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BOC-D-TIC-OH

Uses
Product Name
BOC-D-TIC-OH
CAS No.
115962-35-1
Chemical Name
BOC-D-TIC-OH
Synonyms
BOC-D-TIC;BOC-(3R)-1;(R)-N-BOC-1;BOC-D-TIC-OH;Boc-D-Tic-Ooh;RARECHEM BK PT 0080;Boc-D-Tic-OH;BOC-D-TIC-OH USP/EP/BP;N-t-Butyloxycarbonyl-D-1;(Tert-Butoxy)Carbonyl D-Tic-OH
CBNumber
CB8191993
Molecular Formula
C15H19NO4
Formula Weight
277.32
MOL File
115962-35-1.mol
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BOC-D-TIC-OH Property

Melting point:
122-123℃
Boiling point:
420.18°C (rough estimate)
Density 
1.1311 (rough estimate)
refractive index 
1.5080 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
3.88±0.20(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
115962-35-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15046
Product name
Boc-D-Tic-OH
Purity
≥97%
Packaging
1g
Price
$200
Updated
2021/12/16
TRC
Product number
B658953
Product name
BOC-D-TIC-OH
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J94578
Product name
Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid
Packaging
1g
Price
$15
Updated
2021/12/16
Chem-Impex
Product number
02600
Product name
Boc-(3)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Purity
≥ 98% (HPLC)
Packaging
1G
Price
$15
Updated
2021/12/16
Matrix Scientific
Product number
041824
Product name
Boc-(R)-1,2,3,4-tetrahydroisoquino-line-3-carboxylic acid
Packaging
1g
Price
$37
Updated
2021/12/16
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BOC-D-TIC-OH Chemical Properties,Usage,Production

Uses

BOC-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid can be used as an organic synthesis intermediate. It can be obtained by protecting (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride with Boc, or by reacting L-Phe with aqueous formaldehyde solution and tert-butoxyanhydride.

Chemical Properties

white to light beige powder

Synthesis

24424-99-5

74163-81-8

115962-35-1

The general procedure for the synthesis of (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid from di-tert-butyl dicarbonate and (S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was as follows: (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (50.0 g, 282 mmol) was suspended in 1,4-dioxane ( 1000 mL) and water (500 mL) in a solvent mixture with vigorous stirring. Subsequently, sodium bicarbonate (47.4 g, 564 mmol) and di-tert-butyl dicarbonate (67.7 g, 310 mmol) were added and the reaction mixture was stirred continuously at room temperature for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in water (2000 mL) and acidified by adding 30% w/v aqueous sodium bisulfate monohydrate (300 mL). The acidified aqueous phase was extracted with chloroform (3 x 1000 mL) and the organic phases were combined. The organic phases were sequentially washed with saturated saline, dried over anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to afford the target product (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (90.0 g, quantitative yield) as a thick slurry. The product was confirmed by LCMS analysis: retention time (RT) 3.64 min; mass spectral data: m/z 178.1 [M-Boc + 2H]+; m/z 276.1 [M-H]-.

References

[1] Patent: WO2017/153513, 2017, A1. Location in patent: Page/Page column 78
[2] Patent: WO2017/153515, 2017, A1. Location in patent: Page/Page column 62
[3] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 44; 47
[4] Patent: WO2017/153519, 2017, A1. Location in patent: Page/Page column 56; 59
[5] Tetrahedron Letters, 2001, vol. 42, # 43, p. 7559 - 7561

BOC-D-TIC-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-TIC-OH Suppliers

Belgium 1 China 119 Europe 2 France 2 Germany 5 India 3 Japan 3 South Korea 1 Switzerland 2 United Kingdom 8 United States 34 Global 180
chemcube
Tel
--
Fax
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Email
sales@chemcube.eu
Country
Germany
ProdList
4083
Advantage
34
IRIS Biotech GmbH
Tel
--
Fax
--
Country
Germany
ProdList
4426
Advantage
68
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
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Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Rare Chemicals GmbH
Tel
--
Fax
--
Email
sales@rarechem.de
Country
Germany
ProdList
6297
Advantage
38
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View Lastest Price from BOC-D-TIC-OH manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
BOC-D-TIC-OH 115962-35-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
Career Henan Chemical Co
Product
BOC-D-TIC-OH 115962-35-1
Price
US $1.00/g
Min. Order
100g
Purity
>98%
Supply Ability
g/kg/Ton
Release date
2020-01-14

115962-35-1, BOC-D-TIC-OHRelated Search:

H-TIC-OH D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid BOC-L-TIC-OH BOC-D-TIC(OH)-OH,Boc-D-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Boc-7-hydroxy-D-Tic-OH Boc-D-Tic(OH)-OH) BOC-HYDROXY-TIC-OH,BOC-L-TIC(OH)-OH BOC-D-TIC-OH

  • BOC-D-TIC
  • BOC-D-TIC-OH
  • BOC-D-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-t-Butyloxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid
  • (R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected
  • N-Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli
  • N-Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli acid
  • Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic
  • Boc-D-Tic-OH(Boc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid)
  • (3R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
  • N-BOC-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid,99%
  • Boc-<SC>D</SC>-Tic-OH
  • (R)-N-BOC-1
  • BOC-(3R)-1
  • N-t-Butyloxycarbonyl-D-1
  • 2-BOC-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • Boc-D-Tic-Ooh
  • N-ALPHA-T-BOC-D-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • N-ALPHA-T-BUTOXYCARBONYL-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-BOC-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-TERT-BUTYLOXYCARBONYL-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-1-BOC-D-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • N-1-T-BOC-D-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • RARECHEM BK PT 0080
  • (R)-(-)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
  • (R)-(-)-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
  • (R)-N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • 2,3(1H)-ISOQUINOLINEDICARBOXYLIC ACID, 3,4-DIHYDRO-,2-(1,1-DIMETHYLETHYL) ESTER, (3R)-
  • (3R)-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-(R)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-1,2,3,4-D-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-(3R)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • (Tert-Butoxy)Carbonyl D-Tic-OH
  • (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected
  • Boc-(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid≥ 98% (HPLC)
  • (R)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic A cid,99%e.e.
  • Boc-(R)-1,2,3,4-tetrahydroisoquino-line-3-carboxylicaci
  • BOC-D-TIC-OH USP/EP/BP
  • (3R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • 115962-35-1
  • C15HNO4
  • Unnatural Amino Acid Derivatives
  • Others
  • Peptide Synthesis
  • Specialty Synthesis
  • a-amino
  • API intermediates
  • Amino Acids