Paroxetine hydrochloride
- Product Name
- Paroxetine hydrochloride
- CAS No.
- 78246-49-8
- Chemical Name
- Paroxetine hydrochloride
- Synonyms
- FG-7051;Deroxat;Seroxat;brl29060a;BRL-29060;(3s,4r)-orid;BRL29060 HCl;(3s-trans)-id;PAROXETINE HC;PAROXETINE HCL
- CBNumber
- CB8178022
- Molecular Formula
- C19H21ClFNO3
- Formula Weight
- 365.83
- MOL File
- 78246-49-8.mol
Paroxetine hydrochloride Property
- Melting point:
- 129-131°C
- storage temp.
- 2-8°C
- solubility
- insoluble in H2O; ≥17.8 mg/mL in EtOH; ≥18.29 mg/mL in DMSO
- form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 78246-49-8(CAS DataBase Reference)
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0000578
- Product name
- Paroxetine hydrochloride (anhydrous)
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000578
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 1500218
- Product name
- Paroxetine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 350mg
- Price
- $366
- Updated
- 2021/12/16
- Product number
- 14998
- Product name
- Paroxetine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 14998
- Product name
- Paroxetine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 14998
- Product name
- Paroxetine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $216
- Updated
- 2024/03/01
Paroxetine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Powder
Originator
Paxil, SmithKline Beecham ,France
Uses
Paroxetine is an antidepressant drug of the SSRI type
Uses
A selective serotonin reuptake inhibitor. Used as an antidepressant
Definition
ChEBI: Paroxetine hydrochloride is the hydrochloride salt of paroxetine. It is an antidepressant drug. It has a role as an antidepressant, an anxiolytic drug, a hepatotoxic agent, a P450 inhibitor and a serotonin uptake inhibitor. It contains a paroxetinium(1+).
Manufacturing Process
251 g of methyl-4-(4-fluorophenyl)-N-methyl-nipecotinate, 8 g of sodium methoxide and 500 ml benzene were refluxed for 2 h. The benzene solution was washed with cold water and evaporated to give the pure α-ester which was dissolved in a mixture of 320 ml of water and 450 ml concentrated hydrochloric acid. The solution was slowly distilled to remove methanol and finally evaporated to dryness in vacuo.
400 ml thionyl chloride were added in small portions to the solid. The mixture was allowed to stand for 3 h at room temperature and was then evaporated to dryness in vacuo with tetrachloroethane giving methyl-4-(4-fluorophenyl)-Nmethylnipecotic acid chloride. The acid chloride was added in small portions to a solution of 160 g (-)-menthol in 800 ml pyridine at a temperature of 0°-5°C. The mixture was allowed to stand at room temperature to the next day. Ice water and 50% sodium hydroxide were added, and the mixture was extracted with ether. The ether was dried with anhydrous magnesium sulphate, filtered and evaporated. Distillation in vacuo gave the menthol ester in a yield of 7580%. Boiling point at 0.05 mm Hg was 165°-170°C.
Racemic 4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (50 g) was dissolved in a mixture of 21.6 ml of concentrated sulfuric acid and 50 ml of water. To the solution were added 25 ml of concentrated hydrochloric acid and 22.4 ml of 37% formaldehyde solution. The mixture was refluxed for 5 h, cooled, and 125 ml of concentrated ammonia were added. The mixture was extracted with 50 ml of toluene. Drying of the toluene solution and distillation gave 38 g of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine with boiling point 110°-120°C at 0.1 mm Hg.
13 g of the racemic compound and 22 g of (-)-dibenzoyltartaric acid were dissolved in 105 ml of hot methanol. On cooling, 9 g of salt of (-)-4-(4fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6-tetrahydropyridine crystallized. Melting point 167°-168°C.
38 g of (-)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine were dissolved in 350 ml of 99% ethanol, 5 g of 5% palladium on carbon were added, and the mixture was treated with hydrogen until 4500 ml were absorbed. The catalyst was filtered off, and the solution was evaporated to yield 37.5 g of (+)-b-4-(4-fluorophenyl)-3-hydroxymethyl1-methylpiperidine.
To a solution of sodium in methanol (125 ml) were added 3,4methylenedioxyphenol (29 g) and the (+)-b-4-(4-fluorophenyl)-3hydroxymethyl-1-methylpiperidine (37,5 g). The mixture was stirred and refluxed. After removal of the solvent in vacuo, the evaporation residue was poured into a mixture of ice (150 g), water (150 ml), and ether (200 ml). The ether layer was separated, and the aqueous layer was extracted with ether. The combined ether solutions were washed with water and dried with anhydrous magnesium sulphate, and the ether was evaporated. The residue was triturated with 200 ml of 99% ethanol and 11.5 ml of concentrated hydrochloric acid, yielding 30 g of (-)-b-4-(4-fluorophenyl-3-(1,3-benzdioxolyl(3)-oxymethyl)-1-methylpiperidine, hydrochloride were obtained. Melting point 202°C.
brand name
Paxil (GlaxoSmithKline).
Therapeutic Function
Antidepressant
Biological Activity
paroxetine hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (ssris).paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. paroxetine likely inhibits the reuptake of serotonin at the
storage
Room temperature
Paroxetine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Paroxetine hydrochloride manufacturers
- Product
- Paroxetine Hydrochloride 78246-49-8
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- EP
- Supply Ability
- 20 tons
- Release date
- 2022-08-10
- Product
- Paroxetine hydrochloride 78246-49-8
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-22
- Product
- Paroxetine hydrochloride 78246-49-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-03