Description References
ChemicalBook > CAS DataBase List > Trehalose

Trehalose

Description References
Product Name
Trehalose
CAS No.
99-20-7
Chemical Name
Trehalose
Synonyms
α,α-trehalose;D-TREHALOSE;MYCOSE;alpha,alpha-Trehalose;alpha-d-glucopyranoside;Trehalose RS;Trehalose solution;TREHALOSE;Crehalose;Trehelose
CBNumber
CB8210805
Molecular Formula
C12H22O11
Formula Weight
342.3
MOL File
99-20-7.mol
More
Less

Trehalose Property

Melting point:
203 °C
Boiling point:
397.76°C (rough estimate)
Density 
1.5800
vapor pressure 
0.001Pa at 25℃
refractive index 
197 ° (C=7, H2O)
RTECS 
LZ5776770
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in water; very slightly soluble in ethanol (95%); practically insoluble in ether.
pka
12.53±0.70(Predicted)
form 
Powder
color 
White to Off-white
optical activity
+197+178
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
Merck 
14,9580
LogP
0 at 25℃
CAS DataBase Reference
99-20-7(CAS DataBase Reference)
EPA Substance Registry System
Trehalose (99-20-7)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
37/39-26
TSCA 
Yes
HS Code 
29400090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S410241
Product name
D(+)-TREHOLOSE
Purity
AldrichCPR
Packaging
1G
Price
$172
Updated
2023/06/20
TCI Chemical
Product number
T0832
Product name
D-(+)-Trehalose Anhydrous
Purity
>98.0%(GC)
Packaging
5g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
T0832
Product name
D-(+)-Trehalose Anhydrous
Purity
>98.0%(GC)
Packaging
25g
Price
$81
Updated
2024/03/01
Alfa Aesar
Product number
J66006
Product name
D-(+)-Trehalose, anhydrous
Packaging
5g
Price
$31.9
Updated
2024/03/01
Alfa Aesar
Product number
J66006
Product name
D-(+)-Trehalose, anhydrous
Packaging
10g
Price
$49.2
Updated
2024/03/01
More
Less

Trehalose Chemical Properties,Usage,Production

Description

Trehalose is a nonreducing disaccharide in which the two glucose molecules are linked together in an α,α-1,1-glycosidic linkage. α,α-trehalose is the only anomer of trehalose, which has been isolated from and biosynthesized in living organisms. This sugar is present in a wide variety of organisms, including bacteria, yeast, fungi, insects, invertebrates, and lower and higher plants, where it may serve as a source of energy and carbon.  It can be used as a stabilizer and protectant of proteins and membranes: protection from dehydration; protection from damage by oxygen radicals (against oxidation); protection from cold; as a sensing compound and/or growth regulator; as a structural component of the bacterial cell wall. Trehalose is used in the biopharmaceutical preservation of labile protein drugs and in the cryopreservation of human cells. It is used as an ingredient for dried and processed food, and as an artificial sweetener, with a relative sweetness of 40-45% that of sucrose. Several safety studies on trehalose have been evaluated by JECFA, 2001 and allocated an ADI of ‘not specified’. Trehalose is approved in Japan, Korea, Taiwan, and UK. Trehalose could be possibly used in an eye drop solution to against corneal damage due to desiccation (dry eye syndrome).

References

[1] Alan D. Elbein, Y.T. Pan, Irena Pastuszak, David Carroll (2003): New insights on trehalose: a multifunctional molecule, 13, 17R-27R.
[2] A.B Richards, S Krakowka, L.B Dexter, H Schmid, A.P.M Wolterbeek, D.H Waalkens-Berendsen, A Shigoyuki, M Kurimoto (2002): Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies, 40, 871-898.
[3] Alex Patist, Hans Zoerb (2005): Preservation mechnisams of trehalose in food and Biosystems, 40, 107-113.
[4] Sanchari Chattopadhyay, Utpal Raychaudhuri, Runu Chakraborty (2014): Artificial sweeteners – a review, 51, 611-621.
[5] http://www.life-enhancement.com/magazine/article/2453-trehalose-for-dry-eyes

Chemical Properties

white to off-white crystalline powder

Chemical Properties

Trehalose occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).

Uses

trehalose is a humectant and moisturizer, it helps bind water in the skin and increase the skin’s moisture content. It is a naturally occurring plant sugar.

Uses

D-(+)-Trehalose can be used for the effects of sucrose on blood avidity in mosquitoes.

Production Methods

Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.

Definition

ChEBI: A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Trehalose is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.

Safety

Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg

storage

Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.

Incompatibilities

Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.

Regulatory Status

GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.

