1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Product Name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- CAS No.
- 67085-11-4
- Chemical Name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Synonyms
- BUTOCOZOL IMPURITY 2;Butoconazol Impurity 2;Butoconazole Impurity 2;Butoconazole Nitrate INT II;Butoconazole 2-Hydroxy Impurity;1-[4-(4-Chlorophenyl)-2-hydroxylbutyl];4-(4-chlorophenyl)-1-imidazol-1-ylbutan-2-ol;4-(4-Chlorophenyl)-1-(1-imidazolyl)-2-butanol;1-[4-(4-CHLOROPHENYL)-2-HYDROXYLBUTYL]IMIDAZOLE;4-(4-Chlorophenyl)-1-(1H-iMidazol-1-yl)butan-2-ol
- CBNumber
- CB81476378
- Molecular Formula
- C13H15ClN2O
- Formula Weight
- 250.72
- MOL File
- 67085-11-4.mol
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Property
- Melting point:
- 106-109 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 472.2±40.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO, Methanol (Slightly)
- form
- Solid
- pka
- 13.69±0.20(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C378070
- Product name
- α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol
- Packaging
- 5g
- Price
- $670
- Updated
- 2021/12/16
- Product number
- C378070
- Product name
- α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol
- Packaging
- 10g
- Price
- $1030
- Updated
- 2021/12/16
- Product number
- FC150299
- Product name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Packaging
- 50mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FC150299
- Product name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Packaging
- 250mg
- Price
- $192.5
- Updated
- 2021/12/16
- Product number
- FC150299
- Product name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Packaging
- 500mg
- Price
- $335
- Updated
- 2021/12/16
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Chemical Properties,Usage,Production
Uses
α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is used as a reactant in the preparation of imidazol phenylbutane derivatives as heme oxygenase inhibitors. α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is also an impurity of Butoconazole (B690273), which is an antifungal.
Synthesis
288-32-4
59363-13-2
67085-11-4
(2) In a dry DMF solvent, sodium hydride (in the form of mineral oil dispersion) at a concentration of 20% was added and 20 mL of a DMF solution of imidazole was added dropwise at a rate of 2 mL/s under ice bath cooling conditions. Subsequently, the reaction mixture was stirred at 60 °C for 60 min. After the ice bath was cooled, Intermediate 1 (weight ratio of imidazole, sodium hydride to Intermediate 1 was 7:7:5) was slowly added via the salt bath method. The reaction mixture was continued to be stirred at 60°C for 120 minutes. After completion of the reaction, the reaction was again cooled in an ice bath and a 25% n-hexane solution was added to the reaction mixture and stirred at a rate of 3 rev/s for 15 min. Subsequently, ice (350% by weight of the reaction mixture) was added and stirring was continued at a rate of 3 rev/s until the precipitation was complete. The precipitate was collected by filtration and the filter cake was washed once with water and then dried by centrifugation at 2830 r/min for 60 minutes. The resulting product was treated with 2.5 times its weight of ethyl acetate and 0.05 times its weight of activated charcoal, left to stand at 5 °C for 13 h, followed by recrystallization at 50 °C. The yield of Intermediate 2 was 71.5% by HPLC analysis, wherein the purity of the target product 1-[4-(4-chlorophenyl)-2-hydroxy-n-butyl]imidazole was 99.31%.
References
[1] Patent: CN105218455, 2016, A. Location in patent: Paragraph 0055
[2] Patent: CN105175341, 2017, B. Location in patent: Paragraph 0048-0052
[3] Patent: CN105175338, 2018, B. Location in patent: Paragraph 0069-0071
[4] Patent: CN107501190, 2017, A. Location in patent: Paragraph 0033; 0036; 0043; 0046
[5] Patent: WO2005/70897, 2005, A1. Location in patent: Page/Page column 7
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Suppliers
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View Lastest Price from 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole manufacturers
- Product
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole 67085-11-4
- Price
- US $0.99/KG
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2021-12-09
- Product
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole 67085-11-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-29