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Penfluridol

Product Name
Penfluridol
CAS No.
26864-56-2
Chemical Name
Penfluridol
Synonyms
Semap;R16341;TLP-607;Penfuridol;Penfluidol;PENFLURIDOL;PHENFLURIDOL;McN-JR-16,341;Penfluridol>Penfluridol, >=98%
CBNumber
CB8205397
Molecular Formula
C28H27ClF5NO
Formula Weight
523.97
MOL File
26864-56-2.mol
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Penfluridol Property

Melting point:
105-107°C
Boiling point:
587.7±50.0 °C(Predicted)
Density 
1.2425 (estimate)
storage temp. 
2-8°C
solubility 
H2O: insoluble
form 
powder
pka
13.49±0.20(Predicted)
color 
white
Merck 
14,7087
CAS DataBase Reference
26864-56-2(CAS DataBase Reference)
NIST Chemistry Reference
Penfluridol(26864-56-2)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
TN6957000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
Toxicity
LD50 orally in mice (day 7): 86.8 mg/kg (Janssen)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P3371
Product name
Penfluridol
Purity
≥97% (HPLC), powder
Packaging
50mg
Price
$175
Updated
2024/03/01
TCI Chemical
Product number
P2076
Product name
Penfluridol
Purity
>98.0%(T)
Packaging
1g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
P2076
Product name
Penfluridol
Purity
>98.0%(T)
Packaging
200mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
26071
Product name
Penfluridol
Purity
≥98%
Packaging
100mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
26071
Product name
Penfluridol
Purity
≥98%
Packaging
250mg
Price
$81
Updated
2024/03/01
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Penfluridol Chemical Properties,Usage,Production

Originator

Semap,Janssen-Le Brun ,W. Germany ,1975

Uses

In terms of pharmacological action, penfluridol is similar to pimozide; however, it is significantly longer lasting, which is connected to the slow metabolism of the drug. Penfluridol is used as a supportive therapy in ambulatory settings for patients suffering from schizophrenia as well as patients with paranoid, psychotic, and neuroleptic conditions.

Uses

Penfluridol has been used as an antipsychotic agent:

  • to study its antimetastatic effect on triple-negative breast cancer cells
  • to study its effects on the growth of glioblastoma cell lines,
  • to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Uses

antineoplastic

Definition

ChEBI: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol is a diarylmethane.

Manufacturing Process

A mixture of 24 parts of 4,4-bis(p-fluorophenyl)butyl chloride, 20.9 parts of 4(4-chloro-α,α,α-trifluoro-m-tolyl)-4-piperidinol, 13.8 parts of sodium carbonate, a few crystals of potassium iodide in 600 parts of 4-methyl-2pentanone is stirred and refluxed for 60 hours. The reaction mixture is cooled and 150 parts of water is added. The organic layer is separated, dried, filtered and evaporated. The oily residue is crystallized from diisopropylether, yielding 4-(4chloro-α,α,α-trifluoro-m-tolyl)-1-[4,4-bis(p-fiuorophenyl)butyl]-4piperidinol; melting point 106.5°C.

brand name

Semap (Ortho-McNeil).

Therapeutic Function

Antipsychotic

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.

Safety Profile

Poison by ingestion and intravenous routes. Experimental teratogenic and reproductive effects. A neuroleptic agent. When heated to decomposition it emits very toxic fumes of Cl-, F-, and NOx.

Synthesis

Penfluridol, 4-(4-chloro-3-trifluoromethylphenyl)-1-[4,4-bis-(p-fluorophenyl) butyl]-4-piperidinol (6.6.12), is synthesized implementing a Grignard reaction between 1-carbomethoxypiperidin-4-one and 4-chloro-3-trifluoromethylphenylmagnesium bromide, giving 1-carbomethoxy-(4-chloro-3-trifluoromethylphenyl)-4-piperidinol (6.6.10). Upon alkaline hydrolysis of the carbomethoxy group, it turns into (4-chloro-3-trifluoromethylphenyl)-4-piperidinol (6.6.11), the alkylation of which with 1,1-bis(4-fluorophenyl)butyl bromide (6.6.3) gives penfluridol (6.6.12) [67¨C69].

Penfluridol Preparation Products And Raw materials

Raw materials

Fluorobenzene

Preparation Products

N-Carbethoxy-4-piperidone
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Penfluridol Suppliers

Belgium 1 China 146 Europe 2 France 2 Germany 2 India 7 Japan 1 Switzerland 1 United Kingdom 4 United States 29 Global 195
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Penfluridol manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
Penfluridol 26864-56-2
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2023-07-21
Weijer International Trade (Hebei) Co., Ltd
Product
Penfluridol 26864-56-2
Price
US $80.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
20tons
Release date
2023-03-22
Shanxi Naipu Import and Export Co.,Ltd
Product
Penfluridol 26864-56-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500tons/month
Release date
2021-09-08

26864-56-2, Penfluridol Related Search:

Butyl acrylate Butyl acetate tert-Butylchlorodiphenylsilane DROPERIDOL 2,2,6,6-Tetramethyl-4-piperidinol Buprofezin 2-Butoxyethanol Phenylhydrazine PHENYL VALERATE Triacetonediamine Epichlorohydrin Haloperidol Difluorochloromethane 4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL 4-(3-Trifuoromethyl)phenyl-4-piperidinol

  • 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol
  • 1-[4,4-Bis(p-flurophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol
  • 4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-
  • Penfluridol, >=98%
  • 1-[4,4-BIS(4-FLUOROPHENYL)BUTYL]-4-[4-CHLORO-3(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL
  • 4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-
  • 4-piperidinol,1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethy
  • 4-piperidinol,4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fl
  • McN-JR-16,341
  • Penfuridol
  • Semap
  • TLP-607
  • uorophenyl)butyl)-
  • R16341
  • PENFLURIDOL
  • PROTAMINE SULFATE USP
  • PENFLURIDOL CP2005
  • PHENFLURIDOL
  • 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol
  • R16341, 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol
  • Penfluridol,1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341
  • Five fluorine Lido
  • 1-[4,4-BIS(4-FLUOROPHENYL)BUTYL]-4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-4-
  • Penfluridol Penfluridol
  • Penfluridol&gt
  • Penfluridol (R-16341)
  • Penfluridol USP/EP/BP
  • Penfluidol
  • Penfluridol/1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol
  • 1-(4,4-Bis(4-fluorphenyl)butyl)-4-(4-chlor-3-(tri-fluormethyl)phe-nyl)-4-piperidinol
  • 26864-56-2
  • C28H27ClF5NO
  • API
  • API intermediates
  • ONCOVIN