TCPOBOP

ChemicalBook > CAS DataBase List > TCPOBOP

Product Name: TCPOBOP
CAS No.: 76150-91-9
Chemical Name: TCPOBOP
Synonyms: TCPOBOP;3,3',5,5'-TETRACHLORIDE-BPB;TCPOBOP - CAS 76150-91-9 - Calbiochem;inhibit,Bcl-2 Family,TCPOBOP,Inhibitor;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene;3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE;1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene;3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
CBNumber: CB8155924
Molecular Formula: C16H8Cl4N2O2
Formula Weight: 402.06
MOL File: 76150-91-9.mol

Less

TCPOBOP Property

Boiling point:: 444.8±45.0 °C(Predicted)
Density: 1.518±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10 mg/mL
form: solid
pka: -0.52±0.10(Predicted)
color: white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: UT7145000

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T1443
Product name: TCPOBOP
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $80.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 580563
Product name: TCPOBOP
Packaging: 25mg
Price: $124.8
Updated: 2024/03/01

Cayman Chemical

Product number: 14140
Product name: TCPOBOP
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 14140
Product name: TCPOBOP
Purity: ≥95%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 14140
Product name: TCPOBOP
Purity: ≥95%
Packaging: 25mg
Price: $151
Updated: 2024/03/01

Less

TCPOBOP Chemical Properties,Usage,Production

Description

TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.

Uses

TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.

General Description

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.

Biochem/physiol Actions

TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.

References

1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893

TCPOBOP Preparation Products And Raw materials

Raw materials

Preparation Products

Less

TCPOBOP Suppliers

China 56 Switzerland 1 Ukraine 1 United Kingdom 3 United States 14 Global 75

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-66110311 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15527
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 2414
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9989
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 2717893647 14768611851
Email: 486064515@qq.com
Country: China
ProdList: 1050
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 61720
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6712
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24023
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 3001
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10678
Advantage: 58

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9849
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48467
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32686
Advantage: 60

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43348
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49739
Advantage: 58

Wuhan Boot Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6829
Advantage: 58

Beijing Baiao Innovation Technology Co., Ltd.

Tel: --
Fax: --
Email: 3007606172@qq.com
Country: CHINA
ProdList: 6005
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6942
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6039
Advantage: 58

Shanghai Yuqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 847627550@qq.com
Country: CHINA
ProdList: 6087
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6530
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6618
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6852
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6921
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6011
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6673
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6164
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 1472
Advantage: 58

Beijing Xiangsheng Xingye Technology Co., Ltd.

Tel: --
Fax: --
Email: xs_bio@163.com
Country: CHINA
ProdList: 5130
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6172
Advantage: 58

Qingdao Jieshikang Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: jskangchina@163.com
Country: CHINA
ProdList: 4012
Advantage: 58

Beijing Bi Orange Blue Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: bo49855987@163.com
Country: CHINA
ProdList: 6827
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6322
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Shanghai Yijie Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: SHYIJIEBIO@126.COM
Country: CHINA
ProdList: 3510
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6192
Advantage: 58

Beijing Zhijie Fangyuan Technology Co., Ltd.

Tel: --
Fax: --
Email: 15810200961@163.com
Country: CHINA
ProdList: 6984
Advantage: 58

76150-91-9, TCPOBOPRelated Search:

TYRPHOSTIN AG 879 AG 490 (+)-Camptothecin Brefeldin A TCPOBOP 580563, [3H] TCPOBOP 580563 3-CHLORO-2-METHOXYPYRIDINE 3,5-Dichloropyridine 3,5-DICHLORO-2-PYRIDONE TCPOBOP 3-Chloropyridin-2-ol 5-Chloro-2-methoxypyridine 5-CHLORO-2-HYDROXYPYRIDINE

3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE

3,3',5,5'-TETRACHLORIDE-BPB

1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE

TCPOBOP

2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin

1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene

1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene

1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene

TCPOBOP - CAS 76150-91-9 - Calbiochem

1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene

2,2'-(4,1-Phenylenebisoxy)bis(3,5-dichloropyridine)

2,2'-(p-Phenylenebisoxy)bis(3,5-dichloropyridine)

2,2'-[Benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine)

3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene

3,5-dichloro-2-{4-[(3,5-dichloropyridin-2-yl)oxy]phenoxy}pyridine

Pyridine, 2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro-

inhibit,Bcl-2 Family,TCPOBOP,Inhibitor

76150-91-9

C16H8N2O2Cl4

C16H8Cl4N2O2

Apoptosis and Cell Cycle

Cell Cycle Regulators

Cell Cycle

Cell Biology

Cell Signaling and Neuroscience

BioChemical