Penfluridol

ChemicalBook > CAS DataBase List > Penfluridol

Product Name: Penfluridol
CAS No.: 26864-56-2
Chemical Name: Penfluridol
Synonyms: Semap;R16341;TLP-607;Penfuridol;Penfluidol;PENFLURIDOL;PHENFLURIDOL;McN-JR-16,341;Penfluridol>Penfluridol, >=98%
CBNumber: CB8205397
Molecular Formula: C28H27ClF5NO
Formula Weight: 523.97
MOL File: 26864-56-2.mol

Less

Penfluridol Property

Melting point:: 105-107°C
Boiling point:: 587.7±50.0 °C(Predicted)
Density: 1.2425 (estimate)
storage temp.: 2-8°C
solubility: H₂O: insoluble
form: powder
pka: 13.49±0.20(Predicted)
color: white
Merck: 14,7087
CAS DataBase Reference: 26864-56-2(CAS DataBase Reference)
NIST Chemistry Reference: Penfluridol(26864-56-2)

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TN6957000
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990
Toxicity: LD50 orally in mice (day 7): 86.8 mg/kg (Janssen)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P3371
Product name: Penfluridol
Purity: ≥97% (HPLC), powder
Packaging: 50mg
Price: $175
Updated: 2024/03/01

TCI Chemical

Product number: P2076
Product name: Penfluridol
Purity: >98.0%(T)
Packaging: 1g
Price: $49
Updated: 2024/03/01

TCI Chemical

Product number: P2076
Product name: Penfluridol
Purity: >98.0%(T)
Packaging: 200mg
Price: $16
Updated: 2024/03/01

Cayman Chemical

Product number: 26071
Product name: Penfluridol
Purity: ≥98%
Packaging: 100mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 26071
Product name: Penfluridol
Purity: ≥98%
Packaging: 250mg
Price: $81
Updated: 2024/03/01

Less

Penfluridol Chemical Properties,Usage,Production

Originator

Semap,Janssen-Le Brun ,W. Germany ,1975

Uses

In terms of pharmacological action, penfluridol is similar to pimozide; however, it is significantly longer lasting, which is connected to the slow metabolism of the drug. Penfluridol is used as a supportive therapy in ambulatory settings for patients suffering from schizophrenia as well as patients with paranoid, psychotic, and neuroleptic conditions.

Uses

Penfluridol has been used as an antipsychotic agent:

to study its antimetastatic effect on triple-negative breast cancer cells
to study its effects on the growth of glioblastoma cell lines,
to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Uses

antineoplastic

Definition

ChEBI: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol is a diarylmethane.

Manufacturing Process

A mixture of 24 parts of 4,4-bis(p-fluorophenyl)butyl chloride, 20.9 parts of 4(4-chloro-α,α,α-trifluoro-m-tolyl)-4-piperidinol, 13.8 parts of sodium carbonate, a few crystals of potassium iodide in 600 parts of 4-methyl-2pentanone is stirred and refluxed for 60 hours. The reaction mixture is cooled and 150 parts of water is added. The organic layer is separated, dried, filtered and evaporated. The oily residue is crystallized from diisopropylether, yielding 4-(4chloro-α,α,α-trifluoro-m-tolyl)-1-[4,4-bis(p-fiuorophenyl)butyl]-4piperidinol; melting point 106.5°C.

brand name

Semap (Ortho-McNeil).

Therapeutic Function

Antipsychotic

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.

Safety Profile

Poison by ingestion and intravenous routes. Experimental teratogenic and reproductive effects. A neuroleptic agent. When heated to decomposition it emits very toxic fumes of Cl-, F-, and NOx.

Synthesis

Penfluridol, 4-(4-chloro-3-trifluoromethylphenyl)-1-[4,4-bis-(p-fluorophenyl) butyl]-4-piperidinol (6.6.12), is synthesized implementing a Grignard reaction between 1-carbomethoxypiperidin-4-one and 4-chloro-3-trifluoromethylphenylmagnesium bromide, giving 1-carbomethoxy-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol (6.6.10). Upon alkaline hydrolysis of the carbomethoxy group, it turns into (4-chloro-3-trifluoromethylphenyl)-4-piperidinol (6.6.11), the alkylation of which with 1,1-bis(4-fluorophenyl)butyl bromide (6.6.3) gives penfluridol (6.6.12) [67¨C69].

