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1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-

Product Name
1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-
CAS No.
943323-65-7
Chemical Name
1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-
Synonyms
3-AMino-4-broMo-7-azaindole;4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine;4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-ylamine;1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-;4-bromo-1H-pyrrolo [2,3-B] pyridine-3-amine
CBNumber
CB81871748
Molecular Formula
C7H6BrN3
Formula Weight
212.05
MOL File
943323-65-7.mol
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1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Property

Density 
1.867±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
13.63±0.40(Predicted)
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0050702
Product name
3-AMINO-4-BROMO-7-AZAINDOLE
Purity
95.00%
Packaging
5MG
Price
$497.44
Updated
2021/12/16
Alichem
Product number
943323657
Product name
4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
Packaging
250mg
Price
$512.94
Updated
2021/12/16
Abosyn
Product number
61-2255
Product name
4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
Purity
95%-98%
Packaging
0.25g
Price
$612
Updated
2021/12/16
Alichem
Product number
943323657
Product name
4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
Packaging
1g
Price
$1221.08
Updated
2021/12/16
Chemcia Scientific
Product number
BB20-3028
Product name
4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-ylamine
Purity
>95%
Packaging
0.25G
Price
$225
Updated
2021/12/16
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1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Chemical Properties,Usage,Production

Synthesis

943323-63-5

943323-65-7

4-Bromo-3-nitro-1H-pyrrolo[2,3-b]pyridine (500 mg, 2.07 mmol) was used as starting material, which was dissolved in 48% aqueous hydrobromic acid (4 mL) and heated at 70 °C. Subsequently, tin(II) chloride dihydrate (2.26 g, 10 mmol) was added in batches. After the addition was completed, the reaction was continued at 70 °C for 1 hour. Upon completion of the reaction, the mixture was cooled and carefully poured into a stirred ice-water mixture (15 mL). The pH of the reaction mixture was adjusted to 12 with sodium hydroxide solution and the insoluble material was separated by filtration. The filtrate was extracted with dichloromethane (3 x 100 mL), the organic phases were combined, washed sequentially with water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The target product 4-bromo-1H-pyrrolo[2,3-b]pyridin-3-amine (230 mg, 52.5% yield) was obtained, which could be used in the subsequent reaction without further purification.

References

[1] Patent: WO2013/114113, 2013, A1. Location in patent: Page/Page column 26
[2] Patent: US2015/11533, 2015, A1. Location in patent: Paragraph 0113
[3] Patent: WO2007/76423, 2007, A2. Location in patent: Page/Page column 154-155

1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo- Suppliers

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943323-65-7, 1H-Pyrrolo[2,3-b]pyridin-3-amine, 4-bromo-Related Search:


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  • 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine
  • 3-AMino-4-broMo-7-azaindole
  • 4-bromo-1H-pyrrolo [2,3-B] pyridine-3-amine
  • 943323-65-7