2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
- Product Name
- 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
- CAS No.
- 918538-05-3
- Chemical Name
- 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
- Synonyms
- 2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine;4-Dichloropyrrolo[1;2,4-Dichloro-pyrrolo[2,1-...;24-Dichloropyrrolo[2,1-/[1,2 4]triazine;2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine;Pyrrolo[2,1-f][1,2,4]triazine, 2,4-dichloro-
- CBNumber
- CB11504560
- Molecular Formula
- C6H3Cl2N3
- Formula Weight
- 188.01
- MOL File
- 918538-05-3.mol
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Property
- Density
- 1.69
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -5.36±0.30(Predicted)
- form
- solid
- color
- Yellow-green
- InChI
- InChI=1S/C6H3Cl2N3/c7-5-4-2-1-3-11(4)10-6(8)9-5/h1-3H
- InChIKey
- BSZGZNRUUJXKKQ-UHFFFAOYSA-N
- SMILES
- N12C=CC=C1C(Cl)=NC(Cl)=N2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- D482128
- Product name
- 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD148868
- Product name
- 2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine
- Packaging
- 25mg
- Price
- $82.5
- Updated
- 2021/12/16
- Product number
- 3H32-5-B5
- Product name
- 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD148868
- Product name
- 2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine
- Packaging
- 50mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FD148868
- Product name
- 2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine
- Packaging
- 100mg
- Price
- $195
- Updated
- 2021/12/16
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Chemical Properties,Usage,Production
Synthesis
918538-04-2
918538-05-3
The general procedure for the synthesis of 2,4-dichloropyrrolo[2,1-f][1,2,4]triazines using pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione as a starting material was as follows: to a solvent mixture containing diisopropylethylamine (4.5 mL) and toluene (20 mL) under nitrogen protection, intermediate 5 (1.6 g, 10.4 mmol) and phosphorous trichloride (2.94 mL). The reaction mixture was transferred to a sealed tube and the reaction was heated at 120 °C for 20 hours. After the reaction was completed, the mixture was slowly poured into ice-cooled saturated sodium bicarbonate solution (50 mL) and stirred for 15 minutes. The aqueous phase was extracted with dichloromethane (3 x 50 mL) and the organic layers were combined. The organic layer was washed once with saturated saline (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with gradient elution of hexane solution with 50-100% dichloromethane as eluent to afford the target product 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine as a light brown solid (1.2 g, 86% yield). The product was characterized by 1H NMR (CDCl3) and mass spectrometry: 1H NMR (CDCl3): δ 6.98 (1H, m), 7.05 (1H, m), 7.86 (1H, m); MS: 187 (M+).
References
[1] Patent: WO2017/219800, 2017, A1. Location in patent: Paragraph 0082; 0084
[2] Patent: US2007/4731, 2007, A1. Location in patent: Page/Page column 15
[3] Patent: US2008/9497, 2008, A1. Location in patent: Page/Page column 18
[4] Patent: WO2016/190847, 2016, A1. Location in patent: Paragraph 0343
[5] Patent: CN104974163, 2017, B. Location in patent: Paragraph 0522; 0523; 0524; 0525
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine manufacturers
- Product
- 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine 918538-05-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-25