BOC-TOTA

Product Name: BOC-TOTA
CAS No.: 194920-62-2
Chemical Name: BOC-TOTA
Synonyms: BOC-TOTA;CAS_194920-62-2;BOC-AMINO-PEG3-AMINE;N-Boc-C1-PEG3-C3-NH2;t-boc-N-amido-dPEG??-amine;t-BocNHCH2-PEG3-CH2CH2CH2NH2;t-boc-N-amido-dPEG??-amine (QBD-10225);N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE;BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE;N-Boc-4,7,10-trioxa-1,13-tridecanediamine
CBNumber: CB8159917
Molecular Formula: C15H32N2O5
Formula Weight: 320.42
MOL File: 194920-62-2.mol

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BOC-TOTA Property

Boiling point:: 432.4±35.0 °C(Predicted)
Density: 1.035 g/mL at 20 °C
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate (Slightly)
form: Oil
pka: 12.66±0.46(Predicted)
color: Colourless

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Safety

WGK Germany: 3
F: 10-34
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 93113
Product name: N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Purity: ≥95.0% (NT)
Packaging: 1G
Price: $199
Updated: 2025/07/31

TCI Chemical

Product number: B6622
Product name: N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Packaging: 1G
Price: $96
Updated: 2025/07/31

TRC

Product number: T117535
Product name: tert-Butyl(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate
Packaging: 1g
Price: $115
Updated: 2021/12/16

Iris Biotech GmbH

Product number: BNN1028
Product name: Boc-TOTA
Packaging: 1g
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50423
Product name: Boc-1-amino-4,7,10-trioxa-13-tridecanamine
Packaging: 1g
Price: $150
Updated: 2021/12/16

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BOC-TOTA Chemical Properties,Usage,Production

Description

Boc-TOTA is a linker containing an amino group with a Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.

Uses

Protected linker.

reaction suitability

reagent type: cross-linking reagent

Synthesis

4246-51-9

24424-99-5

194920-62-2

GENERAL STEPS: A solution of di-tert-butyl dicarbonate (1.99 g, 9.12 mmol) in dichloromethane (55 mL + 5 mL of rinse solution) was slowly added dropwise through the addition funnel to a solution of 4,7,10-trioxo-1,13-tridecanediamine (20 mL, 91.2 mmol) in dichloromethane (100 mL) at 0°C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL). The organic and aqueous phases were separated, and the organic phase was washed sequentially with deionized water (3×50 mL) and saturated saline (50 mL), dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure to afford N-BOC-4,7,10-trioxa-1,13-tridecanediamine (2.571 g, 88% yield) as a colorless liquid. Thin layer chromatography (TLC) analysis: Rf = 0.14 (Expanding agent: 10% methanol, 0.5% ammonia in dichloromethane solution).1H-NMR (CDCl3, 400 MHz) data: δ 5.10 (broad single peak, 1H), 3.51-3.64 (multiple peaks, 12H), 3.61 (single peak, 4H), 3.21 (multiple peaks, 2H), 2.79 (triple peak, J = 6.7 Hz, 1H), 1.77-1.68 (multiple peaks, 4H), 1.42 (single peak, 9H) ppm.

IC 50

PEGs

References

[1] Chemical Communications, 2010, vol. 46, # 39, p. 7403 - 7405
[2] Bioconjugate Chemistry, 2013, vol. 24, # 12, p. 2058 - 2066
[3] Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2663 - 2664
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 11, p. 1798 - 1802
[5] European Journal of Organic Chemistry, 2004, # 9, p. 1983 - 2001

BOC-TOTA Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-TOTA Suppliers

China 96 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 12 Global 113

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

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Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

SynChem，Inc

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Email: sales@synchem.com
Country: United States
ProdList: 4697
Advantage: 58

Riedel-de Haen AG

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Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

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Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Carbocore, Inc.

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Email: sales@carbocore.com
Country: United States
ProdList: 1436
Advantage: 60

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

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View Lastest Price from BOC-TOTA manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate 194920-62-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

194920-62-2, BOC-TOTARelated Search:

Methyl sorbate Octa(OtBu)-Glu-OtBu tert-butyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate Tert-butyl N-(5-hydroxy-2,2-dimethylpentyl)carbamate Carbamic acid, (4-bromo-5-fluoro-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, N-(5-hydroxy-4,4-dimethylpentyl)-, 1,1-dimethylethyl ester tert-butyl N-({5H,6H,7H,8H-imidazo[1,2-a]pyrimidin-2-yl}met hyl)carbamate TERT-BUTYL (5-CYANO-2,3-DIHYDRO-1H-INDEN-1-YL)CARBAMATE BOC-TOTA 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE 17-Oxo-6,9,12-trioxa-2,16-diazaeicosanedioic acid 1-(1,1-dimethylethyl)ester

1-(T-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE

1-(TERT-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE

3-[2-(2-(3-(BOC-AMINO)PROPYLOXY)ETHOXY)ETHOXY]PROPYLAMINE

BOC-TOTA

BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE

N-Boc-4,7,10-trioxa-1,13-tridecanediamine >=95.0% (NT)

tert-butyl N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]carbamate

tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy) 194920-62-2

N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

tert-Butyl (3-(2-(2-(3-aMinopropoxy)ethoxy)ethoxy)propyl)carbaMate

CAS_194920-62-2

t-BocNHCH2-PEG3-CH2CH2CH2NH2

BOC-AMINO-PEG3-AMINE

6,9,12-Trioxa-2-azapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester

t-boc-N-amido-dPEG??-amine

N-Boc-C1-PEG3-C3-NH2

<i>N</i>-Boc-4,7,10-trioxa-1,13-tridecanediamine

t-boc-N-amido-dPEG??-amine (QBD-10225)

194920-62-2

peg