ChemicalBook > CAS DataBase List > Paroxetine hydrochloride

Paroxetine hydrochloride

Product Name
Paroxetine hydrochloride
CAS No.
78246-49-8
Chemical Name
Paroxetine hydrochloride
Synonyms
FG-7051;Deroxat;Seroxat;brl29060a;BRL-29060;(3s,4r)-orid;(3s-trans)-id;PAROXETINE HC;PAROXETINE HCL;PAROXETIN X HCL
CBNumber
CB8178022
Molecular Formula
C19H21ClFNO3
Formula Weight
365.83
MOL File
78246-49-8.mol
More
Less

Paroxetine hydrochloride Property

Melting point:
129-131°C
storage temp. 
2-8°C
form 
neat
CAS DataBase Reference
78246-49-8(CAS DataBase Reference)
More
Less

Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1804
Product name
Paroxetine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500 mg
Price
$173
Updated
2021/03/22
Sigma-Aldrich
Product number
Y0000578
Product name
Paroxetine hydrochloride (anhydrous)
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000578
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
1500218
Product name
Paroxetine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
350 mg
Price
$366
Updated
2021/03/22
Cayman Chemical
Product number
14998
Product name
Paroxetine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$39
Updated
2021/03/22
Cayman Chemical
Product number
14998
Product name
Paroxetine (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$93
Updated
2021/03/22
More
Less

Paroxetine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Powder

Originator

Paxil, SmithKline Beecham ,France

Uses

Paroxetine is an antidepressant drug of the SSRI type

Uses

A selective serotonin reuptake inhibitor. Used as an antidepressant

Manufacturing Process

251 g of methyl-4-(4-fluorophenyl)-N-methyl-nipecotinate, 8 g of sodium methoxide and 500 ml benzene were refluxed for 2 h. The benzene solution was washed with cold water and evaporated to give the pure α-ester which was dissolved in a mixture of 320 ml of water and 450 ml concentrated hydrochloric acid. The solution was slowly distilled to remove methanol and finally evaporated to dryness in vacuo.
400 ml thionyl chloride were added in small portions to the solid. The mixture was allowed to stand for 3 h at room temperature and was then evaporated to dryness in vacuo with tetrachloroethane giving methyl-4-(4-fluorophenyl)-Nmethylnipecotic acid chloride. The acid chloride was added in small portions to a solution of 160 g (-)-menthol in 800 ml pyridine at a temperature of 0°-5°C. The mixture was allowed to stand at room temperature to the next day. Ice water and 50% sodium hydroxide were added, and the mixture was extracted with ether. The ether was dried with anhydrous magnesium sulphate, filtered and evaporated. Distillation in vacuo gave the menthol ester in a yield of 7580%. Boiling point at 0.05 mm Hg was 165°-170°C.
Racemic 4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (50 g) was dissolved in a mixture of 21.6 ml of concentrated sulfuric acid and 50 ml of water. To the solution were added 25 ml of concentrated hydrochloric acid and 22.4 ml of 37% formaldehyde solution. The mixture was refluxed for 5 h, cooled, and 125 ml of concentrated ammonia were added. The mixture was extracted with 50 ml of toluene. Drying of the toluene solution and distillation gave 38 g of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine with boiling point 110°-120°C at 0.1 mm Hg.
13 g of the racemic compound and 22 g of (-)-dibenzoyltartaric acid were dissolved in 105 ml of hot methanol. On cooling, 9 g of salt of (-)-4-(4fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6-tetrahydropyridine crystallized. Melting point 167°-168°C.
38 g of (-)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine were dissolved in 350 ml of 99% ethanol, 5 g of 5% palladium on carbon were added, and the mixture was treated with hydrogen until 4500 ml were absorbed. The catalyst was filtered off, and the solution was evaporated to yield 37.5 g of (+)-b-4-(4-fluorophenyl)-3-hydroxymethyl1-methylpiperidine.
To a solution of sodium in methanol (125 ml) were added 3,4methylenedioxyphenol (29 g) and the (+)-b-4-(4-fluorophenyl)-3hydroxymethyl-1-methylpiperidine (37,5 g). The mixture was stirred and refluxed. After removal of the solvent in vacuo, the evaporation residue was poured into a mixture of ice (150 g), water (150 ml), and ether (200 ml). The ether layer was separated, and the aqueous layer was extracted with ether. The combined ether solutions were washed with water and dried with anhydrous magnesium sulphate, and the ether was evaporated. The residue was triturated with 200 ml of 99% ethanol and 11.5 ml of concentrated hydrochloric acid, yielding 30 g of (-)-b-4-(4-fluorophenyl-3-(1,3-benzdioxolyl(3)-oxymethyl)-1-methylpiperidine, hydrochloride were obtained. Melting point 202°C.

brand name

Paxil (GlaxoSmithKline).

