16a,17a-Epoxyprogesterone

Product Name: 16a,17a-Epoxyprogesterone
CAS No.: 1097-51-4
Chemical Name: 16a,17a-Epoxyprogesterone
Synonyms: W-oxide;ZK-5197;Wobbe's oxide;Waugh's oxide;Albright oxide;Wolfowitz oxide;EPOXY PROGESTERONE;16a,17a-Epoxyprogest;16,17-EPOXYPROGESTERONE;16-17A-Epoxyprogesterone
CBNumber: CB8156077
Molecular Formula: C21H28O3
Formula Weight: 328.45
MOL File: 1097-51-4.mol

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16a,17a-Epoxyprogesterone Property

Melting point:: 200C
Boiling point:: 466.9±45.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
refractive index: 168 ° (C=1, CHCl3)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform, Methanol
form: Solid
color: Off-White
CAS DataBase Reference: 1097-51-4(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: TU5022000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E589580
Product name: 16α,17α-Epoxyprogesterone
Packaging: 25g
Price: $250
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 94327
Product name: 16α,17α-Epoxyprogesterone
Packaging: 2.5g
Price: $375
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0017583
Product name: 16,17-ALPHA-EPOXYPROGESTERONE
Purity: 95.00%
Packaging: 5MG
Price: $550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0017583
Product name: 16,17-ALPHA-EPOXYPROGESTERONE
Purity: 95.00%
Packaging: 1G
Price: $945.95
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0017583
Product name: 16,17-ALPHA-EPOXYPROGESTERONE
Purity: 95.00%
Packaging: 5G
Price: $1370.41
Updated: 2021/12/16

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16a,17a-Epoxyprogesterone Chemical Properties,Usage,Production

Uses

16α,17α-Epoxyprogesterone is hydrolyzed by Rhizopus nigricans for the synthesis of many steroidal drugs.

Definition

ChEBI: 16-alpha,17-Epoxypregn-4-ene-3,20-dione is a corticosteroid hormone.

Synthesis

2872-76-6

1097-51-4

The general procedure for the synthesis of 16,17-epoxyprogesterone from the compound (CAS: 2872-76-6) was as follows: 0.496 g of compound (III) (1.5 × 10^-3 mol) was dissolved in 30 mL of acetone and the reaction system was cooled to 0 °C. Subsequently, 0.48 mL of conditioned Jones' reagent was slowly added (preparation of Jones' reagent: 2.67 g of CrO3 was dissolved in 2.3 mL of concentrated sulfuric acid and then diluted to 10 mL with water). After stirring the reaction mixture for 1 h at 0 °C, the progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was completed. Upon completion of the reaction, 0.5 mL of isopropanol was added to the system to quench the reaction, followed by distillation under reduced pressure to remove the acetone. The reaction mixture was extracted three times with 20 mL of ethyl acetate and the organic phases were combined. The organic phase was washed sequentially with saturated sodium bicarbonate solution and saturated brine, and then dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography to afford 0.446 g of white solid 16α,17α-epoxypregn-4-ene-3,20-dione (IV) in 90.6% isolated yield.

References

[1] Patent: CN104610421, 2017, B. Location in patent: Paragraph 0015; 0036; 0037; 0038; 0039

16a,17a-Epoxyprogesterone Preparation Products And Raw materials

Raw materials

Diosgenin Aluminium isopropoxide Cyclohexanone

Preparation Products

21-Iodo-16-methylpregna-1,4,9(11)-trien-17-ol-3,20-dione 3-ethoxy-17-hydroxypregna-3,5-dien-20-one 17-acetate CORTISONE 16-Methylpregna-1,4,9(11)-trien-17-ol-3,20-dione 17-Hydroxy-21-iodoprogesterone 16-Bromo-17-hydroxypregn-4-en-3,20-dione 3,20-Dioxopregn-4-en-17-beta-yl acetate 3,17-DIHYDROXY-PREGNA-3,5-DIEN-20-ONE DIACETATE Cortisone acetate Megestrol acetate 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate

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16a,17a-Epoxyprogesterone Suppliers

China 199 China Hong Kong 1 Europe 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 9 United States 25 Global 242

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View Lastest Price from 16a,17a-Epoxyprogesterone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 16a,17a-Epoxyprogesterone 1097-51-4
Price: US $665.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1T
Release date: 2020-07-06

