Sodium ascorbate Property

Melting point:

220 °C (dec.)(lit.)

alpha 

104 º (c=1, H2O 25 ºC)

Boiling point:

235 °C

Density 

1.66

vapor pressure 

0Pa at 25℃

refractive index 

105.5 ° (C=10, H2O)

storage temp. 

2-8°C

solubility 

H₂O: 50 mg/mL

form 

powder

color 

white to slightly yellow

Odor

odorless

PH

7.48(1 mM solution);7.71(10 mM solution);7.64(100 mM solution);7.62(1000 mM solution)

optical activity

[α]20/D +105±2°, c = 5% in H2O

Water Solubility 

620 g/L (20 ºC)

Merck 

14,830

BRN 

3767246

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

-4.2 at 21.9℃

CAS DataBase Reference

134-03-2(CAS DataBase Reference)

EPA Substance Registry System

Sodium ascorbate (134-03-2)

Safety

Risk Statements 

68

Safety Statements 

24/25

WGK Germany 

1

RTECS 

CI7671000

TSCA 

Yes

HS Code 

29362700

Hazardous Substances Data

134-03-2(Hazardous Substances Data)

Toxicity

sce-hmn:lym 100 mmol/L MUREAV 60,321,79

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Sodium ascorbate Chemical Properties,Usage,Production

Description

Sodium ascorbate is sodium salt of ascorbic acid (commonly known as vitamin C), which is approved for use as a food additive in many countries. Sodium ascorbate is consisted of a combination of sodium and vitamin C, which commonly serve as an antioxidant and an acidity regulator in pharmaceutical manufacturing and in the food industry. In this mixture, sodium acts as a buffer, creating a less acidic supplement than those made entirely from vitamin C. It can be easier to tolerate if the digestive system is sensitive to acid. As a vitamin C supplement, it provides both sodium and vitamin C for human body, which is effective to prevent or treat vitamin C deficiency. Besides, studies have shown that taking sodium ascorbate is helpful with cancer prevention and treatment.

References

https://en.wikipedia.org/wiki/Sodium_ascorbate
http://www.livestrong.com/article/348175-what-are-the-health-benefits-of-sodium-ascorbate/
http://pets.webmd.com/drugs/2/drug-63684/ascorbic-acid-ascorbate-sodium-oral/details

Chemical Properties

Sodium ascorbate occurs as a white or slightly yellow-colored, practically odorless, crystalline powder with a pleasant saline taste.

Uses

Sodium Ascorbate is an antioxidant that is the sodium form of ascorbic acid. it is soluble in water and provides a nonacidic taste. a 10% aqueous solution has a ph of 7.3–7.6. in water, it readily reacts with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant. one part sodium ascorbate is equivalent to 1.09 parts of sodium erythorbate. see ascorbic acid.

Uses

L-Ascorbic acid (Vitamin C) is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress.

Uses

As antimicrobial and antioxidant in foodstuffs.

Definition

ChEBI: Sodium ascorbate is an organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion. It has a role as a food antioxidant, a flour treatment agent, a coenzyme, a plant metabolite, a human metabolite, a Daphnia magna metabolite and a reducing agent. It is an organic sodium salt and a vitamin C. It contains a L-ascorbate.

Production Methods

An equivalent amount of sodium bicarbonate is added to a solution of ascorbic acid in water. Following the cessation of effervescence, the addition of propan-2-ol precipitates sodium ascorbate.

brand name

Ascorbin (Marion Merrell Dow).

General Description

Minute crystals or white powder. pH of aqueous solutions 5.6 to 7.0 or even higher (a 10% solution, made from a commercial grade, may have a pH of 7.4 to 7.7).

Air & Water Reactions

Water soluble. Aqueous solutions are subject to quick air oxidation at pH greater than 6.0.

Reactivity Profile

A weak base. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

SYMPTOMS: Ingestion of 10 grams or more of this type of compound may cause diarrhea.

Fire Hazard

Flash point data for Sodium ascorbate are not available. Sodium ascorbate is probably combustible.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Sodium ascorbate is used as an antioxidant in pharmaceutical formulations, and also in food products where it increases the effectiveness of sodium nitrite against growth of Listeria monocytogenes in cooked meats. It improves gel cohesiveness and sensory firmness of fiberized products regardless of vacuum treatment.
It is also used therapeutically as a source of vitamin C in tablets and parenteral preparations.

Biochem/physiol Actions

Ascorbic acid exhibits anti-oxidant properties. It is a primary substrate for detoxifying hydrogen peroxide. Ascorbic acid is a co-factor for the synthesis of adrenal steroids and catecholamines. L-Ascorbic acid (Vitamin C) is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress. L-Ascorbate can be regenerated by biological systems.

Safety Profile

Human mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.

Safety

The parenteral administration of 0.25-1.00 g of sodium ascorbate, given daily in divided doses, is recommended in the treatment of vitamin C deficiencies. Various adverse reactions have been reported following the administration of 1 g or more of sodium ascorbate, although ascorbic acid and sodium ascorbate are usually well tolerated; see Ascorbic acid. There have been no reports of adverse effects associated with the much lower concentrations of sodium ascorbate and ascorbic acid, which are employed as antioxidants.
The WHO has set an acceptable daily intake of ascorbic acid, potassium ascorbate, and sodium ascorbate, as antioxidants in food, at up to 15 mg/kg body-weight in addition to that naturally present in food.

storage

Sodium ascorbate is relatively stable in air, although it gradually darkens on exposure to light. Aqueous solutions are unstable and subject to rapid oxidation in air at pH > 6.0.
The bulk material should be stored in a well-closed nonmetallic container, protected from light, in a cool, dry place.

Incompatibilities

Incompatible with oxidizing agents, heavy metal ions, especially copper and iron, methenamine, sodium nitrite, sodium salicylate, and theobromine salicylate. The aqueous solution is reported to be incompatible with stainless steel filters.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IV preparations; oral tablets). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.