Therapeutic Function

Antidepressant

Paroxetine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Paroxetine hydrochloride Suppliers

Taizhou Hoyoo Chemical Co.,Ltd
Tel
0576-88666163-
Fax
0576-88666163
Email
hoyoochem@yahoo.com
Country
China
ProdList
180
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43499
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35909
Advantage
56
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8935
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2950
Advantage
58
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Email
pb@whhz.cn
Country
China
ProdList
1082
Advantage
55
BioBioPha Co., Ltd.
Tel
0871-65217109-
Fax
0871-65215563
Email
sales@mail.biobiopha.com
Country
China
ProdList
5688
Advantage
65
T&W GROUP
Tel
021-61551611-
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9753
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9914
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
25-66112885-
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
9979
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280-
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
21578
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
86-21-58998985
Fax
(86) 21-58955996
Email
apisales@chemexpress.com.cn
Country
China
ProdList
7557
Advantage
61
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8043
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399-
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4575
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3756
Advantage
55
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488- ;27-81302488-
Fax
027-81302088
Email
info@dkybpc.com;2851686510@qq.com
Country
China
ProdList
2025
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712 / 13995564702 / 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3130
Advantage
55
Bide Pharmatech Ltd.
Tel
021-61629020-8031;
Fax
+86-21-61629029
Email
sales@bldpharm.com;product07@bidepharmatech.com
Country
China
ProdList
39458
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785-
Fax
051085625359
Email
sales@reading-chemicals.com;
Country
China
ProdList
15200
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 QQ:3091977954
Fax
027-59420980
Email
dh.luna@whdhwy.com
Country
China
ProdList
4957
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432-
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
13966
Advantage
53
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981/18702770802
Fax
027-83322098
Email
dh.luna@whdhwy.com
Country
China
ProdList
1980
Advantage
50
Wuhan Biocar Bio-Pharm Co., Ltd.
Tel
Fax
86-13343428090
Email
85776233@qq.com
Country
China
ProdList
2000
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
3007
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Email
sales02@forever-reagent.com
Country
China
ProdList
9778
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241- ;027-59599240-
Fax
027-59599241
Email
1400878000@qq.com;1400868000@qq.com
Country
China
ProdList
9841
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2388
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Please Email
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9550
Advantage
50
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
Country
China
ProdList
50837
Advantage
80
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658;QQ 2689309269
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1813
Advantage
58
Hubei kangmingde Pharmaceutical Chemical Co., Ltd
Tel
027-89771658-
Fax
027-89771658
Email
hbtcky@163.com
Country
China
ProdList
4870
Advantage
56
Shanghai Synchem Pharma Co., ltd
Tel
021-61984905-1
Email
synchempharma@aliyun.com
Country
China
ProdList
6136
Advantage
55
Codow Chemical Co.,Ltd.
Tel
1862-009-9427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
18949
Advantage
55
Tianjin Being Technology Co., Ltd.
Tel
Fax
QQ:343281693
Email
tjby921@163.com
Country
China
ProdList
491
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10462
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3872
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312824-
Fax
QQ:3008007432
Email
3008007432@qq.com
Country
China
ProdList
30311
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9965
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9614
Advantage
55
WuHan YuanCheng Gongchuang Technology Co.Ltd
Tel
0531-85067660
Fax
027-88608190-969
Email
gy08@yccreate.com
Country
China
ProdList
2971
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4542
Advantage
58
Roark Standards
Tel
0755-83552066 15986688328
Fax
0755-83552066
Email
service@roarkstandards.com
Country
China
ProdList
1443
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973132-
Email
405465416@qq.com
Country
China
ProdList
22394
Advantage
68
More
Less

View Lastest Price from Paroxetine hydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Paroxetine hydrochloride
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-01-14
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Paroxetine hydrochloride 78246-49-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-08
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Paroxetine hydrochloride 78246-49-8
Price
US $600.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2020-11-02

78246-49-8, Paroxetine hydrochlorideRelated Search:


  • PAROMOMYCINSULFATE
  • (3s,4r)-orid
  • (3s-trans)-id
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,hydrochloride,(3s-trans)-piperidin
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidinhydrochl
  • PAROXETINE HC
  • Paroxetine hydrochloride,trans-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride
  • (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride hemihydrate
  • 5-[[(3S,4R)-4-(4-Fluorophenyl)-3-piperidyl]methoxy]-1,3-benzodioxole·hydrochloride
  • 3-[(1,3-benzodioxol-5-yloxy)meth
  • Paroetine Hydrochloride HeMihydrate
  • (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)Methyl)-4-(4-fluorophenyl)piperidine hydrochloride
  • Paroxetine HCl heMihydrate API
  • Proxetine Hydrochloride
  • Paroxetine HCl Anhydrous
  • (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine, hydrochloride (1:1)
  • Paroxetine HCL USP37
  • Paroxetine hydrochloride, 99%, a selective serotonin-reuptake inhibitor
  • BRL29060 HYDROCHLORIDE;BRL29060A
  • (110429-35-1) paroxetine hydrochloride
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidinhydrochlor
  • brl29060a
  • brl29060hydrochloride
  • BRL-29060
  • FG-7051
  • (3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE
  • (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride
  • PAROXETINE HCL
  • PAROXETINE HYDROCHLORIDE
  • PAROXETIN X HCL
  • (-)TRANS-3-[(1,3-BENZODIOXOL-5-YLOXY) METHYL]-4-(4-FLUOROPHENYL) PAROXETINE HYDROCHLORIDE
  • Paroxetine HCL EP4.5
  • Paroxeting chlorhydric acid
  • ParoxetineHCl.1/2H2O
  • (-)TRANS-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE HYDROCHLORIDE
  • Deroxat
  • Seroxat
  • Piperidine, 3-(1,3-benzodioxol-5-yloxy)methyl-4-(4-fluorophenyl)-, hydrochloride, (3S,4R)-
  • Paroxetine Hydrochloride RS
  • Paroxetine hydrochloride hemihydrate CRS
  • Paroxetine hydrochloride USP/EP/BP
  • 78246-49-8
  • C19H20NO3FHCl
  • C19H20FNO3ClH
  • C19H21ClFNO3
  • C19H20FNO3HClC19H21ClFNO3
  • C20H21FNO3
  • C19H20FNO3HCl
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's
  • Serotonin receptor