N-(6-Bromopyridin-2-yl)acetamide
- Product Name
- N-(6-Bromopyridin-2-yl)acetamide
- CAS No.
- 25218-99-9
- Chemical Name
- N-(6-Bromopyridin-2-yl)acetamide
- Synonyms
- SKL879;N-(6-Bromopyridin-2-yl);2-Acetamido-6-bromopyridine;N-(6-Bromopyridin-2-yl)acetamide;AcetaMide,N-(6-broMo-2-pyridinyl)-
- CBNumber
- CB81501669
- Molecular Formula
- C7H7BrN2O
- Formula Weight
- 215.05
- MOL File
- 25218-99-9.mol
N-(6-Bromopyridin-2-yl)acetamide Property
- Melting point:
- 157.4 °C
- Boiling point:
- 389.6±27.0 °C(Predicted)
- Density
- 1.630±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.15±0.70(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- A143800
- Product name
- 2-Acetamido-6-bromopyridine
- Packaging
- 10g
- Price
- $370
- Updated
- 2021/12/16
- Product number
- 414819
- Product name
- 2-Acetamido-6-bromopyridine
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
- Product number
- FA146278
- Product name
- 2-Acetamido-6-bromopyridine
- Packaging
- 5G
- Price
- $410
- Updated
- 2021/12/16
- Product number
- V4683
- Product name
- 2-Acetamido-6-bromopyridine
- Packaging
- 10g
- Price
- $477
- Updated
- 2021/12/16
- Product number
- FA146278
- Product name
- 2-Acetamido-6-bromopyridine
- Packaging
- 250mg
- Price
- $52.5
- Updated
- 2021/12/16
N-(6-Bromopyridin-2-yl)acetamide Chemical Properties,Usage,Production
Uses
2-Acetamido-6-bromopyridine is a chemical reagent used in the synthesis of diarylureas used as allosteric modulators. Also used in the prouction of novel Bcl-Abl inhibitors with flexible linkers.
Synthesis
19798-81-3
75-36-5
25218-99-9
I. General procedure for the synthesis of N-(6-bromopyridin-2-yl)acetamide: Step a: To a solution of 6-bromopyridin-2-amine (10 g, 0.060 mol) and triethylamine (Et3N, 25 g, 0.27 mol) in dichloromethane (CH2Cl2, 300 mL) was slowly added acetyl chloride (AcCl, 13 g, 0.17 mol) at 0°C. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (EtOAc, 200 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to afford N-(6-bromopyridin-2-yl)acetamide (88% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.15 (d, J = 8.0 Hz, 1H), 7.97 (brs, 1H), 7.55 (t, J = 8.0 Hz, 1H), 7.18 (d, J = 8.0 Hz, 1H), 2.19 (s, 3H).
References
[1] Patent: WO2012/119979, 2012, A1. Location in patent: Page/Page column 34-35
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 15, p. 4730 - 4743
[3] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 84
[4] Patent: US2004/92741, 2004, A1. Location in patent: Page 4
[5] Patent: US2009/176842, 2009, A1. Location in patent: Page/Page column 13
N-(6-Bromopyridin-2-yl)acetamide Preparation Products And Raw materials
Raw materials
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