ChemicalBook > CAS DataBase List > TREHALOSE 6,6'-DIMYCOLATE

TREHALOSE 6,6'-DIMYCOLATE

Product Name
TREHALOSE 6,6'-DIMYCOLATE
CAS No.
61512-20-7
Chemical Name
TREHALOSE 6,6'-DIMYCOLATE
Synonyms
CORD FACTOR;Trehalose dimycolate;6,6-TREHALOSE DIMYCOLATE;TREHALOSE 6,6'-DIMYCOLATE;6,6'-di-o-mycoloyl-α,α-trehalose;Cord factor from Mycobacterium bovis;TREHALOSE 6,6′-DIMYCOLATE;CORD FACTOR;6,6'-DI-O-MYCOLOYL-ALPHA,ALPHA-TREHALOSE;6,6μ-Di-O-mycoloyl-α,α-trehalose, Cord factor;trehalose 6,6'-dimycolate from*mycobacterium tube
CBNumber
CB1389627
Molecular Formula
C130H250O15.C2H6
Formula Weight
0
MOL File
Mol file
More
Less

TREHALOSE 6,6'-DIMYCOLATE Property

storage temp. 
−20°C
form 
Powder
color 
White to off-white
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3034
Product name
Trehalose 6,6′-dimycolate from Mycobacterium bovis
Purity
≥97% 6,6′-mycolate esters basis
Packaging
1mg
Price
$173
Updated
2022/05/15
Sigma-Aldrich
Product number
T3034
Product name
Trehalose 6,6′-dimycolate from Mycobacterium bovis
Purity
≥97% 6,6′-mycolate esters basis
Packaging
2.5mg
Price
$340
Updated
2022/05/15
American Custom Chemicals Corporation
Product number
CRB0003510
Product name
TREHALOSE-6,6'-DIMYCOLATE
Purity
95.00%
Packaging
1MG
Price
$411.6
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
108402
Product name
Trehalose6-6?-dimycolate
Packaging
1mg
Price
$475
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CRB0003510
Product name
TREHALOSE-6,6'-DIMYCOLATE
Purity
95.00%
Packaging
5MG
Price
$499.64
Updated
2021/12/16
More
Less

TREHALOSE 6,6'-DIMYCOLATE Chemical Properties,Usage,Production

Uses

Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses[1][2].

in vivo

1. Induce inflammation and granuloma formation[1]
Pathogenic mechanism
Trehalose 6,6’-dimycolate prevents calcium-mediated fusion of phagosomes and lysosomes, inhibits phagolysosome acidification, and thereby inhibits the killing effect of mouse macrophages on Mycobacterium tuberculosis, impairs the body's effective immune response, and induces the expression of matrix metalloproteinases.
Specific modeling method
Mice: C57BL/6 ? female ? 6-8 week-old (period: 7 days)
Administration: 0.5 or 1.25 mg/kg ? i.v., or i.p. first then i.v. ? once
Modeling success index
Phenotypic observation ：Macrophages gather locally, the size and number of granulomas increase, inflammation intensifies, alveolar spaces decrease, there are small hemorrhages, and lymphocytes mainly infiltrate at the junction of granulomas and blood vessels.
Animal Model:Female C57BL/6 mice (6-8 weeks, 20 g)[1]
Dosage:0.5, 1.25 mg/kg (10 μg, 25 μg per 20 g mice)
Administration:Intravenous injection (i.v.) once (0.5, 1.25 mg/kg), or received 0.5 mg/kg via Intraperitoneal injection (i.p.) followed by an i.v. after 7 days of 0.5 mg/kg
Result:Increased the lung weight index (LWI). Local aggregation of macrophages was observed 7 days later at 0.5 mg/kg. The size and number of granulomas increased, inflammation intensified, alveolar spaces decreased, small hemorrhagic petechiae appeared, and lymphocytes mainly infiltrated at the intersection of granulomas and blood vessels at 1.25 mg/kg. In i.p.+i.v. model, the inflammatory response was more aggressive. Induced vascular remodeling and collagen deposition.

References

[1] Hwang SA, et al. Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation. Tuberculosis (Edinb). 2019 May;116S:S118-S122. DOI:10.1016/j.tube.2019.04.019
[2] Welsh KJ, et al. Trehalose 6,6'-dimycolate--a coat to regulate tuberculosis immunopathogenesis. Tuberculosis (Edinb). 2013 Dec;93 Suppl:S3-9. DOI:10.1016/S1472-9792(13)70003-9

TREHALOSE 6,6'-DIMYCOLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TREHALOSE 6,6'-DIMYCOLATE Suppliers

China 21 Japan 1 Switzerland 1 United Kingdom 2 United States 4 Global 29
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
BOC Sciences
Tel
16314854226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
9713
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58

61512-20-7, TREHALOSE 6,6'-DIMYCOLATERelated Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE SALCOMINE Benzyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate Tosylmethyl isocyanide N-BUTYLISOCYANIDE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE Ferric acetylacetonate Cupric acetylacetonate Trehalose

  • TREHALOSE 6,6'-DIMYCOLATE
  • CORD FACTOR
  • TREHALOSE 6,6'-DIMYCOLATE FROM*MYCOBACTE RIUM TUBERC
  • 6,6'-di-o-mycoloyl-α,α-trehalose
  • trehalose 6,6'-dimycolate from mycobacterium tuberculosis
  • 6,6μ-Di-O-mycoloyl-α,α-trehalose, Cord factor
  • 6,6'-DI-O-MYCOLOYL-ALPHA,ALPHA-TREHALOSE
  • Trehalose 6,6′-diMycolate froM MycobacteriuM bovis
  • 6,6′-Di-O-mycoloyl-α,α-trehalose from Mycobacterium bovis
  • Cord factor from Mycobacterium bovis
  • Trehalose dimycolate
  • TREHALOSE 6,6′-DIMYCOLATE;CORD FACTOR
  • trehalose 6,6'-dimycolate from*mycobacterium tube
  • Trehalose 6,6'-dimycolate [Cord Factor] Endotoxin-free (sterile)
  • 6,6-TREHALOSE DIMYCOLATE
  • 61512-20-7
  • C130H250O15C2H6
  • Biochemicals and Reagents
  • BioChemical
  • Carbohydrates
  • Disaccharide