2-Chloro-5-methylpyridine-3-carboxylic acid
- Product Name
- 2-Chloro-5-methylpyridine-3-carboxylic acid
- CAS No.
- 66909-30-6
- Chemical Name
- 2-Chloro-5-methylpyridine-3-carboxylic acid
- Synonyms
- 2-Chloro-5-Methylnicotinic Acid(WX614044);2-Chloro-5-methylpyridin-3-carboxylic acid;2-chloro-5-methyl-3-Pyridinecarboxylic acid;2-Chloro-5-methylpyridine-3-carboxylic acid;2-Chloro-5-methylpyridin-3-ylcarboxylic acid;3-Pyridinecarboxylic acid, 2-chloro-5-methyl-
- CBNumber
- CB81471126
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 66909-30-6.mol
2-Chloro-5-methylpyridine-3-carboxylic acid Property
- Melting point:
- 199 °C
- Boiling point:
- 331.2±37.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.10±0.25(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000743
- Product name
- 2-Chloro-5-methylnicotinic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- C384723
- Product name
- 2-Chloro-5-methylnicotinic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C384723
- Product name
- 2-Chloro-5-methylnicotinic acid
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 054072
- Product name
- 2-Chloro-5-methylnicotinic acid
- Packaging
- 500mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- FC139983
- Product name
- 2-Chloro-5-methylnicotinic acid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
2-Chloro-5-methylpyridine-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
65169-43-9
66909-30-6
General procedure for the synthesis of 2-chloro-5-methylnicotinic acid from 2-chloro-5-methylnicotinic acid methyl ester: Intermediate 31 (2-chloro-5-methylnicotinic acid methyl ester, 0.38 g, 1.81 mmol) was dissolved in methanol (2 ml) and 2N sodium hydroxide solution (1.81 ml, 3.62 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was redissolved in ethyl acetate/water. The organic layer was separated, dried over magnesium sulfate and subsequently concentrated in vacuum to afford the target product 2-chloro-5-methylnicotinic acid as a white solid in 94% yield.LRMS: m/z 172 (M + 1)+; retention time: 3.25 min.1H NMR (200 MHz, DMSO-D6) δppm: 2.2 (s, 3H); 7.6 (d, J = 2.53 Hz , 1H); 8.0 (d, J = 2.53 Hz, 1H).
References
[1] Patent: WO2008/77639, 2008, A1. Location in patent: Page/Page column 26-27
2-Chloro-5-methylpyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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