TCPOBOP
- Product Name
- TCPOBOP
- CAS No.
- 76150-91-9
- Chemical Name
- TCPOBOP
- Synonyms
- TCPOBOP;3,3',5,5'-TETRACHLORIDE-BPB;TCPOBOP - CAS 76150-91-9 - Calbiochem;inhibit,Bcl-2 Family,TCPOBOP,Inhibitor;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene;3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE;1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene;3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
- CBNumber
- CB8155924
- Molecular Formula
- C16H8Cl4N2O2
- Formula Weight
- 402.06
- MOL File
- 76150-91-9.mol
TCPOBOP Property
- Boiling point:
- 444.8±45.0 °C(Predicted)
- Density
- 1.518±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10 mg/mL
- form
- solid
- pka
- -0.52±0.10(Predicted)
- color
- white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- UT7145000
N-Bromosuccinimide Price
- Product number
- T1443
- Product name
- TCPOBOP
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $80.7
- Updated
- 2024/03/01
- Product number
- 580563
- Product name
- TCPOBOP
- Packaging
- 25mg
- Price
- $124.8
- Updated
- 2024/03/01
- Product number
- 14140
- Product name
- TCPOBOP
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 14140
- Product name
- TCPOBOP
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 14140
- Product name
- TCPOBOP
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $151
- Updated
- 2024/03/01
TCPOBOP Chemical Properties,Usage,Production
Description
TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.
Uses
TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.
General Description
A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
Biochem/physiol Actions
TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.
References
1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893