4-tert-Butylbenzhydrazide
- Product Name
- 4-tert-Butylbenzhydrazide
- CAS No.
- 43100-38-5
- Chemical Name
- 4-tert-Butylbenzhydrazide
- Synonyms
- 4-TERT-BUTYLBE;AKOS BBS-00004509;BUTTPARK 44\03-79;Butylbenzhydrazide;4-tert-Butylbenzhydr;LABOTEST-BB LT00454438;4-t-Butylbenzhydrazide;4-TERT-BUTYLBENZHYRAZIDE;4-TERT-BUTYLBENZHYDRAZIDE;p-tert-butylbenzohydrazide
- CBNumber
- CB8173739
- Molecular Formula
- C11H16N2O
- Formula Weight
- 192.26
- MOL File
- 43100-38-5.mol
4-tert-Butylbenzhydrazide Property
- Melting point:
- 120-127 °C(lit.)
- Density
- 1.046±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 12.82±0.10(Predicted)
- color
- White to Almost white
- BRN
- 1104663
- InChI
- InChI=1S/C11H16N2O/c1-11(2,3)9-6-4-8(5-7-9)10(14)13-12/h4-7H,12H2,1-3H3,(H,13,14)
- InChIKey
- XYUFQWDLRLHUPB-UHFFFAOYSA-N
- SMILES
- C(NN)(=O)C1=CC=C(C(C)(C)C)C=C1
- CAS DataBase Reference
- 43100-38-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Tert-butylbenzoic acid hydrazide(43100-38-5)
- EPA Substance Registry System
- Benzoic acid, 4-(1,1-dimethylethyl)-, hydrazide (43100-38-5)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 24/25-36/37-26-37
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29280000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 168114
- Product name
- 4-tert-Butylbenzoic hydrazide
- Purity
- 97%
- Packaging
- 25g
- Price
- $90
- Updated
- 2023/01/07
- Product number
- B2886
- Product name
- 4-tert-Butylbenzohydrazide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- B2886
- Product name
- 4-tert-Butylbenzohydrazide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $147
- Updated
- 2025/07/31
- Product number
- T204548
- Product name
- 4-tert-Butylbenzhydrazide
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 056937
- Product name
- 4-tert-Butylbenzhydrazide
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
4-tert-Butylbenzhydrazide Chemical Properties,Usage,Production
Chemical Properties
white to light beige crystalline powder or
Uses
4-tert-Butylbenzoic hydrazide was used in the synthesis of 2-(2-methylphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole.
Synthesis
26537-19-9
43100-38-5
The general procedure for the synthesis of p-tert-butylbenzohydrazide from methyl p-tert-butylbenzoate is as follows: 1. Preparation of raw materials: 40.0 g (0.21 mol) of methyl p-tert-butylbenzoate and 60.0 g (1.20 mol) of hydrazine hydrate were added to a reaction flask containing 120 mL of dioxane. 2. Reaction process: The reaction mixture was heated to reflux for 28 hours. 3. Post-treatment: After completion of the reaction, the mixture was cooled to room temperature and subsequently poured into 1000.0 mL of water. 4. 4. Separation of products: The precipitated white solid was collected by filtration and dried under vacuum. 5. 5. Yield and characterization: 36.0 g of product was obtained in 90.0% yield. The product was characterized by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3) with the following data: 1H NMR δ: 7.67 (d, 2H, J = 8.4 Hz), 7.40 (d, 2H, J = 8.4 Hz), 4.15 (br, 2H, NH2), 1.29 (s, 9H, 3×CH3) ppm. 13C NMR δ: 168.54, 155.38, 129.54, 126.72, 125.57, 34.90, 31.07 ppm.
References
[1] Patent: WO2009/80797, 2009, A1. Location in patent: Page/Page column 25
[2] Letters in Drug Design and Discovery, 2012, vol. 9, # 3, p. 276 - 281
[3] Patent: CN104326980, 2016, B. Location in patent: Paragraph 0059; 0060
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, p. 62 - 69
[5] Chemistry - A European Journal, 2013, vol. 19, # 4, p. 1373 - 1384
4-tert-Butylbenzhydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-tert-Butylbenzhydrazide manufacturers
- Product
- 4-tert-Butylbenzhydrazide 43100-38-5
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-21