ChemicalBook > CAS DataBase List > 2,3-Dichlorobenzoyl cyanide

2,3-Dichlorobenzoyl cyanide

Product Name
2,3-Dichlorobenzoyl cyanide
CAS No.
77668-42-9
Chemical Name
2,3-Dichlorobenzoyl cyanide
Synonyms
2,3-Dichlorobenzoylc;Lamotrigine Impurity 5;Lamotrigine Impurity 10;Lamotrigine Impurity 25;2,3-DichloroBenzoylNitrile;2,3-dichlorobenozyl cyanide;2,3-DICHLOROBENZOYL CYANIDE;Dichlorobenzoyl Lamotrigine;2,3-Dichlorobenzoyl cyanide, 98%;(2,3-dichlorophenyl)oxoacetonitrile
CBNumber
CB8147167
Molecular Formula
C8H3Cl2NO
Formula Weight
200.02
MOL File
77668-42-9.mol
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2,3-Dichlorobenzoyl cyanide Property

Melting point:
52-53 °C(Solv: ligroine (8032-32-4))
Boiling point:
309°C
Density 
1.446
Flash point:
141°C
storage temp. 
Sealed in dry,Room Temperature
form 
solid
color 
Cream
InChI
InChI=1S/C8H3Cl2NO/c9-6-3-1-2-5(8(6)10)7(12)4-11/h1-3H
InChIKey
FIBBFBXFASKAON-UHFFFAOYSA-N
SMILES
C1(C(=O)C#N)=CC=CC(Cl)=C1Cl
CAS DataBase Reference
77668-42-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
RIDADR 
UN3439
Hazard Note 
Irritant
HazardClass 
6.1
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D432250
Product name
2,3-DichlorobenzoylNitrile
Packaging
50g
Price
$1185
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
56831
Product name
2,3-DichlorobenzoylNitrile
Packaging
100g
Price
$2450
Updated
2021/12/16
Matrix Scientific
Product number
084725
Product name
2,3-Dichlorobenzoyl cyanide
Purity
97%
Packaging
500g
Price
$405
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD33387
Product name
2,3-Dichlorobenzoyl cyanide
Packaging
100g
Price
$480
Updated
2021/12/16
AK Scientific
Product number
J50793
Product name
2,3-Dichlorobenzoylcyanide
Packaging
1g
Price
$10
Updated
2021/12/16
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2,3-Dichlorobenzoyl cyanide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2,3-Dichlorobenzoyl cyanide is an impurity of Lamotrigine (L173250), an anticonvulsant that is used in the treatment of bipolar and depression.

Synthesis

2905-60-4

143-33-9

77668-42-9

1. Synthesis of 2,3-dichlorobenzoyl cyanide 2,3-Dichlorobenzoyl chloride (20.0 g, 100 mmol) and cuprous iodide (I) (0.90 g, 4.7 mmol) were suspended in acetonitrile (50 mL) and stirred at room temperature until a yellow homogeneous solution was formed. Solid sodium cyanide (5.15 g, 110 mmol) was added slowly with a controlled addition time of 5-8 hours. After addition, stirring of the reaction mixture was continued for 1 h. The reaction progress was monitored by HPLC. The resulting inorganic salt (mainly NaCl) was removed by filtration and the filter cake was washed with acetonitrile (15 mL). Acetonitrile was removed by distillation under reduced pressure (~150 mbar). Sodium metabisulfite (Na2S2O3, 0-4 g, 3 mmol) was added to remove trace iodine. Finally, the product was purified by vacuum distillation (jacket temperature 140°C, boiling point 115°C/2 mbar) to give 2,3-dichlorobenzoyl cyanide in >80% yield and 100% purity (as determined by analytical HPLC) with a melting point of 60°C.

References

[1] Patent: WO2008/19798, 2008, A1. Location in patent: Page/Page column 12

2,3-Dichlorobenzoyl cyanide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,3-Dichlorobenzoyl cyanide manufacturers

RongNa Biotechnology Co.,Ltd
Product
2,3-Dichlorobenzoyl cyanide 77668-42-9
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
1 ton
Release date
2025-08-22
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,3-Dichlorobenzoyl cyanide 77668-42-9
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-25
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
2,3-Dichlorobenzoyl cyanide 77668-42-9
Price
US $980.00-750.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-15

77668-42-9, 2,3-Dichlorobenzoyl cyanide Related Search:

2-Chlorobenzoyl chloride Benzoyl cyanide 2,4-Dichlorobenzyl chloride 2,3-Dichlorobenzoic acid (Z)-[cyano(2,3-dichlorophenyl)methylene]carbazamidine 3-Dechloro-4-chloro Lamotrigine 1,3-Dichlorobenzene Lamotrigine LaMotrigine IMpurity D Lamotrigine N2-Oxide 2,4-Dichlorobenzoyl Cyanide Lamotrigine Impurity 3 Lamotrigine N2-Glucuronide (E)-3-[cyano(2,3-dichlorophenyl)methylene]carbazamidine Dibenzoylmethane LaMotrigine Related CoMpound C Lamotrigine Impurity 6 Lamotrigine Impurity 4

  • 2-(2,3-Dichlorophenyl)-2-oxoacetonitrile
  • 2,3-DICHLOROBENZOYL CYANIDE
  • (2,3-dichlorophenyl)oxoacetonitrile
  • 2,3-DichloroBenzoylNitrile
  • 2,3-dichlorobenozyl cyanide
  • 2,3-Dichloro-α-oxobenzeneacetonitrile
  • 2,3-Dichlorobenzoylc
  • 2-(2,3-Dichlorophenyl)-2-oxoacetonitrile (2,3-Dichlorobenzoyl Nitrile)
  • Lamotrigine Impurity 10
  • Lamotrigine Impurity 5
  • 2,3 - Dichloro benzoyl nitrile (LMG 1 )
  • Lamotrigine (2,3 Dichlorophenyl)-oxoacetonitrile
  • Benzeneacetonitrile, 2,3-dichloro-α-oxo-
  • Lamotrigine Impurity 25
  • 2,3-Dichloro benzolyl nitrileQ: What is 2,3-Dichloro benzolyl nitrile Q: What is the CAS Number of 2,3-Dichloro benzolyl nitrile Q: What is the storage condition of 2,3-Dichloro benzolyl nitrile Q: What are the applications of 2,3-Dichloro benzolyl nitrile
  • 2-(2,3-Dichlorophenyl)-2-oxoacetonitrile (2,3-Dichlorobenzoylcyanide)
  • Dichlorobenzoyl Lamotrigine
  • 2,3-Dichloro Benzoyl Cyanide [Side Chain]
  • 2,3-Dichlorobenzoyl cyanide, 98%
  • 77668-42-9
  • 77668-45-9
  • C8H3Cl2NO
  • Nitriles
  • Lamotrigine