ChemicalBook > CAS DataBase List > DI-TERT-BUTYL HYDRAZODICARBOXYLATE

DI-TERT-BUTYL HYDRAZODICARBOXYLATE

Product Name: DI-TERT-BUTYL HYDRAZODICARBOXYLATE
CAS No.: 16466-61-8
Chemical Name: DI-TERT-BUTYL HYDRAZODICARBOXYLATE
Synonyms: di-tert-butyl hydrazine-1,2-dicarboxylate;DI-TERT-BUTYL HYDRAZODIFORMATE;1,2-bis(t-butyloxycarbonyl)hydrazine;SKL269;N,N'-DI-BOC-HYDRAZINE;LABOTEST-BB LT00453977;di-tert-butyl bicarbamate;TERT-BUTYL HYDRAZODIFORMATE;Di-t-butylhydrazodicarboxylate;Di tert butyl azidooxalic acid
CBNumber: CB8157988
Molecular Formula: C10H20N2O4
Formula Weight: 232.28
MOL File: 16466-61-8.mol

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DI-TERT-BUTYL HYDRAZODICARBOXYLATE Property

Melting point:: 123-126 °C (dec.)(lit.)
Boiling point:: 294.6±9.0 °C(Predicted)
Density: 1.064±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 8.73±0.43(Predicted)
form: Powder or Crystalline Powder
color: White
Water Solubility: Insoluble in water.
BRN: 1794023
InChI: InChI=1S/C10H20N2O4/c1-9(2,3)15-7(13)11-12-8(14)16-10(4,5)6/h1-6H3,(H,11,13)(H,12,14)
InChIKey: TYSZETYVESRFNT-UHFFFAOYSA-N
SMILES: N(C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 140465
Product name: Di-tert-butyl hydrazodiformate
Purity: 97%
Packaging: 10g
Price: $129.2
Updated: 2025/07/31

TCI Chemical

Product number: D4224
Product name: Di-tert-butyl Hydrazodicarboxylate
Packaging: 5G
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: D4224
Product name: Di-tert-butyl Hydrazodicarboxylate
Packaging: 25G
Price: $149
Updated: 2025/07/31

TRC

Product number: D422805
Product name: DL-tert-ButylHydrazodicarboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Synthonix

Product number: D31453
Product name: di-tert-butylhydrazine-1,2-dicarboxylate
Purity: 98%
Packaging: 25g
Price: $40
Updated: 2021/12/16

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DI-TERT-BUTYL HYDRAZODICARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Di-tert-butyl hydrazodicarboxylate, is used as starting reagent during the four-step synthesis of the aminobicyclopyrazolone hydrochloride. It was used as reagent during Pd-catalyzed amination reactions of halo-pyridine substrates.

Uses

Di-tert-butyl hydrazodiformate was used as starting reagent during the four-step synthesis of the aminobicyclopyrazolone hydrochloride. It was used as reagent during Pd-catalyzed amination reactions of halo-pyridine substrates.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018

General Description

Di-tert-butyl hydrazodiformate acts as hydrazine substrate during the preparation of protected pyridylhydrazine derivatives.

Synthesis

24424-99-5

16466-61-8

General procedure for the synthesis of di-tert-butyl azodicarboxylate from di-tert-butyl dicarbonate: Hydrazine monohydrate (5.85 g, 85%, 200 mmol) was added dropwise to a methanol solution containing 50 ml of di-tert-butyl dicarbonate (48 g, 220 mmol) over a period of 30 min under ice bath cooling conditions. After the dropwise addition, the reaction mixture was stirred at room temperature for 3 hours. Subsequently, the methanol solvent was removed by rotary evaporator and 250 ml of n-hexane was added to the residue and the resulting white solid was collected by filtration and washed with n-hexane. A final white solid product of 19.34 g was obtained in 84% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 20, p. 2715 - 2717
[2] Chemical Communications, 2011, vol. 47, # 1, p. 373 - 375
[3] Patent: CN104387418, 2016, B. Location in patent: Paragraph 0088; 0089; 0090
[4] Journal of the American Chemical Society, 2012, vol. 134, # 45, p. 18581 - 18584
[5] Patent: WO2014/22454, 2014, A1. Location in patent: Paragraph 0160