Penfluridol Preparation Products And Raw materials

Raw materials

Fluorobenzene

Preparation Products

N-Carbethoxy-4-piperidone

Less

Penfluridol Suppliers

Belgium 1 China 146 Europe 2 France 2 Germany 2 India 7 Japan 1 Switzerland 1 United Kingdom 4 United States 29 Global 195

Jiangsu Enhua Said Pharmaceutical Co., Ltd.

Tel: 0516-87767115
Fax: NULL
Email: nhwa@nhwa-group.com
Country: China
ProdList: 2
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2341
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel
Country: China
ProdList: 42982
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 4001
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9900
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22519
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8033
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7856
Advantage: 58

Shanghai Huikai Chemical Technology Co., Ltd.

Tel: 021-61995394 18916691159
Email: chemicalsea@163.com
Country: China
ProdList: 1975
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3123
Advantage: 55

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Shanghai Jovan Biochemical Technology Co. Ltd.

Tel: +86-021-61654350
Fax: +86-021-61654350
Email: 1245958370@qq.com
Country: China
ProdList: 2984
Advantage: 50

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-50266790 Q3382968513
Fax: QQ3382968513
Email: Hailey@shsendpharm.com
Country: China
ProdList: 3151
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10457
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1503
Advantage: 55

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9951
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Jinan Jason Pharmaceutical Co., Ltd.

Tel: 0531-82956131 15069164249
Fax: 0531-82956625
Email: jnjspharm@126.com
Country: China
ProdList: 1519
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28821
Advantage: 58

JinJin Le Chemical Co., Ltd

Tel: 10106090
Email: jjlchem2@163.com
Country: China
ProdList: 9986
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10335
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: 571-85586718 +8613336195806
Fax: +86-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 29797
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15085
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15503
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20569
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55896
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Hubei Jianwen Biomedical Co., Ltd.

Tel: 18372107314
Fax: 027-87887055
Email: 2332576826@qq.com
Country: China
ProdList: 102
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23556
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8617531190177
Email: peter@yan-xi.com
Country: China
ProdList: 6004
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Hebei Zhanyao Biotechnology Co. Ltd

Tel: 15369953316 +8615369953316
Email: admin@zhanyaobio.com
Country: China
ProdList: 2136
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28710
Advantage: 58

Less

View Lastest Price from Penfluridol manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Penfluridol 26864-56-2
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2023-07-21

Weijer International Trade (Hebei) Co., Ltd

Product: Penfluridol 26864-56-2
Price: US $80.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-22

Shanxi Naipu Import and Export Co.,Ltd

Product: Penfluridol 26864-56-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500tons/month
Release date: 2021-09-08

26864-56-2, Penfluridol Related Search:

Butyl acrylate Butyl acetate tert-Butylchlorodiphenylsilane DROPERIDOL 2,2,6,6-Tetramethyl-4-piperidinol Buprofezin 2-Butoxyethanol Phenylhydrazine PHENYL VALERATE Triacetonediamine Epichlorohydrin Haloperidol Difluorochloromethane 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL 4-(3-Trifuoromethyl)phenyl-4-piperidinol

1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol

1-[4,4-Bis(p-flurophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol

4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-

Penfluridol, >=98%

1-[4,4-BIS(4-FLUOROPHENYL)BUTYL]-4-[4-CHLORO-3(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL

4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-

4-piperidinol,1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethy

4-piperidinol,4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fl

McN-JR-16,341

Penfuridol

Semap

TLP-607

uorophenyl)butyl)-

R16341

PENFLURIDOL

PROTAMINE SULFATE USP

PENFLURIDOL CP2005

PHENFLURIDOL

1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

R16341, 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol

Penfluridol,1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

Five fluorine Lido

1-[4,4-BIS(4-FLUOROPHENYL)BUTYL]-4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-4-

Penfluridol Penfluridol

Penfluridol&gt

Penfluridol (R-16341)

Penfluridol USP/EP/BP

Penfluidol

Penfluridol/1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol

1-(4,4-Bis(4-fluorphenyl)butyl)-4-(4-chlor-3-(tri-fluormethyl)phe-nyl)-4-piperidinol

26864-56-2

C28H27ClF5NO

API

API intermediates

ONCOVIN