ChemicalBook > CAS DataBase List > HYDROXY ITRACONAZOLE

HYDROXY ITRACONAZOLE

Product Name: HYDROXY ITRACONAZOLE
CAS No.: 112559-91-8
Chemical Name: HYDROXY ITRACONAZOLE
Synonyms: R 63373;HYDROXY ITRACONAZOLE;Itraconazole Impurity 1;Ketoconazole Impurity 36;Itraconazole 2-Hydroxy Metabolite;Hydroxy Itraconazole (10mM in DMSO);Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole);Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole;4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one
CBNumber: CB8173597
Molecular Formula: C35H38Cl2N8O5
Formula Weight: 721.63
MOL File: 112559-91-8.mol

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HYDROXY ITRACONAZOLE Property

Melting point:: 76-78°C
Boiling point:: 884.7±75.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
pka: 14.72±0.20(Predicted)
color: White to Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22576
Product name: Hydroxy Itraconazole
Purity: ≥95% (mixture of diastereomers)
Packaging: 500μg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 22576
Product name: Hydroxy Itraconazole
Purity: ≥95% (mixture of diastereomers)
Packaging: 1mg
Price: $275
Updated: 2024/03/01

Usbiological

Product number: H9090-76
Product name: Hydroxy Itraconazole
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: H943600
Product name: HydroxyItraconazole
Packaging: 25mg
Price: $2110
Updated: 2021/12/16

ChemScene

Product number: CS-4095
Product name: HydroxyItraconazole
Purity: 99.60%
Packaging: 1mg
Price: $252
Updated: 2021/12/16

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HYDROXY ITRACONAZOLE Chemical Properties,Usage,Production

Description

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.

Chemical Properties

Off-White Crystalline Solid

Uses

A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.

in vivo

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view^[1].

References

[1] Y MIKAMI. Comparison of in vitro antifungal activity of itraconazole and hydroxy-itraconazole by colorimetric MTT assay.[J]. Mycoses, 1994, 37 1-2: 27-33. DOI: 10.1111/j.1439-0507.1994.tb00281.x
[2] YASUAKI MINO . Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole[J]. Clinica Chimica Acta, 2013, 415: Pages 128-132. DOI: 10.1016/j.cca.2012.10.028

HYDROXY ITRACONAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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HYDROXY ITRACONAZOLE Suppliers

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112559-91-8, HYDROXY ITRACONAZOLERelated Search:

Itraconazole 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 1-(4-AMINOPHENYL)-4-(4-METHOXYPHENYL)PIPERAZINE trans-Itraconazole N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole KETO ITRACONAZOLE 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl benzoate Des-(1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one) Itraconazole Propyl Itraconazole (1,2,4-Triazol-4-yl) Itraconazole cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Itraconazole Impurity 15 cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate

HYDROXY ITRACONAZOLE

3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-

4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one

R 63373

Itraconazole Impurity 8(Hydroxy Itraconazole)

4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-

Itraconazole 2-Hydroxy Metabolite

Itraconazole metabolite Hydroxy Itraconazole

Itraconazole Impurity 1

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole

4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one

Hydroxy Itraconazole (10mM in DMSO)

Hydroxy Itraconazole D8Q: What is Hydroxy Itraconazole D8 Q: What is the CAS Number of Hydroxy Itraconazole D8 Q: What is the storage condition of Hydroxy Itraconazole D8 Q: What are the applications of Hydroxy Itraconazole D8

Hydroxy ItraconazoleQ: What is Hydroxy Itraconazole Q: What is the CAS Number of Hydroxy Itraconazole Q: What is the storage condition of Hydroxy Itraconazole Q: What are the applications of Hydroxy Itraconazole

Ketoconazole Impurity 36

4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(3-hydroxybutan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

112559-91-8

C35H40Cl2N8O4

C35H38Cl2N8O5

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Various Metabolites and Impurities

Isotooe labelled metabolites

metabolites

Isotopically Labeled Pharmaceutical Reference Standard