4-chloropyrrolo[1,2-f][1,2,4]triazine
- Product Name
- 4-chloropyrrolo[1,2-f][1,2,4]triazine
- CAS No.
- 888720-29-4
- Chemical Name
- 4-chloropyrrolo[1,2-f][1,2,4]triazine
- Synonyms
- 4-chloropyrrolo[1;4-Chloropyrrolo[1,2-f][1,...;4-Chloropyrrolo[2,1-f][1,2,4]triazine;4-chloropyrrolo[1,2-f][1,2,4]triazine;Pyrrolo[2,1-f][1,2,4]triazine,4-chloro-
- CBNumber
- CB81856136
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 888720-29-4.mol
4-chloropyrrolo[1,2-f][1,2,4]triazine Property
- Density
- 1.51
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.85±0.30(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C380410
- Product name
- 4-Chloropyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC20381
- Product name
- 4-Chloropyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 3H32-5-C1
- Product name
- 4-Chloropyrrolo[1,2-f][1,2,4]triazine
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- FC20381
- Product name
- 4-Chloropyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 500mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- FC20381
- Product name
- 4-Chloropyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 1g
- Price
- $650
- Updated
- 2021/12/16
4-chloropyrrolo[1,2-f][1,2,4]triazine Chemical Properties,Usage,Production
Uses
4-Chloropyrrolo[1,2-f][1,2,4]triazine is a pyrrolotriazine derivative used in the preparation of kinase inhibitors for treating cancer.
Synthesis
159326-71-3
888720-29-4
General procedure for the synthesis of 4-chloropyrrolo[1,2-f][1,2,4]triazine from pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one: Step 3: Synthesis of 4-chloropyrrolo[1,2-f][1,2,4]triazine Diisopropylethylamine (3.5 mL, 20.3 mmol) was added to a solution of pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one (2.5 g, 18.5 mmol) dissolved in toluene (37.5 mL) under nitrogen protection. Subsequently, phosphorus trichloride (5.1 mL, 55.7 mmol) was added and the reaction mixture was heated at 100 °C for 20 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, aqueous sodium bicarbonate was added slowly and stirred at room temperature for 30 min. The aqueous layer was extracted with ethyl acetate and the organic phase was dried with magnesium sulfate and filtered. The filtrate was concentrated in vacuo to give a yellow solid product which could be used in the next reaction without further purification (2.31 g, 15.0 mmol, 81% yield). 1H NMR (400 MHz, CDCl3) δ: 8.22 (s, 1H), 7.87 (dd, J = 2.4 Hz, 1.6 Hz, 1H), 7.00-6.97 (m, 2H).
References
[1] Patent: US2011/183983, 2011, A1. Location in patent: Page/Page column 32
[2] Patent: WO2008/86128, 2008, A2. Location in patent: Page/Page column 35
[3] Patent: WO2015/54358, 2015, A1. Location in patent: Page/Page column 106
4-chloropyrrolo[1,2-f][1,2,4]triazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-chloropyrrolo[1,2-f][1,2,4]triazine manufacturers
- Product
- 4-chloropyrrolo[1,2-f][1,2,4]triazine 888720-29-4
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 200kg
- Release date
- 2020-03-06
- Product
- 4-chloropyrrolo[1,2-f][1,2,4]triazine 888720-29-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 200kg
- Release date
- 2020-03-06