ChemicalBook > CAS DataBase List > HYDROXY ITRACONAZOLE

HYDROXY ITRACONAZOLE

Product Name
HYDROXY ITRACONAZOLE
CAS No.
112559-91-8
Chemical Name
HYDROXY ITRACONAZOLE
Synonyms
R 63373;HYDROXY ITRACONAZOLE;Itraconazole Impurity 1;Ketoconazole Impurity 36;Itraconazole 2-Hydroxy Metabolite;Hydroxy Itraconazole (10mM in DMSO);Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole);Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole;4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one
CBNumber
CB8173597
Molecular Formula
C35H38Cl2N8O5
Formula Weight
721.63
MOL File
112559-91-8.mol
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HYDROXY ITRACONAZOLE Property

Melting point:
76-78°C
Boiling point:
884.7±75.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
14.72±0.20(Predicted)
color 
White to Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22576
Product name
Hydroxy Itraconazole
Purity
≥95% (mixture of diastereomers)
Packaging
500μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
22576
Product name
Hydroxy Itraconazole
Purity
≥95% (mixture of diastereomers)
Packaging
1mg
Price
$275
Updated
2024/03/01
Usbiological
Product number
H9090-76
Product name
Hydroxy Itraconazole
Packaging
1mg
Price
$460
Updated
2021/12/16
TRC
Product number
H943600
Product name
HydroxyItraconazole
Packaging
25mg
Price
$2110
Updated
2021/12/16
ChemScene
Product number
CS-4095
Product name
HydroxyItraconazole
Purity
99.60%
Packaging
5mg
Price
$1020
Updated
2021/12/16
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HYDROXY ITRACONAZOLE Chemical Properties,Usage,Production

Description

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.

Chemical Properties

Off-White Crystalline Solid

Uses

A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.

HYDROXY ITRACONAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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112559-91-8, HYDROXY ITRACONAZOLERelated Search:

Itraconazole 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 1-(4-AMINOPHENYL)-4-(4-METHOXYPHENYL)PIPERAZINE trans-Itraconazole N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole KETO ITRACONAZOLE 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl benzoate Des-(1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one) Itraconazole Propyl Itraconazole (1,2,4-Triazol-4-yl) Itraconazole cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Itraconazole Impurity 15 cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate

  • HYDROXY ITRACONAZOLE
  • 3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-
  • 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one
  • R 63373
  • Itraconazole Impurity 8(Hydroxy Itraconazole)
  • 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-
  • Itraconazole 2-Hydroxy Metabolite
  • Itraconazole metabolite Hydroxy Itraconazole
  • Itraconazole Impurity 1
  • Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole
  • 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one
  • Hydroxy Itraconazole (10mM in DMSO)
  • Hydroxy Itraconazole D8Q: What is Hydroxy Itraconazole D8 Q: What is the CAS Number of Hydroxy Itraconazole D8 Q: What is the storage condition of Hydroxy Itraconazole D8 Q: What are the applications of Hydroxy Itraconazole D8
  • Hydroxy ItraconazoleQ: What is Hydroxy Itraconazole Q: What is the CAS Number of Hydroxy Itraconazole Q: What is the storage condition of Hydroxy Itraconazole Q: What are the applications of Hydroxy Itraconazole
  • Ketoconazole Impurity 36
  • 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(3-hydroxybutan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one
  • 112559-91-8
  • C35H40Cl2N8O4
  • C35H38Cl2N8O5
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Various Metabolites and Impurities
  • Isotooe labelled metabolites
  • metabolites
  • Isotopically Labeled Pharmaceutical Reference Standard