ZOSUQUIDAR TRIHYSROCHLORIDE

Product Name: ZOSUQUIDAR TRIHYSROCHLORIDE
CAS No.: 167465-36-3
Chemical Name: ZOSUQUIDAR TRIHYSROCHLORIDE
Synonyms: LY335979;Trihydrochloride;CS-58;D06387;RS 33295-198;LY335979) 3HCl;Zosuquidar HCl;Zosuquidr.3HCl;Zosuquidar 3HCl;Zosuquidar TriHCl
CBNumber: CB81482979
Molecular Formula: C32H32ClF2N3O2
Formula Weight: 564.07
MOL File: 167465-36-3.mol

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ZOSUQUIDAR TRIHYSROCHLORIDE Property

Melting point:: 172-176°C
storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Slightly), Water (Slightly, Sonicated)
form: Solid
color: Pale Yellow to Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21533
Product name: Zosuquidar (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21533
Product name: Zosuquidar (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 21533
Product name: Zosuquidar (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 21533
Product name: Zosuquidar (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Tocris

Product number: 5456
Product name: Zosuquidartrihydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $844
Updated: 2021/12/16

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ZOSUQUIDAR TRIHYSROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).

Biological Activity

ly335979 is a selective inhibitor of p-gp with ic50 value of 1.2 nm [1, 2].p-gp (p-glycoprotein) is a member of atp-binding cassette (abc) transporters and plays a pivotal role in pumping many foreign substances out of cells. it has been reported that abnormal expression of p-gp is correlated with the multidrug resistance of tumor cells [3].ly335979 is a potent p-gp inhibitor and has a different selectivity with the reported p-gp inhibitor cyclosporin a or verapamil. in drug-resistant cell line hl60/vcr with highly expression of p-gp, ly335979 exhibited highly restore ability of p-gp than cyclosporin a or verapamil and the ic 50 value of 1.2 nm [1]. when tested with a panel of cell lines over-expressed p-gp (cem/vlb100, mcf-7/adr, 2780ad, p388/adr, and ucla-p3.003vlb), administration of ly335979 reversed the cells resistance to vinblastine, doxorubicin, btoposide and taxol by inhibiting p-gp activity [2].in female nude mice model with ucla-p3.003vlb mdr tumor cells subcutaneous xenograft, pre-treated with ly335979 (30mg/kg) restored tumor cells sensitivity to taxol (20 mg/kg) which combination markedly suppressed solid tumor growth compared with control group [2].

storage

Store at -20°C

References

1. green, l.j., p. marder, and c.a. slapak, modulation by ly335979 of p-glycoprotein function in multidrug-resistant cell lines and human natural killer cells. biochem pharmacol, 2001. 61(11): p. 1393-9.2. dantzig, a.h., et al., reversal of p-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, ly335979. cancer res, 1996. 56(18): p. 4171-9.3. hu, t., et al., reversal of p-glycoprotein (p-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of salvia miltiorrhiza. phytomedicine, 2014. 21(11): p. 1264-72.

ZOSUQUIDAR TRIHYSROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ZOSUQUIDAR TRIHYSROCHLORIDE Suppliers

Canada 1 China 113 India 5 United Kingdom 2 United States 20 Global 141

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View Lastest Price from ZOSUQUIDAR TRIHYSROCHLORIDE manufacturers

Career Henan Chemical Co

Product: ZOSUQUIDAR TRIHYSROCHLORIDE 167465-36-3
Price: US $0.50/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 10g,100g,1kg
Release date: 2020-01-09

167465-36-3, ZOSUQUIDAR TRIHYSROCHLORIDERelated Search:

Zaltidine Zoledronic acid hydrate NU7441 (KU-57788) JNK-IN-8 Gefitinib Tariquidar SB 431542 Ibrutinib LY 2157299 LY 294002 HYDROCHLORIDE LY2811376 LY-2608204 LY 2874455 LY2090314 LY411575 LY-364947 LY2409881 trihydrochloride LY-2584702 (tosylate salt)

Zosuquidar 3HCl

Zosuquidar trihydrochloride, >=98%

Trihydrochloride

Zosuquidar (LY335979) triHydrochloride

D06387

LY 335979; LY-335979; LY335979; D06387; RS33295198;

(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

RS-33295-198; ZOSUQUIDAR; LY-335979

CS-58

LY335979

RS 33295-198

LY335979 (Zosuquidar 3HCl)

ZOSUQUIDAR TRIHYSROCHLORIDE

LY335979, RS 33295-198

Zosuquidar Trihydrochloride

[6(R)-(1aα,6α,10bα)]-4-(1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl)-α-[(5-quinolinyloxy)Methyl]-piperazineethanol trihydrochloride, (2R)-anti-5-{3-[4-(10,11-difluoroMethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy

RS-33295-198, ZOSUQUIDAR

(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)Methyl]-1-piperazineethanol Hydrochloride

LY335979 (Zosuquidar trihydrochloride)

(2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride

Zosuquidar (LY335979

1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-,trihydrochloride

RS 33295-198 (D06387) 3HCl

(2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride Zosuquidar trihydrochloride LY335979

Zosuquidar trihydrochloride LY335979

Zosuquidr.3HCl(LY335979)

Zosuquidar (LY335979) 3HCl

LY-335979 trihydrochloride

RS 33295-198 trihydrochloride

Zosuquidar TriHCl

ZOSUQUIDAR TRIHYSROCHLORIDE USP/EP/BP

1-Piperazineethanol,4-[(1aa,6a,10ba)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-a-[(5-quinolinyloxy)methyl]-,hydrochloride (1:3), (aR)-

LY335979) 3HCl

Zosuquidar (RS 33295-198

Zosuquidar HCl

Zosuquidr.3HCl

(R)-1-(4-((1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride

Zosuquidar trihydrochloride 3HCL

CEM/VLB100,Pgp,2780AD,Multidrug resistance protein 1,CD243,anti-tumor activity,P388/ADR,P-glycoprotein,UCLA-P3.003VLB,2780,ABCB1,MCF7,acute myelogenous leukemia,MDR1,HL60,P-gp,UCLA-P3,P388,MCF7/ADR,CCRF-CEM,K562,Inhibitor,Zosuquidar trihydrochloride,Cluster of differentiation 243,AML,inhibit

LY335979(Zosuquidar)/Zosuquidar trihydrochloride, RS-33295-198

4-piperazin-1-ylpyrrolidin-2-one

1-(3-aminocyclopentyl)-N,N-dimethyl-pyrrolidin-3-amine

Levodropropizine Impurity 12

N'-(3-pyridylmethyl)butane-1,4-diamine

methyl (4R)-4-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-[4-(3-pyridylmethylamino)butylamino]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate

167465-36-3

C32H31F2N3O23HCl

C32H34Cl3F2N3O2

C32H31F2N3O23ClH

Inhibitors

Aromatics

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals