ChemicalBook > CAS DataBase List > BOC-D-TIC-OH

BOC-D-TIC-OH

Uses

Product Name: BOC-D-TIC-OH
CAS No.: 115962-35-1
Chemical Name: BOC-D-TIC-OH
Synonyms: BOC-D-TIC;BOC-(3R)-1;(R)-N-BOC-1;BOC-D-TIC-OH;Boc-D-Tic-Ooh;RARECHEM BK PT 0080;Boc-D-Tic-OH;BOC-D-TIC-OH USP/EP/BP;N-t-Butyloxycarbonyl-D-1;(Tert-Butoxy)Carbonyl D-Tic-OH
CBNumber: CB8191993
Molecular Formula: C15H19NO4
Formula Weight: 277.32
MOL File: 115962-35-1.mol

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BOC-D-TIC-OH Property

Melting point:: 122-123℃
Boiling point:: 420.18°C (rough estimate)
Density: 1.1311 (rough estimate)
refractive index: 1.5080 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.88±0.20(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 115962-35-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15046
Product name: Boc-D-Tic-OH
Purity: ≥97%
Packaging: 1g
Price: $200
Updated: 2021/12/16

TRC

Product number: B658953
Product name: BOC-D-TIC-OH
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J94578
Product name: Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid
Packaging: 1g
Price: $15
Updated: 2021/12/16

Chem-Impex

Product number: 02600
Product name: Boc-(3)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Purity: ≥ 98% (HPLC)
Packaging: 1G
Price: $15
Updated: 2021/12/16

Matrix Scientific

Product number: 041824
Product name: Boc-(R)-1,2,3,4-tetrahydroisoquino-line-3-carboxylic acid
Packaging: 1g
Price: $37
Updated: 2021/12/16

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BOC-D-TIC-OH Chemical Properties,Usage,Production

Uses

BOC-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid can be used as an organic synthesis intermediate. It can be obtained by protecting (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride with Boc, or by reacting L-Phe with aqueous formaldehyde solution and tert-butoxyanhydride.

Chemical Properties

white to light beige powder

Synthesis

24424-99-5

74163-81-8

115962-35-1

The general procedure for the synthesis of (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid from di-tert-butyl dicarbonate and (S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was as follows: (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (50.0 g, 282 mmol) was suspended in 1,4-dioxane ( 1000 mL) and water (500 mL) in a solvent mixture with vigorous stirring. Subsequently, sodium bicarbonate (47.4 g, 564 mmol) and di-tert-butyl dicarbonate (67.7 g, 310 mmol) were added and the reaction mixture was stirred continuously at room temperature for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in water (2000 mL) and acidified by adding 30% w/v aqueous sodium bisulfate monohydrate (300 mL). The acidified aqueous phase was extracted with chloroform (3 x 1000 mL) and the organic phases were combined. The organic phases were sequentially washed with saturated saline, dried over anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to afford the target product (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (90.0 g, quantitative yield) as a thick slurry. The product was confirmed by LCMS analysis: retention time (RT) 3.64 min; mass spectral data: m/z 178.1 [M-Boc + 2H]+; m/z 276.1 [M-H]-.

References

[1] Patent: WO2017/153513, 2017, A1. Location in patent: Page/Page column 78
[2] Patent: WO2017/153515, 2017, A1. Location in patent: Page/Page column 62
[3] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 44; 47
[4] Patent: WO2017/153519, 2017, A1. Location in patent: Page/Page column 56; 59
[5] Tetrahedron Letters, 2001, vol. 42, # 43, p. 7559 - 7561

BOC-D-TIC-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-TIC-OH Suppliers

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View Lastest Price from BOC-D-TIC-OH manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: BOC-D-TIC-OH 115962-35-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Career Henan Chemical Co

Product: BOC-D-TIC-OH 115962-35-1
Price: US $1.00/g
Min. Order: 100g
Purity: >98%
Supply Ability: g/kg/Ton
Release date: 2020-01-14

115962-35-1, BOC-D-TIC-OHRelated Search:

H-TIC-OH D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid BOC-L-TIC-OH BOC-D-TIC(OH)-OH,Boc-D-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Boc-7-hydroxy-D-Tic-OH Boc-D-Tic(OH)-OH) BOC-HYDROXY-TIC-OH,BOC-L-TIC(OH)-OH BOC-D-TIC-OH

BOC-D-TIC

BOC-D-TIC-OH

BOC-D-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

N-t-Butyloxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid

(R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected

N-Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli

N-Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli acid

Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic

Boc-D-Tic-OH(Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid)

(3R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

N-BOC-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid,99%

Boc-<SC>D</SC>-Tic-OH

(R)-N-BOC-1

BOC-(3R)-1

N-t-Butyloxycarbonyl-D-1

2-BOC-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Boc-D-Tic-Ooh

N-ALPHA-T-BOC-D-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID

N-ALPHA-T-BUTOXYCARBONYL-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

N-BOC-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

N-TERT-BUTYLOXYCARBONYL-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

N-1-BOC-D-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID

N-1-T-BOC-D-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID

RARECHEM BK PT 0080

(R)-(-)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID

(R)-(-)-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID

(R)-N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

2,3(1H)-ISOQUINOLINEDICARBOXYLIC ACID, 3,4-DIHYDRO-,2-(1,1-DIMETHYLETHYL) ESTER, (3R)-

(3R)-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID

BOC-(R)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

BOC-1,2,3,4-D-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

BOC-(3R)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

BOC-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

(Tert-Butoxy)Carbonyl D-Tic-OH

(3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected

Boc-(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid≥ 98% (HPLC)

(R)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic A cid,99%e.e.

Boc-(R)-1,2,3,4-tetrahydroisoquino-line-3-carboxylicaci

BOC-D-TIC-OH USP/EP/BP

(3R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

115962-35-1

C15HNO4

Unnatural Amino Acid Derivatives

Others

Peptide Synthesis

Specialty Synthesis

a-amino

API intermediates

Amino Acids