazem and verapamil and possibly other
calcium-channel blockers.
Deferasirox: concentration of aminophylline
increased.
Feboxostat: use with caution.
Interferons: reduced metabolism of aminophylline.
Tacrolimus: may increase tacrolimus levels.
Ulcer-healing drugs: metabolism inhibited by
cimetidine; absorption possibly reduced by sucralfate.
Metabolism
Aminophylline is metabolised to theophylline in vivo. Theophylline is excreted in the urine as metabolites, mainly 1,3-dimethyluric acid and 3-methylxanthine, and about 10% is excreted unchanged.
Aminophylline Preparation Products And Raw materials
Raw materials
Preparation Products
Aminophylline Suppliers
- Tel
- 19103869591
- 1814581@qq.com
- Country
- China
- ProdList
- 204
- Advantage
- 58
- Tel
- 15937185894
- 1491216367@qq.com
- Country
- China
- ProdList
- 68
- Advantage
- 58
- Tel
- 18995688786 18995688786
- 156716255@qq.com
- Country
- China
- ProdList
- 260
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8835
- Advantage
- 52
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2862
- Advantage
- 58
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4940
- Advantage
- 60
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 0755-83725681-603
- Fax
- +86 755 28094224
- Country
- China
- ProdList
- 4496
- Advantage
- 50
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4674
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 1672
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18070
- Advantage
- 56
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7787
- Advantage
- 56
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 400-6087598 15021221957
- Fax
- 4006087598-8012
- order@canspecsci.com
- Country
- China
- ProdList
- 2045
- Advantage
- 56
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4943
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 16166
- Advantage
- 55
- Tel
- 027-59420981,18702770802
- Fax
- 027-83322098
- Country
- China
- ProdList
- 1975
- Advantage
- 50
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 13391076197
- tombiopharma@163.com
- Country
- China
- ProdList
- 4987
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 027-59207879 1972026995 18140587686
- Fax
- QQ：1972026995
- sales@3600chem.com
- Country
- China
- ProdList
- 4658
- Advantage
- 55
- Tel
- 0570-8789886 18892685668
- Fax
- 0570-8789985
- info@rundongchemical.com
- Country
- China
- ProdList
- 3970
- Advantage
- 60
- Tel
- +86 (27) 8778653
- Fax
- +86 (27) 8773-8652
- 13720228325@163.com
- Country
- China
- ProdList
- 337
- Advantage
- 58
- Tel
- 4000-819-385 010-62329685 13718666987
- Fax
- 010-62340519
- Country
- China
- ProdList
- 1971
- Advantage
- 55
- Tel
- 028-88469284 18000562381
- rzbtsj@163.com
- Country
- China
- ProdList
- 9951
- Advantage
- 56
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 17687
- Advantage
- 55
- Tel
- 0571-87157530-8007 13868066926
- Fax
- 0571-87156470
- sales@dingyanchem.com
- Country
- China
- ProdList
- 2190
- Advantage
- 58
- Tel
- 18936048580
- chemxilang@163.com
- Country
- China
- ProdList
- 4008
- Advantage
- 58
View Lastest Price from Aminophylline manufacturers
- Product
- Aminophylline 317-34-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 84.0-87.4%,BP2015,USP38
- Supply Ability
- 800kg/month
- Release date
- 2021-06-18
- Product
- Aminophylline 317-34-0
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-12-13
- Product
- Aminophylline 317-34-0
- Price
- US $500.00-300.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-23