ChemicalBook > CAS DataBase List > Bromfenac Sodium

Bromfenac Sodium

Product Name
Bromfenac Sodium
CAS No.
120638-55-3
Chemical Name
Bromfenac Sodium
Synonyms
Duract;Unii-8ecv571Y37;Bromfenac sodiu;Bromfenac sodium;Bromfenac ophthalmic;acetate hydrate(2:2:3);Bromfenac sodium hydrate;BroMfenac sodiuM 1.5H2O;Sodium bromfenate hydrate;Sodium bromofenac 15 hydrate
CBNumber
CB82130312
Molecular Formula
C15H11BrNNaO3
Formula Weight
356.15
MOL File
120638-55-3.mol
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Bromfenac Sodium Property

Melting point:
268-270°C (dec.)
storage temp. 
Refrigerator
solubility 
DMSO: ≥ 100 mg/mL (260.98 mM); Water: ≥ 100 mg/mL (260.98 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Signal word
Danger
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N-Bromosuccinimide Price

TRC
Product number
B678550
Product name
BromfenacSodiumSesquihydrate
Packaging
50mg
Price
$235
Updated
2021/12/16
Matrix Scientific
Product number
098118
Product name
Sodium 2-(2-amino-3-(4-bromobenzoyl)-phenyl)acetate trihydrate
Purity
95+%
Packaging
10g
Price
$315
Updated
2021/12/16
ChemScene
Product number
CS-5737
Product name
Bromfenacsodiumhydrate
Purity
99.70%
Packaging
200mg
Price
$336
Updated
2021/12/16
AK Scientific
Product number
R722
Product name
Bromfenacmonosodiumsaltsesquihydrate
Packaging
50mg
Price
$380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000432
Product name
BROMFENAC SODIUM
Purity
95.00%
Packaging
10MG
Price
$704.55
Updated
2021/12/16
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Bromfenac Sodium Chemical Properties,Usage,Production

Description

Duract was launched in the US as a potent, orally-active, long lasting peripheral analgesic with antiinflammatory properties. It is structurally similar to ketoprofen and diclofenac and can be prepared in three steps from 2-amino-4’-bromophenone using Gassman’s oxindole synthesis. Duract’s biological effects are a result of its ability to reduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromo derivative of Amfenac, this modification increased the duration of analgesic activity and antiinflammatory potency. It was also free of any CNS, cardiovascular or autonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASA and 25 mg was slightly more potent than 400 mg of Ibuprofen.

Chemical Properties

Yellow Solid

Originator

American Home Products (US)

Uses

Bromfenac (Xibrom, ISTA Pharmaceuticals, Irvine, USA; Bronuck, Senju Pharmaceutical, Osaka, Japan) is indicated for the treatment of postoperative inflammation and the reduction of ocular pain in patients after undergoing cataract extraction. For this task, one drop of Xibrom may be applied to the affected eye twice daily beginning 24 hours after cataract surgery and continuing for the first 2 weeks of the postoperative period. The clinical safety and efficacy of bromfenac have been extensively studied in diverse comparative investigations, including the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, scleritis, and postoperative inflammation.The results of two phase III multicenter, randomized double-masked placebo-controlled clinical trials showed that bromfenac ophthalmic solution 0.09% was effective in the rapid resolution of ocular pain after cataract surgery, and there was a statistically significant difference between the bromfenac and placebo groups demonstrated in these phase III clinical trials.

Uses

Bromfenac is a non-steroidal anti-inflammatory agent.

Definition

ChEBI: The sesquihydrate of the sodium salt of bromfenac. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction.

brand name

Xibrom (Ista).

Bromfenac Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bromfenac Sodium manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Bromfenac Sodium Sesquihydrate 120638-55-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Zibo Wei Bin Import & Export Trade Co. Ltd.
Product
Bromfenac Sodium 120638-55-3
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10
Release date
2023-07-11
Hebei Mojin Biotechnology Co., Ltd
Product
Bromfenac Sodium 120638-55-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-01

120638-55-3, Bromfenac SodiumRelated Search:


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