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: 16a,17a-Epoxyprogesterone 1097-51-4
Price: US $0.00/GK
Min. Order: 1g
Purity: 99%
Supply Ability: 5kg
Release date: 2020-10-23

Cangzhou Wanyou New Material Technology Co.,Ltd

Product: 16,17a-Epoxy-Progesterone 1097-51-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100 Metric Ton/Metric Tons per Month
Release date: 2019-07-09

1097-51-4, 16a,17a-EpoxyprogesteroneRelated Search:

Medroxyprogesterone Acetate Progesterone Resin epoxy 16,17-Epoxypregn-4-ene-3,11,20-trione 11a-Hydroxy-16,17a-epoxyprogesterone 16,17-EPOXY DOC ACETATE 4-PREGNEN-16ALPHA,17ALPHA-EPOXY-11BETA-OL-3,20-DIONE EPOXY 16a,17a-Epoxyprogesterone

16,17-Epoxypregn-4-ene-3,20-dione

16-alpha,17-epoxy-pregn-4-ene-20-dione

16-alpha,17-epoxypregn-4-ene-3,20-dione

16,17-EPOXYPROGESTERONE

16,17-ALPHA-EPOXYPROGESTERONE

16a,17a-epoxy-4-pregnen-3,20-dione

17-epoxy-20-dion(16-alpha)-pregn-4-ene-16

W-oxide

Pregn-4-ene-3,20-dione,16,17-epoxy-, (16a)-

16A,17A-EPOXY PROGESTERONE

16ALPHA,17ALPHA-EPOXYPROGESTERONE

16ALPHA,17ALPHA-EPOXY-4-PREGNEN-3,20-DIONE

16ALPHA,17ALPHA-EPOXY-4-PREGNENE-3,20-DIONE

16ALPHA-17ALPHA-EPOXY-DELTA4-PREGNEN-3,20-DIONE

4-PREGNEN-16,17-EPOXY-3,20-DIONE

4-PREGNEN-16ALPHA,17ALPHA-EPOXY-3,20-DIONE

(8R,9S,10R,13S,14S,16R,17S)-17-ACETYL-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-20-OXA-CYCLOPROPA[16,17]CYCLOPENTA[A]PHENANTHREN-3-ONE

16-17A-Epoxyprogesterone

16,17-ALPHA-EPOXYPROGESTERONE(EPOXYPREGNENOENE)

16 alpha,17-epoxyprogesterone

16α,17α-Epoxy-4-pregnen-3,20-dione

ZK-5197

16a,17a-Epoxyprogest

EPOXY PROGESTERONE

16,17a-Epoxyprogesterone

Wolfowitz oxide

16a,17a-Epoxyprogesterone 16a,17a-Epoxy-4-pregnen-3,20-dione

16,17a-Epoxy-progesgerone

Albright oxide

(6aR,6bS,8aS,8bS,9aR,10aS,10bR)-8b-acetyl-6a,8a-dimethyl-5,6,6a,6b,7,8,8a,8b,9a,10,10a,10b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]oxiren-4(2H)-one

(6AR,6bS,8aS,8bS,9aR,10aS,10bR)-8b-acetyl-6a,8a-dimethyl-5,6,6a,6b,7,8,8a,8b,9a,10,10a,10b-dod

16,17-Epoxyprogesterone&gt

Pregn-4-ene-3,20-dione, 16,17-epoxy-, (16α)-

Medroxyprogesterone Acetate Impurity 14

DEHYROGENATED-1 1-HYDROXTY-16,17-EXPOXY PROGESTERONE

16α,17α-Epoxyprogesterone

(16α)-16,17-Epoxypregn-4-ene-3,20-dione

Medroxyprogesterone Acetate Impurity 6

Wobbe's oxide

16-alpha,17-epoxy-pregn-4-ene-20-dione 16-alpha,17-epoxypregn-4-ene-3

Waugh's oxide

16α,17α-Epoxy-4-Pregnene-3,20-Dione

16a,17a-Epoxy-4-Pregnen-3,20-Dione, 10 mM in DMSO

16α,17α-Epoxyprogesterone, CAS 1097-51-4

16a,17a-Epoxyprogesteron

1097-51-4

Steroids

Steroids (Others)

Biochemistry

Steroids

Steroids (Others)

1097-51-4