N-(6-Bromopyridin-2-yl)acetamide

Product Name: N-(6-Bromopyridin-2-yl)acetamide
CAS No.: 25218-99-9
Chemical Name: N-(6-Bromopyridin-2-yl)acetamide
Synonyms: SKL879;N-(6-Bromopyridin-2-yl);2-Acetamido-6-bromopyridine;N-(6-Bromopyridin-2-yl)acetamide;AcetaMide,N-(6-broMo-2-pyridinyl)-
CBNumber: CB81501669
Molecular Formula: C7H7BrN2O
Formula Weight: 215.05
MOL File: 25218-99-9.mol

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N-(6-Bromopyridin-2-yl)acetamide Property

Melting point:: 157.4 °C
Boiling point:: 389.6±27.0 °C(Predicted)
Density: 1.630±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.15±0.70(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: A143800
Product name: 2-Acetamido-6-bromopyridine
Packaging: 10g
Price: $370
Updated: 2021/12/16

Usbiological

Product number: 414819
Product name: 2-Acetamido-6-bromopyridine
Packaging: 1g
Price: $319
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA146278
Product name: 2-Acetamido-6-bromopyridine
Packaging: 5G
Price: $410
Updated: 2021/12/16

AK Scientific

Product number: V4683
Product name: 2-Acetamido-6-bromopyridine
Packaging: 10g
Price: $477
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA146278
Product name: 2-Acetamido-6-bromopyridine
Packaging: 250mg
Price: $52.5
Updated: 2021/12/16

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N-(6-Bromopyridin-2-yl)acetamide Chemical Properties,Usage,Production

Uses

2-Acetamido-6-bromopyridine is a chemical reagent used in the synthesis of diarylureas used as allosteric modulators. Also used in the prouction of novel Bcl-Abl inhibitors with flexible linkers.

Synthesis

19798-81-3

75-36-5

25218-99-9

I. General procedure for the synthesis of N-(6-bromopyridin-2-yl)acetamide: Step a: To a solution of 6-bromopyridin-2-amine (10 g, 0.060 mol) and triethylamine (Et3N, 25 g, 0.27 mol) in dichloromethane (CH2Cl2, 300 mL) was slowly added acetyl chloride (AcCl, 13 g, 0.17 mol) at 0°C. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (EtOAc, 200 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to afford N-(6-bromopyridin-2-yl)acetamide (88% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.15 (d, J = 8.0 Hz, 1H), 7.97 (brs, 1H), 7.55 (t, J = 8.0 Hz, 1H), 7.18 (d, J = 8.0 Hz, 1H), 2.19 (s, 3H).

References

[1] Patent: WO2012/119979, 2012, A1. Location in patent: Page/Page column 34-35
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 15, p. 4730 - 4743
[3] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 84
[4] Patent: US2004/92741, 2004, A1. Location in patent: Page 4
[5] Patent: US2009/176842, 2009, A1. Location in patent: Page/Page column 13

N-(6-Bromopyridin-2-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(6-Bromopyridin-2-yl)acetamide Suppliers

China 42 India 1 United Kingdom 2 United States 5 Global 50

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25218-99-9, N-(6-Bromopyridin-2-yl)acetamideRelated Search:

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N-(6-Bromopyridin-2-yl)

N-(6-Bromopyridin-2-yl)acetamide

2-Acetamido-6-bromopyridine

AcetaMide,N-(6-broMo-2-pyridinyl)-

SKL879

25218-99-9

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