ChemicalBook > CAS DataBase List > 4-chloropyrrolo[1,2-f][1,2,4]triazine

4-chloropyrrolo[1,2-f][1,2,4]triazine

Product Name: 4-chloropyrrolo[1,2-f][1,2,4]triazine
CAS No.: 888720-29-4
Chemical Name: 4-chloropyrrolo[1,2-f][1,2,4]triazine
Synonyms: 4-chloropyrrolo[1;4-Chloropyrrolo[1,2-f][1,...;4-Chloropyrrolo[2,1-f][1,2,4]triazine;4-chloropyrrolo[1,2-f][1,2,4]triazine;Pyrrolo[2,1-f][1,2,4]triazine,4-chloro-
CBNumber: CB81856136
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 888720-29-4.mol

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4-chloropyrrolo[1,2-f][1,2,4]triazine Property

Density: 1.51
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.85±0.30(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C380410
Product name: 4-Chloropyrrolo[2,1-f][1,2,4]triazine
Packaging: 100mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20381
Product name: 4-Chloropyrrolo[2,1-f][1,2,4]triazine
Packaging: 50mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20381
Product name: 4-Chloropyrrolo[2,1-f][1,2,4]triazine
Packaging: 100mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: W9184
Product name: 4-Chloropyrrolo[2,1-f][1,2,4]triazine
Packaging: 250mg
Price: $247
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20381
Product name: 4-Chloropyrrolo[2,1-f][1,2,4]triazine
Packaging: 250mg
Price: $300
Updated: 2021/12/16

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4-chloropyrrolo[1,2-f][1,2,4]triazine Chemical Properties,Usage,Production

Uses

4-Chloropyrrolo[1,2-f][1,2,4]triazine is a pyrrolotriazine derivative used in the preparation of kinase inhibitors for treating cancer.

Synthesis

159326-71-3

888720-29-4

General procedure for the synthesis of 4-chloropyrrolo[1,2-f][1,2,4]triazine from pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one: Step 3: Synthesis of 4-chloropyrrolo[1,2-f][1,2,4]triazine Diisopropylethylamine (3.5 mL, 20.3 mmol) was added to a solution of pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one (2.5 g, 18.5 mmol) dissolved in toluene (37.5 mL) under nitrogen protection. Subsequently, phosphorus trichloride (5.1 mL, 55.7 mmol) was added and the reaction mixture was heated at 100 °C for 20 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, aqueous sodium bicarbonate was added slowly and stirred at room temperature for 30 min. The aqueous layer was extracted with ethyl acetate and the organic phase was dried with magnesium sulfate and filtered. The filtrate was concentrated in vacuo to give a yellow solid product which could be used in the next reaction without further purification (2.31 g, 15.0 mmol, 81% yield). 1H NMR (400 MHz, CDCl3) δ: 8.22 (s, 1H), 7.87 (dd, J = 2.4 Hz, 1.6 Hz, 1H), 7.00-6.97 (m, 2H).

References

[1] Patent: US2011/183983, 2011, A1. Location in patent: Page/Page column 32
[2] Patent: WO2008/86128, 2008, A2. Location in patent: Page/Page column 35
[3] Patent: WO2015/54358, 2015, A1. Location in patent: Page/Page column 106

4-chloropyrrolo[1,2-f][1,2,4]triazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloropyrrolo[1,2-f][1,2,4]triazine manufacturers

Career Henan Chemical Co

Product: 4-chloropyrrolo[1,2-f][1,2,4]triazine 888720-29-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 200kg
Release date: 2020-03-06

Career Henan Chemical Co

Product: 4-chloropyrrolo[1,2-f][1,2,4]triazine 888720-29-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 200kg
Release date: 2020-03-06

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