4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- Product Name
- 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- CAS No.
- 135721-98-1
- Chemical Name
- 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- Synonyms
- S14506HCl;S 14506 HYDROCHLORIDE;1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride;4-Fluoro-N-(2-(4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl)ethyl)benzaMide hydrochloride;4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- CBNumber
- CB8161035
- Molecular Formula
- C24H27ClFN3O2
- Formula Weight
- 443.94
- MOL File
- 135721-98-1.mol
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Property
- storage temp.
- Desiccate at RT
N-Bromosuccinimide Price
- Product number
- 1771
- Product name
- S14506hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 1771
- Product name
- S14506hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $648
- Updated
- 2021/12/16
- Product number
- 256547
- Product name
- S 14506 hydrochloride
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- S080863
- Product name
- S14506
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- API0008837
- Product name
- 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1291.58
- Updated
- 2021/12/16
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
S 14506 is a full, highly potent and selective SR-1A agonist.
Definition
ChEBI: 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride is a hydrochloride salt that is obtained by reaction of 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide with one equivalent of hydrogen chloride. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. It has a role as a serotonergic agonist and an anxiolytic drug. It contains a 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+).
Biological Activity
Highly potent selective 5-HT 1A receptor full agonist (pK i values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 2 and 5-HT 3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo .
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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