3-Amino-5-cyclobutyl-1H-pyrazole
- Product Name
- 3-Amino-5-cyclobutyl-1H-pyrazole
- CAS No.
- 326827-21-8
- Chemical Name
- 3-Amino-5-cyclobutyl-1H-pyrazole
- Synonyms
- 5-Amino-3-cyclobutylpyrazole;3-AMino-5-cyclobutyl-1H-p...;5-Cyclobutyl-1H-pyrazol-3-aMine;3-AMino-5-cyclobutyl-2H-pyrazole;3-Amino-5-cyclobutyl-1H-pyrazole;1H-Pyrazol-3-amine, 5-cyclobutyl-
- CBNumber
- CB81475997
- Molecular Formula
- C7H11N3
- Formula Weight
- 137.18
- MOL File
- 326827-21-8.mol
3-Amino-5-cyclobutyl-1H-pyrazole Property
- Boiling point:
- 368.1±30.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 15.68±0.10(Predicted)
- Appearance
- White to light yellow Solid-liquid mixture
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Air Sensitive
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A578168
- Product name
- 3-Amino-5-cyclobutyl-1H-pyrazole
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 3H32-1-C1
- Product name
- 3-Amino-5-cyclobutyl-1H-pyrazole
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 3H32-1-C1
- Product name
- 3-Amino-5-cyclobutyl-1H-pyrazole
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3669AB
- Product name
- 3-Amino-5-cyclobutyl-1H-pyrazole
- Packaging
- 1g
- Price
- $238
- Updated
- 2021/12/16
- Product number
- 057832
- Product name
- 3-Cyclobutyl-1H-pyrazol-5-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
3-Amino-5-cyclobutyl-1H-pyrazole Chemical Properties,Usage,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
118431-89-3
326827-21-8
General procedure for the synthesis of 3-amino-5-cyclobutyl-1H-pyrazole from 3-cyclobutyl-3-oxopropanenitrile: Crude 3-cyclobutyl-3-oxopropanenitrile (10.0 g, 81.3 mmol) was dissolved in ethanol (300 mL), followed by addition of hydrazine in equimolar amounts. The reaction mixture was heated to 75 °C in an oil bath for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated oily product was dissolved in ethyl acetate and washed with saturated aqueous sodium bicarbonate. After separating the organic and aqueous layers, the aqueous layer was then extracted with ethyl acetate. All organic layers were combined, dried with anhydrous magnesium sulfate, filtered to remove the desiccant and the filtrate was concentrated under reduced pressure. The crude product was purified by rapid column chromatography on a Biotage 75S MPLC system (Dynax Corp., Charlottesville, VA), eluting sequentially with pure ethyl acetate (2 L) and 10% methanol/dichloromethane (2 L). The fraction containing the target product was collected and concentrated under reduced pressure to afford 3-amino-5-cyclobutyl-1H-pyrazole (10.0 g, 91% yield) as a brown oil. Its structure was confirmed by 400 MHz 1H NMR (CDCl3) and LRMS (APCI+): 1H NMR δ 5.47 (s, 1H), 5.25 (bs, 3H), 3.40 (dddd, J = 8.3,8.3,8.3,8.3, 8.3Hz, 1H), 2.34-2.27 (m, 2H), 2.16-1.88 (m. 4H); LRMS m/z (APCI+) 138 (M + 1).
References
[1] Patent: US2004/266815, 2004, A1. Location in patent: Page 11-12
[2] Bioorganic and Medicinal Chemistry Letters, 2018,
3-Amino-5-cyclobutyl-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-5-cyclobutyl-1H-pyrazole manufacturers
- Product
- 3-Amino-5-cyclobutyl-1H-pyrazole 326827-21-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12