4-Perhydroazepinone hydrochloride
- Product Name
- 4-Perhydroazepinone hydrochloride
- CAS No.
- 50492-22-3
- Chemical Name
- 4-Perhydroazepinone hydrochloride
- Synonyms
- 4-PerhydroazepinoneHCl;Azelastine Impurity 19;4-AZEPANONE HYDROCHLORIDE;4-Perhydroazepinone hydro;4-Azepanonehydrochloride,96%;HEXAHYDRO-4H-AZEPIN-4-ONE HCL;Azepan-4-one hydrochloride (1:1);4-PERHYDROAZEPINONE HYDROCHLORIDE;PERHYDROAZEPIN-4-ONEHYDROCHLORIDE;4-Oxohomopiperidine hydrochloride
- CBNumber
- CB8202235
- Molecular Formula
- C6H12ClNO
- Formula Weight
- 149.62
- MOL File
- 50492-22-3.mol
4-Perhydroazepinone hydrochloride Property
- Melting point:
- 176-181℃
- Flash point:
- 152°(306°F)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in DMSO, Ethanol, Methanol
- form
- Solid
- color
- White to Orange to Green
- InChI
- InChI=1S/C6H11NO.ClH/c8-6-2-1-4-7-5-3-6;/h7H,1-5H2;1H
- InChIKey
- WFTRLIZPJMFJER-UHFFFAOYSA-N
- SMILES
- C1(=O)CCNCCC1.Cl
- CAS DataBase Reference
- 50492-22-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-20/22
- Safety Statements
- 26-36/37/39-36/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2914290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 737402
- Product name
- Hexahydro-4-azepinone hydrochloride
- Purity
- 96%
- Packaging
- 1g
- Price
- $24.35
- Updated
- 2025/07/31
- Product number
- H1673
- Product name
- Hexahydro-4-azepinone Hydrochloride
- Packaging
- 1G
- Price
- $25
- Updated
- 2025/07/31
- Product number
- H1673
- Product name
- Hexahydro-4-azepinone Hydrochloride
- Packaging
- 5G
- Price
- $97
- Updated
- 2025/07/31
- Product number
- A809755
- Product name
- Azepan-4-oneHydrochloride
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA18073
- Product name
- Azepan-4-one hydrochloride
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
4-Perhydroazepinone hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
4-Azepanone hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthesis
623-73-4
29976-53-2
50492-22-3
Step 1: Synthesis of azepan-4-one hydrochloride (intermediate): To a stirred solution of N-ethoxycarbonyl-4-piperidone (600 mg, 3.00 mmol) in anhydrous ether (1.5 mL) under nitrogen protection was added simultaneously a solution of boron trifluoride in ethyl ether (380 μL, 3.00 mmol) and ethyl diazoacetate (412 μL, 3.92 mmol) each dissolved in anhydrous ether (0.4 mL) to a solution at a reaction temperature of -35 °C. The reaction mixture was stirred continuously at -35 °C for 1 h 30 min, followed by slow warming to room temperature. After completion of the reaction, the reaction solution was washed with 30% aqueous potassium carbonate (3 mL) and the organic phase was extracted with ethyl acetate (3 x 5 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was dissolved in 4N aqueous hydrochloric acid (13 mL) and refluxed for 6 hours. At the end of the reaction, the solvent was removed under reduced pressure to give a light yellow oil (400 mg, 88% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.04 (m, 4H, CH2NH), 2.59 (m, 4H, CH2CO), 1.86 (m, 1H, NH), 1.75 (m, 2H, CH2CH2NH).
References
[1] Patent: EP1997381, 2008, A1. Location in patent: Page/Page column 16
[2] Patent: EP1997805, 2008, A1. Location in patent: Page/Page column 23
4-Perhydroazepinone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Perhydroazepinone hydrochloride manufacturers
- Product
- 4-Perhydroazepinone hydrochloride 50492-22-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 4-Perhydroazepinone hydrochloride 50492-22-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09