3-bromo-1H-pyrrolo[3,2-b]pyridine
- Product Name
- 3-bromo-1H-pyrrolo[3,2-b]pyridine
- CAS No.
- 23688-47-3
- Chemical Name
- 3-bromo-1H-pyrrolo[3,2-b]pyridine
- Synonyms
- 3-BROMO-4-AZAINDOLE;3-bromo-1H-pyrrolo[3,2-b]pyridine;1H-Pyrrolo[3,2-b]pyridine, 3-bromo-
- CBNumber
- CB81558744
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 23688-47-3.mol
3-bromo-1H-pyrrolo[3,2-b]pyridine Property
- Melting point:
- 232-238 °C
- Boiling point:
- 346.3±22.0 °C(Predicted)
- Density
- 1.770±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 12.99±0.40(Predicted)
- color
- Yellow to brown
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B446715
- Product name
- 3-Bromo-1H-pyrrolo[3,2-b]pyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR30680
- Product name
- 3-Bromo-4-azaindole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- 3H32-9-W8
- Product name
- 3-Bromo-4-azaindole
- Packaging
- 250mg
- Price
- $47
- Updated
- 2021/12/16
- Product number
- FB144039
- Product name
- 3-Bromo-1H-pyrrolo[3,2-b]pyridine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B10796
- Product name
- 3-Bromo-4-azaindole
- Purity
- 95%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
3-bromo-1H-pyrrolo[3,2-b]pyridine Chemical Properties,Usage,Production
Synthesis
272-49-1
23688-47-3
Example 3 Synthesis of 3-bromo-4-azaindole: 0.9707 g (8.21 mmol) of 4-azaindole was dissolved in 50 mL of acetonitrile in a 250 mL three-necked, round-bottomed flask equipped with a magnetic stirrer, a thermocouple, a nitrogen inlet, and an ice bath cooling device. At 170 °C, 5.5187 g (24.7 mmol, 3 eq.) of solid CuBr2 was added to the flask in batches over 10 min. The reaction mixture formed a green suspension and was stirred at room temperature until the TLC assay showed the disappearance of the raw material (about 1-2 hours). The reaction mixture was cooled to 10 °C and quenched by slowly adding 60 mL of a methanol solution of 7N ammonia. The resulting blue solution was concentrated by rotary evaporation at room temperature and the residue was extracted with ethyl acetate (3 x 80 mL). The organic phases were combined, dried with Na2SO4, filtered and concentrated by rotary evaporation to give 1.4 g of an off-white solid. The solid was suspended in 100 mL of hexane, filtered and dried in vacuum to give 1.225 g (76% yield) of 3-bromo-4-azaindole as a white solid.
References
[1] Patent: US2008/9514, 2008, A1. Location in patent: Page/Page column 26
[2] Patent: WO2010/33980, 2010, A2. Location in patent: Page/Page column 28
[3] Synlett, 2007, # 2, p. 211 - 214
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3238 - 3242
[5] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2430 - 2433
3-bromo-1H-pyrrolo[3,2-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-bromo-1H-pyrrolo[3,2-b]pyridine manufacturers
- Product
- 3-bromo-1H-pyrrolo[3,2-b]pyridine 23688-47-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-23