Penfluridol

ChemicalBook > CAS DataBase List > Penfluridol

Product Name: Penfluridol
CAS No.: 26864-56-2
Chemical Name: Penfluridol
Synonyms: Semap;R16341;TLP-607;Penfuridol;Penfluidol;PENFLURIDOL;PHENFLURIDOL;McN-JR-16,341;Penfluridol>Penfluridol, >=98%
CBNumber: CB8205397
Molecular Formula: C28H27ClF5NO
Formula Weight: 523.97
MOL File: 26864-56-2.mol

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Penfluridol Property

Melting point:: 105-107°C
Boiling point:: 587.7±50.0 °C(Predicted)
Density: 1.2425 (estimate)
storage temp.: 2-8°C
solubility: H₂O: insoluble
form: powder
pka: 13.49±0.20(Predicted)
color: white
Merck: 14,7087
CAS DataBase Reference: 26864-56-2(CAS DataBase Reference)
NIST Chemistry Reference: Penfluridol(26864-56-2)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TN6957000
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990
Toxicity: LD50 orally in mice (day 7): 86.8 mg/kg (Janssen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P3371
Product name: Penfluridol
Purity: ≥97% (HPLC), powder
Packaging: 50mg
Price: $175
Updated: 2024/03/01

TCI Chemical

Product number: P2076
Product name: Penfluridol
Purity: >98.0%(T)
Packaging: 1g
Price: $49
Updated: 2024/03/01

TCI Chemical

Product number: P2076
Product name: Penfluridol
Purity: >98.0%(T)
Packaging: 200mg
Price: $16
Updated: 2024/03/01

Cayman Chemical

Product number: 26071
Product name: Penfluridol
Purity: ≥98%
Packaging: 100mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 26071
Product name: Penfluridol
Purity: ≥98%
Packaging: 250mg
Price: $81
Updated: 2024/03/01

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Penfluridol Chemical Properties,Usage,Production

Originator

Semap,Janssen-Le Brun ,W. Germany ,1975

Uses

In terms of pharmacological action, penfluridol is similar to pimozide; however, it is significantly longer lasting, which is connected to the slow metabolism of the drug. Penfluridol is used as a supportive therapy in ambulatory settings for patients suffering from schizophrenia as well as patients with paranoid, psychotic, and neuroleptic conditions.

Uses

Penfluridol has been used as an antipsychotic agent:

to study its antimetastatic effect on triple-negative breast cancer cells
to study its effects on the growth of glioblastoma cell lines,
to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Uses

antineoplastic

Definition

ChEBI: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol is a diarylmethane.

Manufacturing Process

A mixture of 24 parts of 4,4-bis(p-fluorophenyl)butyl chloride, 20.9 parts of 4(4-chloro-α,α,α-trifluoro-m-tolyl)-4-piperidinol, 13.8 parts of sodium carbonate, a few crystals of potassium iodide in 600 parts of 4-methyl-2pentanone is stirred and refluxed for 60 hours. The reaction mixture is cooled and 150 parts of water is added. The organic layer is separated, dried, filtered and evaporated. The oily residue is crystallized from diisopropylether, yielding 4-(4chloro-α,α,α-trifluoro-m-tolyl)-1-[4,4-bis(p-fiuorophenyl)butyl]-4piperidinol; melting point 106.5°C.

brand name

Semap (Ortho-McNeil).

Therapeutic Function

Antipsychotic

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.

Safety Profile

Poison by ingestion and intravenous routes. Experimental teratogenic and reproductive effects. A neuroleptic agent. When heated to decomposition it emits very toxic fumes of Cl-, F-, and NOx.

Synthesis

Penfluridol, 4-(4-chloro-3-trifluoromethylphenyl)-1-[4,4-bis-(p-fluorophenyl) butyl]-4-piperidinol (6.6.12), is synthesized implementing a Grignard reaction between 1-carbomethoxypiperidin-4-one and 4-chloro-3-trifluoromethylphenylmagnesium bromide, giving 1-carbomethoxy-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol (6.6.10). Upon alkaline hydrolysis of the carbomethoxy group, it turns into (4-chloro-3-trifluoromethylphenyl)-4-piperidinol (6.6.11), the alkylation of which with 1,1-bis(4-fluorophenyl)butyl bromide (6.6.3) gives penfluridol (6.6.12) [67¨C69].

Penfluridol Preparation Products And Raw materials

Raw materials

Fluorobenzene

Preparation Products

N-Carbethoxy-4-piperidone

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View Lastest Price from Penfluridol manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Penfluridol 26864-56-2
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2023-07-21

Weijer International Trade (Hebei) Co., Ltd

Product: Penfluridol 26864-56-2
Price: US $80.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-22

Shanxi Naipu Import and Export Co.,Ltd

Product: Penfluridol 26864-56-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500tons/month
Release date: 2021-09-08

26864-56-2, Penfluridol Related Search:

Butyl acrylate Butyl acetate tert-Butylchlorodiphenylsilane DROPERIDOL 2,2,6,6-Tetramethyl-4-piperidinol Buprofezin 2-Butoxyethanol Phenylhydrazine PHENYL VALERATE Triacetonediamine Epichlorohydrin Haloperidol Difluorochloromethane 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL 4-(3-Trifuoromethyl)phenyl-4-piperidinol

1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol

1-[4,4-Bis(p-flurophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol

4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-

Penfluridol, >=98%

1-[4,4-BIS(4-FLUOROPHENYL)BUTYL]-4-[4-CHLORO-3(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL

4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-

4-piperidinol,1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethy

4-piperidinol,4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fl

McN-JR-16,341

Penfuridol

Semap

TLP-607

uorophenyl)butyl)-

R16341

PENFLURIDOL

PROTAMINE SULFATE USP

PENFLURIDOL CP2005

PHENFLURIDOL

1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

R16341, 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol

Penfluridol,1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

Five fluorine Lido

1-[4,4-BIS(4-FLUOROPHENYL)BUTYL]-4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-4-

Penfluridol Penfluridol

Penfluridol&gt

Penfluridol (R-16341)

Penfluridol USP/EP/BP

Penfluidol

Penfluridol/1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol

1-(4,4-Bis(4-fluorphenyl)butyl)-4-(4-chlor-3-(tri-fluormethyl)phe-nyl)-4-piperidinol

26864-56-2

C28H27ClF5NO

API

API intermediates

ONCOVIN