ChemicalBook > CAS DataBase List > 4-Bromo-2-fluorobiphenyl
4-Bromo-2-fluorobiphenyl
- Product Name
- 4-Bromo-2-fluorobiphenyl
- CAS No.
- 41604-19-7
- Chemical Name
- 4-Bromo-2-fluorobiphenyl
- Synonyms
- BFBP;C12HgBrF;cas no.:41604-19-7;Bromo-2-fluorobiphenyl;Flurbiprofen impurityⅠ;Flurbiprofen impurityⅠ;Flurbiprofen Impurity 9;4-BROMO-2-FLUORODIPHENYL;4-BROMO-2-FLUOROBIPHENYL;2-FLUORO-4-BROMO BIPHENYL
- CBNumber
- CB8158970
- Molecular Formula
- C12H8BrF
- Formula Weight
- 251.09
- MOL File
- 41604-19-7.mol
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4-Bromo-2-fluorobiphenyl Property
- Melting point:
- 39-41 °C(lit.)
- Boiling point:
- 175°C 2mm
- Density
- 1.40
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in DMSO, Methanol
- form
- Crystalline Powder or Chunks
- color
- Off-white to pale yellow
- Water Solubility
- insoluble
- BRN
- 2208913
- InChI
- InChI=1S/C12H8BrF/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H
- InChIKey
- HTRNHWBOBYFTQF-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)=CC=C(Br)C=C1F
- CAS DataBase Reference
- 41604-19-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Bromo-2-fluorobiphenyl(41604-19-7)
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Safety
- Hazard Codes
- Xi,Xn,N
- Risk Statements
- 22-36/37/38-20/21/22-50/53-36/38
- Safety Statements
- 36/37/39-36-26-61-60
- RIDADR
- UN 3152 9/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 9
- PackingGroup
- II
- HS Code
- 29036990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 367583
- Product name
- 4-Bromo-2-fluorobiphenyl
- Purity
- 99%
- Packaging
- 10g
- Price
- $51
- Updated
- 2023/01/07
TCI Chemical
- Product number
- B2028
- Product name
- 4-Bromo-2-fluorobiphenyl
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2028
- Product name
- 4-Bromo-2-fluorobiphenyl
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $154
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2028
- Product name
- 4-Bromo-2-fluorobiphenyl
- Purity
- >99.0%(GC)
- Packaging
- 250g
- Price
- $572
- Updated
- 2023/06/20
TRC
- Product number
- B684405
- Product name
- 4-Bromo-2-fluoro-1,1''-biphenyl
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
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4-Bromo-2-fluorobiphenyl Chemical Properties,Usage,Production
Chemical Properties
Pale yellow crystalline
Uses
An intermediate in the preparation of non-steroidal anti-inflammatory drugs as well as other bio-active compounds.
Synthesis
367-24-8
7439-89-6
41604-19-7
General procedure for the synthesis of 4-bromo-2-fluorobiphenyl from 4-bromo-2-fluoroaniline and iron powder: (1) A solution of 96 g (0.50 mol) of crude 4-bromo-2-fluoroaniline and 60.0 g (1.0 mol) of glacial acetic acid in 100 ml of benzene was added dropwise over a period of 7 hours to a mixture of 69.0 g (1.0 mol) of sodium nitrite, 69 ml of water and 700 ml of benzene. The temperature was maintained at 65°C. Subsequently, the reaction mixture was stirred at 65°C for 12 hours under nitrogen protection. Upon completion of the reaction, the cooled mixture was washed twice with 400 mL of 1N hydrochloric acid. Next, 20 g (0.36 mol) of iron powder, 250 mL of methanol and 150 mL (1.8 mol) of concentrated hydrochloric acid were added and heated at reflux for 13 hours. After the reaction solution was cooled, the benzene layer was washed with 490 ml of water and the solvent was evaporated under reduced pressure at 40 °C/40 mmHg. Finally, the dark-colored oily material obtained was distilled at a pressure of 10 mmHg and the fractions with boiling points of 132-141 °C/8 mmHg were collected to give 64.6 g (51.5% yield) of 4-bromo-2-fluorobiphenyl. The product crystallized after inoculation with crystal seed. A variant of the sodium nitrite method was used to synthesize 4-bromo-2-fluorobiphenyl IV1 and the corresponding results were obtained as shown in Table I.
References
[1] Patent: US4443631, 1984, A
[2] Patent: US4518799, 1985, A
4-Bromo-2-fluorobiphenyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-fluorobiphenyl manufacturers
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- 4-Bromo-2-fluorobiphenyl 41604-19-7
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
Shaanxi Dideu New Materials Co. Ltd
- Product
- 4-Bromo-2-fluorobiphenyl 41604-19-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-11
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- 4-Bromo-2-fluorobiphenyl 41604-19-7
- Price
- US $100.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000kg
- Release date
- 2024-08-20
41604-19-7, 4-Bromo-2-fluorobiphenylRelated Search:
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