Methyl 2-(hydroxymethyl)acrylate

Product Name: Methyl 2-(hydroxymethyl)acrylate
CAS No.: 15484-46-5
Chemical Name: Methyl 2-(hydroxymethyl)acrylate
Synonyms: Methyl 2-(hydroxymethyl);Methyl 2-(hydroxymethyl)acrylate;Methyl 2-(hydroxymethyl)-2-propenoate;2-Hydroxymethyl-acrylic acid methyl ester;2-Propenoic acid, 2-(hydroxyMethyl)-, Methyl ester;Methyl 2-(hydroxymethyl)acrylate, stabilied with BHT;Methyl 2-(hydroxymethyl)acrylate,97%(stabilized with MEHQ);Methyl-2-(Hydroxymethyl)Acrylate(Telbivudine Intermediate);Methyl 2-(hydroxyMethyl)acrylate, stabilized with 0.1 wt.% MEHQ;Methyl 2-(hydroxyMethyl)acrylate, 93%, stabilized with 0.1 wt.% MEHQ
CBNumber: CB81513585
Molecular Formula: C5H8O3
Formula Weight: 116.12
MOL File: 15484-46-5.mol

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Methyl 2-(hydroxymethyl)acrylate Property

Boiling point:: 63-65 °C(Press: 2.3 Torr)
Density: 1.129 g/mL at 25 °C
refractive index: n20/D1.456
Flash point:: 90℃
storage temp.: 2-8°C
pka: 13.66±0.10(Predicted)
form: liquid
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C5H8O3/c1-4(3-6)5(7)8-2/h6H,1,3H2,2H3
InChIKey: RFUCOAQWQVDBEU-UHFFFAOYSA-N
SMILES: C(OC)(=O)C(CO)=C

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Safety

RIDADR: NA 1993 / PGIII
WGK Germany: 1
HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 734349
Product name: Methyl 2-(hydroxymethyl)acrylate
Purity: contain inhibitor
Packaging: 5g
Price: $71.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 734349
Product name: Methyl 2-(hydroxymethyl)acrylate
Purity: contain inhibitor
Packaging: 1g
Price: $28.2
Updated: 2023/06/20

TRC

Product number: M323535
Product name: Methyl 2-(hydroxymethyl)acrylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2329-1-05
Product name: Methyl 2-(hydroxymethyl)acrylate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 119211
Product name: Methyl 2-(hydroxymethyl)acrylate
Purity: 95+%
Packaging: 5g
Price: $82
Updated: 2021/12/16

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Methyl 2-(hydroxymethyl)acrylate Chemical Properties,Usage,Production

Synthesis

50-00-0

5927-18-4

15484-46-5

Example 106: Synthesis of methyl 2-(hydroxymethyl)acrylate Trimethylphosphonoacetate (5.46 g, 30 mmol, 1.0 eq.) was dissolved in an appropriate amount of solvent at room temperature with rapid stirring. Subsequently, saturated K2CO3 aqueous solution (10 mL, 3.5 g, 117 mmol, 1.6 equiv) was added slowly. Next, paraformaldehyde (6.63 g, 48 mmol, 4.0 eq.) was added. After the addition was completed, the reaction mixture continued to be stirred for 2 hours. After completion of the reaction, the mixture was extracted with dichloromethane (DCM). The organic layers were combined and concentrated to give the target product methyl 2-(hydroxymethyl)acrylate (1.5 g, 44% yield) as a yellow oil. The product was characterized by 1H NMR (400 MHz, CD3OD) with the following chemical shifts: δ 6.29 (s, 1H), 5.83 (s, 1H), 3.75 (s, 3H), 3.72 (s, 2H).

References

[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 6, p. 1929 - 1932
[2] Angew. Chem., 2015, vol. 127, # 6, p. 1949 - 1952,4
[3] Tetrahedron, 2008, vol. 64, # 17, p. 3701 - 3712
[4] Patent: WO2011/17561, 2011, A1. Location in patent: Page/Page column 72
[5] Journal of Medicinal Chemistry, 1998, vol. 41, # 18, p. 3539 - 3545

Methyl 2-(hydroxymethyl)acrylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-(hydroxymethyl)acrylate Suppliers

China 117 India 3 United Kingdom 2 United States 11 Global 133

Z IntellecChem& Tech. Co., Ltd

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Energy Chemical

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View Lastest Price from Methyl 2-(hydroxymethyl)acrylate manufacturers

Henan Fengda Chemical Co., Ltd

Product: Methyl 2-(hydroxymethyl)acrylate 15484-46-5
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

Honest Joy Holdings Limited

Product: Methyl 2-(hydroxymethyl)acrylate 15484-46-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.7%
Supply Ability: 100 tons
Release date: 2022-02-08

Career Henan Chemical Co

Product: Methyl 2-(hydroxymethyl)acrylate 15484-46-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

15484-46-5, Methyl 2-(hydroxymethyl)acrylateRelated Search:

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Methyl 2-(hydroxymethyl)acrylate

Methyl 2-(hydroxyMethyl)acrylate, stabilized with 0.1 wt.% MEHQ

2-Propenoic acid, 2-(hydroxyMethyl)-, Methyl ester

Methyl 2-(hydroxyMethyl)acrylate, 93%, stabilized with 0.1 wt.% MEHQ

Methyl 2-(hydroxymethyl)

2-Hydroxymethyl-acrylic acid methyl ester

Methyl 2-(hydroxymethyl)-2-propenoate

Methyl-2-(Hydroxymethyl)Acrylate(Telbivudine Intermediate)

Methyl 2-(hydroxymethyl)acrylate,97%(stabilized with MEHQ)

Methyl 2-(hydroxymethyl)acrylate, stabilied with BHT

15484-46-5

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