ChemicalBook > CAS DataBase List > 2-Chloro-5-methylpyridine-3-carboxylic acid

2-Chloro-5-methylpyridine-3-carboxylic acid

Product Name: 2-Chloro-5-methylpyridine-3-carboxylic acid
CAS No.: 66909-30-6
Chemical Name: 2-Chloro-5-methylpyridine-3-carboxylic acid
Synonyms: 2-Chloro-5-Methylnicotinic Acid(WX614044);2-Chloro-5-methylpyridin-3-carboxylic acid;2-chloro-5-methyl-3-Pyridinecarboxylic acid;2-Chloro-5-methylpyridine-3-carboxylic acid;2-Chloro-5-methylpyridin-3-ylcarboxylic acid;3-Pyridinecarboxylic acid, 2-chloro-5-methyl-
CBNumber: CB81471126
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 66909-30-6.mol

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2-Chloro-5-methylpyridine-3-carboxylic acid Property

Melting point:: 199 °C
Boiling point:: 331.2±37.0 °C(Predicted)
Density: 1.390±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.10±0.25(Predicted)
form: solid
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000743
Product name: 2-Chloro-5-methylnicotinic acid
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

TRC

Product number: C384723
Product name: 2-Chloro-5-methylnicotinic acid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C384723
Product name: 2-Chloro-5-methylnicotinic acid
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139983
Product name: 2-Chloro-5-methylnicotinic acid
Packaging: 500mg
Price: $115
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139983
Product name: 2-Chloro-5-methylnicotinic acid
Packaging: 1g
Price: $180
Updated: 2021/12/16

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2-Chloro-5-methylpyridine-3-carboxylic acid Chemical Properties,Usage,Production

Synthesis

65169-43-9

66909-30-6

General procedure for the synthesis of 2-chloro-5-methylnicotinic acid from 2-chloro-5-methylnicotinic acid methyl ester: Intermediate 31 (2-chloro-5-methylnicotinic acid methyl ester, 0.38 g, 1.81 mmol) was dissolved in methanol (2 ml) and 2N sodium hydroxide solution (1.81 ml, 3.62 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was redissolved in ethyl acetate/water. The organic layer was separated, dried over magnesium sulfate and subsequently concentrated in vacuum to afford the target product 2-chloro-5-methylnicotinic acid as a white solid in 94% yield.LRMS: m/z 172 (M + 1)+; retention time: 3.25 min.1H NMR (200 MHz, DMSO-D6) δppm: 2.2 (s, 3H); 7.6 (d, J = 2.53 Hz , 1H); 8.0 (d, J = 2.53 Hz, 1H).

References

[1] Patent: WO2008/77639, 2008, A1. Location in patent: Page/Page column 26-27

2-Chloro-5-methylpyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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