ChemicalBook > CAS DataBase List > JNK-IN-8

JNK-IN-8

Product Name
JNK-IN-8
CAS No.
1410880-22-6
Chemical Name
JNK-IN-8
Synonyms
CS-1339;JNK-IN-8;JNK inhibitor 8;JNK Inhibitor XVI;JNK-IN-8 USP/EP/BP;JNK-IN-8 Only for R&D;JNK-IN-8 >=96% (HPLC);JNK-IN-8 JNK Inhibitor XVI;3-(4-(Dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;(E)-3-(4-(diMethylaMino)but-2-enaMido)-N-(3-Methyl-4-(4-(pyridin-3-yl)pyriMidin-2-ylaMino)phenyl)benzaMide
CBNumber
CB82624190
Molecular Formula
C29H29N7O2
Formula Weight
507.59
MOL File
1410880-22-6.mol
More
Less

JNK-IN-8 Property

Density 
1.283±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≥25.4 mg/mL in DMSO; insoluble in H2O; ≥9.24 mg/mL in EtOH with gentle warming and ultrasonic
form 
powder
pka
13.34±0.70(Predicted)
color 
white to beige
More
Less

Safety

HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1246
Product name
JNK-IN-8
Purity
≥96% (HPLC)
Packaging
5MG
Price
$185
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1246
Product name
JNK-IN-8
Purity
≥96% (HPLC)
Packaging
25MG
Price
$704
Updated
2023/06/20
Cayman Chemical
Product number
18096
Product name
JNK Inhibitor XVI
Purity
≥95%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
18096
Product name
JNK Inhibitor XVI
Purity
≥95%
Packaging
5mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
18096
Product name
JNK Inhibitor XVI
Purity
≥95%
Packaging
10mg
Price
$274
Updated
2024/03/01
More
Less

JNK-IN-8 Chemical Properties,Usage,Production

Uses

JNK-IN-8 has been used as an inhibitor to address the importance of JNK signaling in withaferin A (WFA)-induced apoptosis of myelodysplastic syndromes (MDS)-L cells.

Definition

ChEBI: 3-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide is a member of benzamides.

Biological Activity

jnk-in-8 is a specific jnk1/2/3 inhibitor with ic50 value of 4.67, 18.7, 0.98 nm respectively [1].c-jun n-terminal kinase (jnk) 1, 2 and 3 belong to the mitogen-activated protein kinase (mapk) family, which are able to phosphorylate c-jun on the ser63 and ser73 residue.they are responsive for stress stimuli, including cytokines and heat shock, and get involved in t cell differentiation and cell apoptosis process. jnk 1 and 2 are ubiquitous in all cell types but jnk 3 is only found in cells of brain, heart and testes tissues.jnk-in-8 is a jnk1/2/3 inhibitor with high specificity. when jnk-in-8 was profiled with a panel of 400 kinases, it exhibited specific binding to jnk 1/2/3 but not to other kinases. crystallization study also found that jnk-in-8 forms covalent bonds with conserved cysteine residue of jnk 1/2/3, resulting in a conformational change of the activation loop that blocks the substrate binding, thereby inhibiting the activity of jnk 1/2/3 [1].in hela cells and a375 cells, pretreatment of cells with jnk-in-8 resulted in the inhibition of c-jun which is a direct phosphorylation substrate of jnk 1/2/3, confirming the inhibitory action of jnk-in-8 on jnk 1/2/3. in hek293-ilr1 cells following stimulation by anisomycin, the jnk-in-8 was observed to inhibit c-jun but not msk1 and p38, and the inhibition was not reversible by removing jnk-in-8 from culture medium. additionally, jnk-in-8 only exhibited on-pathway inhibition of jnk signaling pathway, which can be monitored by the phosphorylation of c-jun [1].

Biochem/physiol Actions

JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3 that inhibits phosphorylation of c-Jun. JNK-IN-8 forms covalent bonds with a conserved cysteine residue.

target

JNK1

References

[1]. zhang t et al., discovery of potent and selective covalent inhibitors of jnk. chemical biology. 2012, 19(1):140-154.

JNK-IN-8 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

JNK-IN-8 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2782
Advantage
60
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
More
Less

View Lastest Price from JNK-IN-8 manufacturers

Career Henan Chemical Co
Product
JNK-IN-8 1410880-22-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
kg/T
Release date
2019-12-18

1410880-22-6, JNK-IN-8Related Search:


  • JNK-IN-8
  • (E)-3-(4-(diMethylaMino)but-2-enaMido)-N-(3-Methyl-4-(4-(pyridin-3-yl)pyriMidin-2-ylaMino)phenyl)benzaMide
  • 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
  • JNK Inhibitor XVI
  • Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
  • 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide JNK-IN-8
  • CS-1339
  • JNK inhibitor 8
  • JNK-IN-8 >=96% (HPLC)
  • JNK-IN-8 USP/EP/BP
  • JNK-IN-8 Only for R&D
  • 3-(4-(Dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
  • JNK-IN-8 JNK Inhibitor XVI
  • 1410880-22-6
  • C29H29N7O2
  • Inhibitors
  • MAPK
  • JNK-IN-8