ChemicalBook > CAS DataBase List > 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

Product Name: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
CAS No.: 171178-45-3
Chemical Name: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
Synonyms: N-Boc-6-chloro-3-pyridinamine;3-(Boc-amino)-6-chloropyridine;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR;ert-butylN-(6-chloropyridin-3-yl)carbamate;tert-butyl N-(6-chloro-3-pyridyl)carbamate;5-tert-ButoxycarbonylaMino-2-chloropyridine;tert-butyl N-(6-chloropyridin-3-yl)carbamate;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE;1,1-Dimethylethyl N-(6-chloro-3-pyridinyl)carbamate;N-(6-chloro-3-pyridinyl)carbamic acid tert-butyl ester
CBNumber: CB8187518
Molecular Formula: C10H13ClN2O2
Formula Weight: 228.68
MOL File: 171178-45-3.mol

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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Property

Melting point:: 127-129°C
Boiling point:: 283.7±25.0 °C(Predicted)
Density: 1.245±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.06±0.70(Predicted)
Appearance: Light brown to light purple Solid
InChI: InChI=1S/C10H13ClN2O2/c1-10(2,3)15-9(14)13-7-4-5-8(11)12-6-7/h4-6H,1-3H3,(H,13,14)
InChIKey: IRHNQVINMHHEIO-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=CC=C(Cl)N=C1

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Safety

HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: T206183
Product name: tert-Butyl(6-Chloropyridin-3-yl)carbamate
Packaging: 10g
Price: $285
Updated: 2021/12/16

Oakwood

Product number: 024789
Product name: 5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine
Packaging: 1g
Price: $15
Updated: 2021/12/16

Oakwood

Product number: 024789
Product name: 5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine
Packaging: 5g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 058904
Product name: (6-Chloro-pyridin-3-yl)-carbamic acid tert-butylester
Purity: 95+%
Packaging: 1g
Price: $76
Updated: 2021/12/16

Apolloscientific

Product number: OR346263
Product name: (6-Chloro-pyridin-3-yl)-carbamicacidtert-butylester
Packaging: 1g
Price: $80
Updated: 2021/12/16

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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Chemical Properties,Usage,Production

Synthesis

5350-93-6

24424-99-5

171178-45-3

Step a: To a solution of dichloromethane (200 mL) containing 6-chloropyridin-3-amine (30.0 g, 0.23 mol), DMAP (1 g), and Et3N (41.7 g, 0.47 mol) was slowly added Boc2O (54.5 g, 0.25 mol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction mixture was washed with saturated NaHCO3 solution. The aqueous phase was extracted with dichloromethane and the combined organic phases were washed with brine (100 mL) and dried over anhydrous Na2SO4. Concentration of the organic phase under reduced pressure afforded tert-butyl 6-chloropyridin-3-ylcarbamate (50.0 g, 94% yield), the product was used directly for the next reaction without further purification.1H NMR (300 MHz, CDCl3) δ 8.23 (d, J=2.7 Hz, 1H), 7.97 (d, J=6.9 Hz, 1H), 7.27-7.24 (m, 1H), 6.58 (m, 1H), 7.25 (m, 1H), 6.25 (m, 1H), 6.25 (m, 1H). 1H), 6.58 (s, 1H), 1.52 (s, 9H).

References

[1] Inorganic Chemistry, 2017, vol. 56, # 14, p. 8381 - 8389
[2] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 9, p. 1233 - 1236
[3] Patent: US2002/22624, 2002, A1
[4] Patent: US2009/253736, 2009, A1. Location in patent: Page/Page column 24
[5] Patent: US2007/249615, 2007, A1. Location in patent: Page/Page column 29; 31; 34

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

5-Amino-2-chloropyridine Hexane Di-tert-butyl dicarbonate Triethylamine 1,4-Dioxane Dichloromethane PETROLEUM ETHER

Preparation Products

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View Lastest Price from 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE manufacturers

Honest Joy Holdings Limited

Product: tert-butyl N-(6-chloropyridin-3-yl)carbamate 171178-45-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.5%
Supply Ability: 100 tons
Release date: 2022-01-17

Dideu Industries Group Limited

Product: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 171178-45-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 171178-45-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 500kg/month
Release date: 2019-08-01

171178-45-3, 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINERelated Search:

N-Boc-3-bromo-4-fluoroaniline (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER tert-Butyl N-[5-bromo-2-chlorophenyl]carbamate N-BOC-2-FLUOROANILINE tert-Butyl N-(4-bromo-2,5-dimethylphenyl)carbamate (3-BroMo-4-Methyl-phenyl)-carbaMic acid tert-butyl ester ert-butyl N-(3-chlorophenyl)carbamate tert-butyl 4-bromo-3-chlorophenylcarbamate tert-butyl 2-bromo-5-methoxyphenylcarbamate tert-butyl 6-chloro-4-forMylpyridin-3-ylcarbaMate tert-Butyl (2-bromo-4-fluorophenyl)carbamate Carbamic acid, N-(2-bromo-4-methoxyphenyl)-, 1,1-dimethylethyl ester tert-butyl 3-bromo-5-methylphenylcarbamate (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester tert-butyl (2-bromo-5-chlorophenyl)carbamate Carbamic acid, (3,5-dibromophenyl)-, 1,1-dimethylethyl ester (9CI) N-Boc-2-bromo-3-methylphenylamine Carbamic acid, N-(3-bromo-4-methoxyphenyl)-, 1,1-dimethylethyl ester

5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine ,98%

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR

tert-butyl N-(6-chloropyridin-3-yl)carbamate

N-(6-chloro-3-pyridinyl)carbamic acid tert-butyl ester

(6-chloro-pyridin-3-yl)-carbamic acid, tert-butyl ester

5-tert-ButoxycarbonylaMino-2-chloropyridine

N-Boc-6-chloro-3-pyridinamine

Carbamic acid, N-(6-chloro-3-pyridinyl)-, 1,1-dimethylethyl ester

3-(Boc-amino)-6-chloropyridine

ert-butylN-(6-chloropyridin-3-yl)carbamate

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE ISO 9001：2015 REACH

1,1-Dimethylethyl N-(6-chloro-3-pyridinyl)carbamate

tert-butyl N-(6-chloro-3-pyridyl)carbamate

171178-45-3

API intermediates