1-(2-Amino-3-methoxyphenyl)ethan-1-one
- Product Name
- 1-(2-Amino-3-methoxyphenyl)ethan-1-one
- CAS No.
- 42465-54-3
- Chemical Name
- 1-(2-Amino-3-methoxyphenyl)ethan-1-one
- Synonyms
- 1-(2-Amino-3-methoxyphenyl);2’-Amino-3’-methoxyacetophenone;1-(2-Amino-3-methoxy-phenyl)-ethanone;Ethanone,1-(2-amino-3-methoxyphenyl)-
- CBNumber
- CB82077374
- Molecular Formula
- C9H11NO2
- Formula Weight
- 165.19
- MOL File
- 42465-54-3.mol
1-(2-Amino-3-methoxyphenyl)ethan-1-one Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C9H11NO2/c1-6(11)7-4-3-5-8(12-2)9(7)10/h3-5H,10H2,1-2H3
- InChIKey
- RHVYWYRETWKHDC-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC(OC)=C1N)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H313May be harmful in contact with skin
H317May cause an allergic skin reaction
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- 5856AB
- Product name
- 1-(2-Amino-3-methoxyphenyl)ethanone
- Packaging
- 100mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- FA11527
- Product name
- 1-(2-Amino-3-methoxyphenyl)ethanone
- Packaging
- 50mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 5856AB
- Product name
- 1-(2-Amino-3-methoxyphenyl)ethanone
- Packaging
- 1g
- Price
- $308
- Updated
- 2021/12/16
- Product number
- CHM0386658
- Product name
- 1-(2-AMINO-3-METHOXYPHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.65
- Updated
- 2021/12/16
- Product number
- FA11527
- Product name
- 1-(2-Amino-3-methoxyphenyl)ethanone
- Packaging
- 500mg
- Price
- $600
- Updated
- 2021/12/16
1-(2-Amino-3-methoxyphenyl)ethan-1-one Chemical Properties,Usage,Production
Uses
1-(2-Amino-3-methoxyphenyl)ethan-1-one is a versatile compound that can be used as a raw material for organic synthesis or as a component in pharmaceutical intermediates.
General Description
1-(2-Amino-3-methoxyphenyl)ethan-1-one can be used in the preparation of cinnoline and quinoline 4-amine derivatives.
Synthesis
33852-43-6
42465-54-3
The general steps for the synthesis of 1-(2-amino-3-methoxy-phenyl)-acetophenone from 3'-methoxy-2'-nitroacetophenone are as follows: Step 1. Preparation of 3-methoxy-2-amino benzaldehyde A 1:1 mixture of ethanol and acetic acid was used as reaction solvent and 3-methoxy-2-nitrobenzaldehyde (1 eq.) and iron powder (3 eq.) were added in batches. The reaction was completed within 3 hours. Upon completion of the reaction, the reaction mixture was filtered and subsequently concentrated. The concentrate was partitioned between ethyl acetate and water. The organic layer was washed with saturated sodium bicarbonate solution, dried and concentrated to give 2-amino-3-methoxybenzaldehyde in 85% yield.ES/MS m/z 151 (MH+).
References
[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 348
[2] Journal of Organic Chemistry, 2007, vol. 72, # 18, p. 6873 - 6877
[3] Patent: US4620000, 1986, A
[4] Patent: US4666499, 1987, A
[5] Patent: US2011/144115, 2011, A1. Location in patent: Page/Page column 7
1-(2-Amino-3-methoxyphenyl)ethan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2-Amino-3-methoxyphenyl)ethan-1-one manufacturers
- Product
- Ethanone,1-(2-amino-3-methoxyphenyl)- 42465-54-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-11