Trehalose Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Trehalose Suppliers

Belgium 1 Canada 1 China 443 Europe 2 France 1 Germany 7 India 11 Italy 2 Japan 6 Spain 1 Switzerland 3 The Netherlands 1 United Kingdom 7 United States 43 Global 529
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
18478
Advantage
58
BOC Sciences
Tel
16314854226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
9713
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Penta Manufacturing Company (a division of Penta International Corporation)
Tel
--
Fax
--
Email
@pentamfg.com
Country
United States
ProdList
901
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Pfanstiehl, Inc.
Tel
--
Fax
--
Email
cs@pfanstiehl.com
Country
United States
ProdList
13
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
NutriScience Innovations, LLC
Tel
--
Fax
--
Email
sales@nutriscienceusa.com
Country
United States
ProdList
141
Advantage
64
ECSA Chemicals
Tel
--
Fax
--
Email
marketing@ecsa.ch
Country
United States
ProdList
1735
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
Jiangyin Healthway International Trade Co., Ltd
Tel
--
Fax
--
Email
info@healthwaychem.com
Country
United States
ProdList
1006
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Omicron Biochemicals, Inc.
Tel
--
Fax
--
Email
omicron@omicronbio.com
Country
United States
ProdList
580
Advantage
64
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
SynInnova Laboratories Inc.
Tel
--
Fax
--
Email
sales@syninnova.com
Country
United States
ProdList
491
Advantage
50
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Amfinecom Inc.
Tel
--
Fax
--
Email
sales@amfinecom.com
Country
United States
ProdList
3062
Advantage
50
Reagent World
Tel
--
Fax
--
Email
Sales@ReagentWorld.com
Country
United States
ProdList
1637
Advantage
50
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Naugra Export
Tel
--
Fax
--
Country
United States
ProdList
1332
Advantage
47
Loba Chemie Pvt. Ltd.
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
71
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
Kiran Light Laboratories
Tel
--
Fax
--
Country
United States
ProdList
863
Advantage
43
More
Less

View Lastest Price from Trehalose manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Trehalose 99-20-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-27
Hebei Longbang Technology Co., Ltd
Product
Trehalose 99-20-7
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-06
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Trehalose 99-20-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-22

99-20-7, TrehaloseRelated Search:

D(+)-Trehalose dihydrate Trehalose TREHALOSE OCTAACETATE Actinotetraose Hexatiglate TRIMETHYLSILYL-D(+)TREHALOSE α,α-trehalose glucohydrolase trehalose 6,6'-dimycolate from mycobacterium tuberculosis,6,6'-di-o-mycoloyl-α,α-trehalose,TREHALOSE 6,6'-DIMYCOLATE FROM*MYCOBACTE RIUM TUBERC Trehalose 6-phosphate 6,6'-dibehenoyl-α,α'-trehalose trehalose synthase ALPHA,SS-TREHALOSE OCTAACETATE trehalose-6-phosphate synthase-phosphatase complex 4-azido-4-deoxy-alpha,alpha-trehalose alpha,alpha-trehalose phosphorylase alpha,alpha-trehalose-phosphate synthase(GDP-forming) TREHALOSE, ALPHA-D-, [14C(U)] 3-deoxymaltosyl-1-4-alpha,alpha-trehalose trehalose 6,6'-dipalmitate

  • D-(+)-TREHALOSE
  • D-TREHALOSE
  • (2R,2'R,3S,3'S,4S,4'S,5R,5'R,6R,6'R)-6,6'-oxybis(2-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol)
  • TREHALOSE(P)
  • ALPHA-D-TREHALOSE
  • ALPHA,ALPHA-D-TREHALOSE
  • MYCOSE
  • TREHALOSE
  • .alpha.-D-Glucopyranoside,.alpha.-D-glucopyranosyl
  • alpha,alpha'-Trehalose
  • alpha,alpha-Trehalose
  • alpha-d-glucopyranoside,alpha-d-glucopyranosyl
  • alpha-Trehalose
  • d-trehaloseanhydrous
  • Ergot sugar
  • Hexopyranosyl hexopyranoside
  • Natural trehalose
  • 1,1'-Oxybis(1-deoxy-α-D-glucopyranose)
  • alpha,alpha-Trehalose,99+%
  • Trehalose anhydrous
  • α,α-[1,1'-2H2]trehalose
  • α,α-[UL-2H14]trehalose
  • Nano Liposomal D-Trehalose anhydrous
  • a,a-Trehalose anhydrous
  • D(+)-Trehalose anhydrous≥ 99% (HPLC)
  • α-D-Glucopyranosyl-α-D-glucopyranoside anhydrous
  • 1-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE
  • trehalose supplier
  • D-A-A-TrehaloseDihydrate,~99%
  • TrehaloseForBiochemistry
  • à-d-glucopyranosyl-à-d-glucopyranoside
  • 2-(hydroxymethyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxane-3,4,5-triol
  • TREHALOSE, D-(+)-(RG)
  • .alpha.-D-Glucopyranoside
  • .alpha.-D-glucopyranosyl
  • alpha-d-glucopyranoside
  • alpha-d-glucopyranosyl
  • D-Trehalose, 99%, anhydrous
  • A-D-GLUCOPYRANOSYL-A-D-GLUCOPYRANOSIDE ANHYDROUS
  • D-(+)-TREHALOSE ANHYDRIDE
  • D-(+)-TREHALOSE;Α-D-GLUCOPYRANOSYL-Α-D-GLUCOPYRANOSIDE
  • 1-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSID
  • D-(+)-TrehaloseAnhydrous&gt
  • Trehalose RS
  • α-D-Glucopyranoside, α-D-glucopyranosyl
  • Trehalose anhydray
  • α,α-trehalose
  • TREHALOSE USP/EP/BP
  • TREHALOSE ACID
  • Trehalose solution
  • Factory Price Trehalose CAS 99-20-7 Trehalose
  • D-Trehalose anhydrous 99%
  • Crehalose
  • 2-AMINOTEREPHTHALIC ACID 10312-55-7
  • α,α-[UL-13C12]trehalose
  • Trehalose (8CI)
  • Trehelose
  • UL-13C12]-α,α-trehalose