ChemicalBook > CAS DataBase List > 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine

2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine

Product Name
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
CAS No.
918538-05-3
Chemical Name
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
Synonyms
2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine;4-Dichloropyrrolo[1;2,4-Dichloro-pyrrolo[2,1-...;24-Dichloropyrrolo[2,1-/[1,2 4]triazine;2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine;Pyrrolo[2,1-f][1,2,4]triazine, 2,4-dichloro-
CBNumber
CB11504560
Molecular Formula
C6H3Cl2N3
Formula Weight
188.01
MOL File
918538-05-3.mol
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2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Property

Density 
1.69
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-5.36±0.30(Predicted)
form 
solid
color 
Yellow-green
InChI
InChI=1S/C6H3Cl2N3/c7-5-4-2-1-3-11(4)10-6(8)9-5/h1-3H
InChIKey
BSZGZNRUUJXKKQ-UHFFFAOYSA-N
SMILES
N12C=CC=C1C(Cl)=NC(Cl)=N2
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
D482128
Product name
2,4-dichloropyrrolo[2,1-f][1,2,4]triazine
Packaging
1g
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD148868
Product name
2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine
Packaging
25mg
Price
$82.5
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-B5
Product name
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
Packaging
250mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD148868
Product name
2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine
Packaging
50mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD148868
Product name
2,4-Dichloropyrrolo[1,2-f][1,2,4]triazine
Packaging
100mg
Price
$195
Updated
2021/12/16
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2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Chemical Properties,Usage,Production

Synthesis

918538-04-2

918538-05-3

The general procedure for the synthesis of 2,4-dichloropyrrolo[2,1-f][1,2,4]triazines using pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione as a starting material was as follows: to a solvent mixture containing diisopropylethylamine (4.5 mL) and toluene (20 mL) under nitrogen protection, intermediate 5 (1.6 g, 10.4 mmol) and phosphorous trichloride (2.94 mL). The reaction mixture was transferred to a sealed tube and the reaction was heated at 120 °C for 20 hours. After the reaction was completed, the mixture was slowly poured into ice-cooled saturated sodium bicarbonate solution (50 mL) and stirred for 15 minutes. The aqueous phase was extracted with dichloromethane (3 x 50 mL) and the organic layers were combined. The organic layer was washed once with saturated saline (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with gradient elution of hexane solution with 50-100% dichloromethane as eluent to afford the target product 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine as a light brown solid (1.2 g, 86% yield). The product was characterized by 1H NMR (CDCl3) and mass spectrometry: 1H NMR (CDCl3): δ 6.98 (1H, m), 7.05 (1H, m), 7.86 (1H, m); MS: 187 (M+).

References

[1] Patent: WO2017/219800, 2017, A1. Location in patent: Paragraph 0082; 0084
[2] Patent: US2007/4731, 2007, A1. Location in patent: Page/Page column 15
[3] Patent: US2008/9497, 2008, A1. Location in patent: Page/Page column 18
[4] Patent: WO2016/190847, 2016, A1. Location in patent: Paragraph 0343
[5] Patent: CN104974163, 2017, B. Location in patent: Paragraph 0522; 0523; 0524; 0525

2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine Suppliers

China 132 Germany 1 India 3 United Kingdom 1 United States 13 Global 150
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine manufacturers

Career Henan Chemical Co
Product
2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine 918538-05-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-05-25

918538-05-3, 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazineRelated Search:

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