1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-
- CAS No.
- 943323-65-7
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-
- Synonyms
- 3-AMino-4-broMo-7-azaindole;4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine;4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-ylamine;1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-;4-bromo-1H-pyrrolo [2,3-B] pyridine-3-amine
- CBNumber
- CB81871748
- Molecular Formula
- C7H6BrN3
- Formula Weight
- 212.05
- MOL File
- 943323-65-7.mol
1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Property
- Density
- 1.867±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 13.63±0.40(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0050702
- Product name
- 3-AMINO-4-BROMO-7-AZAINDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.44
- Updated
- 2021/12/16
- Product number
- 943323657
- Product name
- 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
- Packaging
- 250mg
- Price
- $512.94
- Updated
- 2021/12/16
- Product number
- 61-2255
- Product name
- 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
- Purity
- 95%-98%
- Packaging
- 0.25g
- Price
- $612
- Updated
- 2021/12/16
- Product number
- 943323657
- Product name
- 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
- Packaging
- 1g
- Price
- $1221.08
- Updated
- 2021/12/16
- Product number
- BB20-3028
- Product name
- 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-ylamine
- Purity
- ＞95%
- Packaging
- 0.25G
- Price
- $225
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Chemical Properties,Usage,Production
Synthesis
943323-63-5
943323-65-7
4-Bromo-3-nitro-1H-pyrrolo[2,3-b]pyridine (500 mg, 2.07 mmol) was used as starting material, which was dissolved in 48% aqueous hydrobromic acid (4 mL) and heated at 70 °C. Subsequently, tin(II) chloride dihydrate (2.26 g, 10 mmol) was added in batches. After the addition was completed, the reaction was continued at 70 °C for 1 hour. Upon completion of the reaction, the mixture was cooled and carefully poured into a stirred ice-water mixture (15 mL). The pH of the reaction mixture was adjusted to 12 with sodium hydroxide solution and the insoluble material was separated by filtration. The filtrate was extracted with dichloromethane (3 x 100 mL), the organic phases were combined, washed sequentially with water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The target product 4-bromo-1H-pyrrolo[2,3-b]pyridin-3-amine (230 mg, 52.5% yield) was obtained, which could be used in the subsequent reaction without further purification.
References
[1] Patent: WO2013/114113, 2013, A1. Location in patent: Page/Page column 26
[2] Patent: US2015/11533, 2015, A1. Location in patent: Paragraph 0113
[3] Patent: WO2007/76423, 2007, A2. Location in patent: Page/Page column 154-155
1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Suppliers
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