DI-TERT-BUTYL HYDRAZODICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DI-TERT-BUTYL HYDRAZODICARBOXYLATE Suppliers

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View Lastest Price from DI-TERT-BUTYL HYDRAZODICARBOXYLATE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: DI-TERT-BUTYL HYDRAZODICARBOXYLATE 16466-61-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: DI-TERT-BUTYL HYDRAZODICARBOXYLATE 16466-61-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: DI-TERT-BUTYL HYDRAZODICARBOXYLATE 16466-61-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

16466-61-8, DI-TERT-BUTYL HYDRAZODICARBOXYLATERelated Search:

Sodium tungstate Methyl 5-thiazolecarboxylate Orotic acid 1,9-Nonanediol 3-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE Benzyl salicylate 2-BROMO-4-FLUORO-1-IODOBENZENE Tris(2-butoxyethyl) phosphate 4-THIOCARBAMOYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-Fluoro-3-nitropyridine 5-CYANO-2-METHYLPYRIDINE 2-Amino-6-chloro-3-nitropyridine DI-TERT-BUTYL HYDRAZODICARBOXYLATE 1,1,2-Tris(tert-butoxycarbonyl)hydrazine BOC,Z-NNH-BOC DI-TERT-BUTYL 1-(TERT-BUTYLTHIO)-1,2-HYDRAZINEDICARBOXYLATE TRI-BOC-HYDRAZINOACETIC ACID Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester

TERT-BUTYL HYDRAZODIFORMATE

N,N'-DI-BOC-HYDRAZINE

LABOTEST-BB LT00453977

DI-TERT-BUTYL HYDRAZODICARBOXYLATE

DI-TERT-BUTYL HYDRAZODIFORMATE

N,N-Di-tert-butoxycarbonylhydrazine~Di-tert-butyl hydrazodiformate~Hydrazine-N,N-dicarboxylic acid di-tert-butyl ester

di-tert-butyl bicarbamate

n,n'-di-tert-butoxycarbonylhydrazine

Di-tert-butyl hydrazodicarboxylate, 98+%

1,2-Bis(tert-butoxycarbonyl)hydrazine

1,2-Hydrazinedicarboxylic acid bis(1,1-dimethylethyl) ester

Hydrazine-1,2-dicarboxylic acid di-tert-butyl ester

Hydrazine-1,2-diylbis(formic acid tert-butyl) ester

N,N'-Bi(carbamic acid tert-butyl) ester

Di-<i>tert</i>-butyl hydrazodiformate

Di-tert-butyl hydrazodiformate 97%

N-(tert-butoxycarbonylamino)carbamic acid tert-butyl ester

tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate

N,N'-Bis(tert-butoxycarbonyl)hydrazine

di-tert-butyl hydrazine-1,2-dicarboxylate

N,N-Di-tert-butoxycarbonylhydrazine~Di-tert-butyl hydrazodiformate~Hydrazine-N,N-dicarboxylic acid di-tert-butyl est

Di-<i>tert</i>-butyl Hydrazodicarboxylate

1,2-Hydrazinedicarboxylic acid, 1,2-bis(1,1-dimethylethyl) ester

Di-tert-butyl hydrazodicarboxylate≥ 98%(GC)

Di-tert-butylHydrazodicarboxylate&gt

Di-tert-butyl 1,2-Hydrazinedicarboxylate

DL-tert-Butyl Hydrazodicarboxylate

SKL269

Di-t-butylhydrazodicarboxylate-98%

1,2-bis(t-butyloxycarbonyl)hydrazine

1,2-Bis(1,1-dimethylethyl) 1,2-hydrazinedicarboxylate

tert-butyl N-(tert-butoxycarbonylamino)carbamate

Di-t-butylhydrazodicarboxylate

Di tert butyl azidooxalic acid

1,2-Hydrazinedicarboxylic acid,di-tert-butyl ester

N,N’-Bis(tert-butoxycarbonyl)hydrazine

Di-tert-butyl hydrazodiformate, 97%

di-tert-butyl hydrazine-1,2-dicarboxylate - [D31453]

di-tert-Butyl hydrazine-1,2-dicarbonate

1,2-Bis(tert-butyl) 1,2-hydrazinedicarboxylate

16466-61-8

6466-61-8

NHCO2CCH332

Organic Building Blocks

Hydrazides

Building Blocks

Carbonyl Compounds