ChemicalBook > CAS DataBase List > 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

Product Name
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
CAS No.
171178-45-3
Chemical Name
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
Synonyms
N-Boc-6-chloro-3-pyridinamine;3-(Boc-amino)-6-chloropyridine;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR;ert-butylN-(6-chloropyridin-3-yl)carbamate;tert-butyl N-(6-chloro-3-pyridyl)carbamate;5-tert-ButoxycarbonylaMino-2-chloropyridine;tert-butyl N-(6-chloropyridin-3-yl)carbamate;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE;1,1-Dimethylethyl N-(6-chloro-3-pyridinyl)carbamate;N-(6-chloro-3-pyridinyl)carbamic acid tert-butyl ester
CBNumber
CB8187518
Molecular Formula
C10H13ClN2O2
Formula Weight
228.68
MOL File
171178-45-3.mol
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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Property

Melting point:
127-129°C
Boiling point:
283.7±25.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
12.06±0.70(Predicted)
Appearance
Light brown to light purple Solid
InChI
InChI=1S/C10H13ClN2O2/c1-10(2,3)15-9(14)13-7-4-5-8(11)12-6-7/h4-6H,1-3H3,(H,13,14)
InChIKey
IRHNQVINMHHEIO-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1=CC=C(Cl)N=C1
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Safety

HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
T206183
Product name
tert-Butyl(6-Chloropyridin-3-yl)carbamate
Packaging
10g
Price
$285
Updated
2021/12/16
Oakwood
Product number
024789
Product name
5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine
Packaging
25g
Price
$150
Updated
2021/12/16
Oakwood
Product number
024789
Product name
5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine
Packaging
100g
Price
$450
Updated
2021/12/16
AK Scientific
Product number
J96741
Product name
tert-Butyl6-chloropyridin-3-ylcarbamate
Packaging
100g
Price
$465
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024302
Product name
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
Purity
95.00%
Packaging
1G
Price
$660.66
Updated
2021/12/16
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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Chemical Properties,Usage,Production

Synthesis

5350-93-6

24424-99-5

171178-45-3

Step a: To a solution of dichloromethane (200 mL) containing 6-chloropyridin-3-amine (30.0 g, 0.23 mol), DMAP (1 g), and Et3N (41.7 g, 0.47 mol) was slowly added Boc2O (54.5 g, 0.25 mol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction mixture was washed with saturated NaHCO3 solution. The aqueous phase was extracted with dichloromethane and the combined organic phases were washed with brine (100 mL) and dried over anhydrous Na2SO4. Concentration of the organic phase under reduced pressure afforded tert-butyl 6-chloropyridin-3-ylcarbamate (50.0 g, 94% yield), the product was used directly for the next reaction without further purification.1H NMR (300 MHz, CDCl3) δ 8.23 (d, J=2.7 Hz, 1H), 7.97 (d, J=6.9 Hz, 1H), 7.27-7.24 (m, 1H), 6.58 (m, 1H), 7.25 (m, 1H), 6.25 (m, 1H), 6.25 (m, 1H). 1H), 6.58 (s, 1H), 1.52 (s, 9H).

References

[1] Inorganic Chemistry, 2017, vol. 56, # 14, p. 8381 - 8389
[2] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 9, p. 1233 - 1236
[3] Patent: US2002/22624, 2002, A1
[4] Patent: US2009/253736, 2009, A1. Location in patent: Page/Page column 24
[5] Patent: US2007/249615, 2007, A1. Location in patent: Page/Page column 29; 31; 34

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

5-Amino-2-chloropyridine Hexane Di-tert-butyl dicarbonate Triethylamine 1,4-Dioxane Dichloromethane PETROLEUM ETHER

Preparation Products

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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Suppliers

China 136 India 1 United Kingdom 5 United States 13 Global 155
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE manufacturers

Honest Joy Holdings Limited
Product
tert-butyl N-(6-chloropyridin-3-yl)carbamate 171178-45-3
Price
US $0.00/KG
Min. Order
1KG
Purity
97.5%
Supply Ability
100 tons
Release date
2022-01-17
Dideu Industries Group Limited
Product
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 171178-45-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03
Career Henan Chemical Co
Product
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 171178-45-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

171178-45-3, 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINERelated Search:

N-Boc-3-bromo-4-fluoroaniline (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER tert-Butyl N-[5-bromo-2-chlorophenyl]carbamate N-BOC-2-FLUOROANILINE tert-Butyl N-(4-bromo-2,5-dimethylphenyl)carbamate (3-BroMo-4-Methyl-phenyl)-carbaMic acid tert-butyl ester ert-butyl N-(3-chlorophenyl)carbamate tert-butyl 4-bromo-3-chlorophenylcarbamate tert-butyl 2-bromo-5-methoxyphenylcarbamate tert-butyl 6-chloro-4-forMylpyridin-3-ylcarbaMate tert-Butyl (2-bromo-4-fluorophenyl)carbamate Carbamic acid, N-(2-bromo-4-methoxyphenyl)-, 1,1-dimethylethyl ester tert-butyl 3-bromo-5-methylphenylcarbamate (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester tert-butyl (2-bromo-5-chlorophenyl)carbamate Carbamic acid, (3,5-dibromophenyl)-, 1,1-dimethylethyl ester (9CI) N-Boc-2-bromo-3-methylphenylamine Carbamic acid, N-(3-bromo-4-methoxyphenyl)-, 1,1-dimethylethyl ester

  • 5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine ,98%
  • 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
  • 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR
  • tert-butyl N-(6-chloropyridin-3-yl)carbamate
  • N-(6-chloro-3-pyridinyl)carbamic acid tert-butyl ester
  • (6-chloro-pyridin-3-yl)-carbamic acid, tert-butyl ester
  • 5-tert-ButoxycarbonylaMino-2-chloropyridine
  • N-Boc-6-chloro-3-pyridinamine
  • Carbamic acid, N-(6-chloro-3-pyridinyl)-, 1,1-dimethylethyl ester
  • 3-(Boc-amino)-6-chloropyridine
  • ert-butylN-(6-chloropyridin-3-yl)carbamate
  • 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE ISO 9001：2015 REACH
  • 1,1-Dimethylethyl N-(6-chloro-3-pyridinyl)carbamate
  • tert-butyl N-(6-chloro-3-pyridyl)carbamate
  • 171178-45-3
  • API intermediates