1-(2-Hydroxyethyl)-4-methylpiperazine
- Product Name
- 1-(2-Hydroxyethyl)-4-methylpiperazine
- CAS No.
- 5464-12-0
- Chemical Name
- 1-(2-Hydroxyethyl)-4-methylpiperazine
- Synonyms
- 4-Methylpiperazine-1-ethanol;4-Methyl-1-piperazineethanol;1-[N-Methylpiperazine]ethanol;2-(4-methylpiperazinyl)ethanol;1-piperazineethanol, 4-methyl-;4-Methylpiperazine-1-ethanol>2-(4-Methyl-1-piperazinyl)ethanol;2-(4-METHYLPIPERAZIN-1-YL)ETHANOL;1-hydroxyethyl-4-methylpiperazine;1-(2-Hydroxyethyl)-4-methyl-piper
- CBNumber
- CB8187583
- Molecular Formula
- C7H16N2O
- Formula Weight
- 144.21
- MOL File
- 5464-12-0.mol
1-(2-Hydroxyethyl)-4-methylpiperazine Property
- Melting point:
- 39-41°C
- Boiling point:
- 54-55°C/0.5mbar
- Density
- 1.003±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 14.96±0.10(Predicted)
- form
- Low Melting Solid
- color
- Slightly yellow
- InChI
- InChI=1S/C7H16N2O/c1-8-2-4-9(5-3-8)6-7-10/h10H,2-7H2,1H3
- InChIKey
- QHTUMQYGZQYEOZ-UHFFFAOYSA-N
- SMILES
- N1(CCO)CCN(C)CC1
- CAS DataBase Reference
- 5464-12-0(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36/37/39-24/25-23
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2499
- Product name
- 4-Methylpiperazine-1-ethanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- M2499
- Product name
- 4-Methylpiperazine-1-ethanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $117
- Updated
- 2025/07/31
- Product number
- H949523
- Product name
- 1-(2-Hydroxyethyl)-4-methylpiperazine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- H949523
- Product name
- 1-(2-Hydroxyethyl)-4-methylpiperazine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR0879
- Product name
- 1-(2-Hydroxyethyl)-4-methylpiperazine
- Purity
- 95%
- Packaging
- 25g
- Price
- $45
- Updated
- 2021/12/16
1-(2-Hydroxyethyl)-4-methylpiperazine Chemical Properties,Usage,Production
Chemical Properties
slightly yellow low melting solid
Synthesis
109-01-3
540-51-2
5464-12-0
The general procedure for the synthesis of 1-(2-hydroxyethyl)-4-methylpiperazine from N-methylpiperazine and 2-bromoethanol was as follows: 2-bromoethanol (2.36 g, 19 mmol) was added slowly and dropwise to a reaction flask containing a mixture of anhydrous ethanol (150 μL) with 1-methylpiperazine (1.26 g, 13 mmol) and potassium carbonate (5.0 g, 36 mmol). The reaction mixture was heated under reflux conditions for 18 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature and filtered to remove the insoluble precipitate. Subsequently, the solvent was removed by rotary evaporation. The residue was treated with a solvent mixture of acetone/dichloromethane (v/v ratio not specified), filtered again to remove the insoluble material, and finally the solvent was removed by rotary evaporation to afford 1-(2-hydroxyethyl)-4-methylpiperazine (870 mg, 48% yield) as a light brown oil. The product was confirmed by 1H NMR (CDCl3): δ 2.18 (s, 3H); 2.3-2.7 (br m, 8H); 2.56 (t, 2H); 3.61 (t, 2H).MS-ESI showed a molecular ion peak of 145 [MH]+.
References
[1] Patent: WO2004/7498, 2004, A2. Location in patent: Page 29
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 7, p. 622 - 626
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6305 - 6320
[4] Patent: US6291455, 2001, B1
[5] Patent: US2003/225111, 2003, A1. Location in patent: Page 41
1-(2-Hydroxyethyl)-4-methylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-Hydroxyethyl)-4-methylpiperazine Suppliers
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- info@matrix-marketing.ch
- Country
- Switzerland
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View Lastest Price from 1-(2-Hydroxyethyl)-4-methylpiperazine manufacturers
- Product
- 1-(2-Hydroxyethyl)-4-methylpiperazine 5464-12-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-(2-Hydroxyethyl)-4-methylpiperazine 5464-12-0
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07