ChemicalBook > CAS DataBase List > 5-Hydroxymethylthiophene-2-boronic acid
5-Hydroxymethylthiophene-2-boronic acid
- Product Name
- 5-Hydroxymethylthiophene-2-boronic acid
- CAS No.
- 338454-45-8
- Chemical Name
- 5-Hydroxymethylthiophene-2-boronic acid
- Synonyms
- 5-HYDROXYMETHYLTHIOPHENE-2-BORONIC ACID;5-(hydroxymethyl)thiophen-2-yl]boronicaci;5-(Hydroxymethyl)thiophene-2-boronic aicd;[5-(hydroxyMethyl)thiophen-2-yl]boronic acid;5-(hydroxymethyl)thiophen-2-yl-2-boronic acid;5-Hydroxymethylthiophene-2-boronic acid, >=98%;Boronic acid, B-[5-(hydroxymethyl)-2-thienyl]-;(5-(Hydroxymethyl)thiophen-2-yl)boronic acid(contains varying amounts of Anhydride)
- CBNumber
- CB8190815
- Molecular Formula
- C5H7BO3S
- Formula Weight
- 157.98
- MOL File
- 338454-45-8.mol
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5-Hydroxymethylthiophene-2-boronic acid Property
- Boiling point:
- 399.9±52.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 8.42±0.53(Predicted)
- Appearance
- White to light yellow Solid
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Safety
- HS Code
- 2934999090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- H973045
- Product name
- 5-Hydroxymethylthiophene-2-boronicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
TRC
- Product number
- H973045
- Product name
- 5-Hydroxymethylthiophene-2-boronicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 093054
- Product name
- 5-Hydroxymethylthiophene-2-boronic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $364
- Updated
- 2021/12/16
AK Scientific
- Product number
- N212
- Product name
- 5-Hydroxymethylthiophene-2-boronicacid
- Packaging
- 100mg
- Price
- $74
- Updated
- 2021/12/16
AK Scientific
- Product number
- N212
- Product name
- 5-Hydroxymethylthiophene-2-boronicacid
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
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5-Hydroxymethylthiophene-2-boronic acid Chemical Properties,Usage,Production
Synthesis
636-72-6
338454-45-8
General procedure for the synthesis of 5-hydroxymethylthiophene-2-boronic acid from 2-thiophene methanol: 2-hydroxymethylthiophene (2.28 g, 20 mmol) was dissolved in molecularly sieve-dried tetrahydrofuran (40 mL), the solution was cooled to -78 °C, and a 1.6 M n-butyllithium solution (25 mL, 40 mmol) in n-hexane was added slowly and dropwise, protected by argon gas. Subsequently, the reaction mixture was warmed to -30 °C and then cooled again to -78 °C and a solution of tetrahydrofuran (20 mL) of trimethyl borate (6.69 mL, 60 mmol) was added dropwise at this temperature. The reaction was held between -78 °C and -70 °C for 15 minutes. After continuing to stir at -78 °C for 2 h, the mixture was slowly warmed to room temperature and poured into water (50 mL) and the pH was adjusted to 3. 2 N aqueous hydrochloric acid (28 mL) was added and the mixture was extracted with ether, the extract was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, filtered, and concentrated. The product 5-hydroxymethylthiophene-2-boronic acid 1.1 g (yield 36%) was obtained as a brown oil. Mass spectrum (MS): 158 (M).
References
[1] Patent: US6821980, 2004, B1. Location in patent: Page column 30-31
5-Hydroxymethylthiophene-2-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Hydroxymethylthiophene-2-boronic acid manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 5-Hydroxymethylthiophene-2-boronic acid 338454-45-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 5-Hydroxymethylthiophene-2-boronic acid 338454-45-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 5-Hydroxymethylthiophene-2-boronic acid 338454-45-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
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