ChemicalBook > CAS DataBase List > N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

Product Name: N-(TERT-BUTOXYCARBONYL)-D-PROLINAL
CAS No.: 73365-02-3
Chemical Name: N-(TERT-BUTOXYCARBONYL)-D-PROLINAL
Synonyms: (R)-tert-butyl 2-forMylpyrrolidine-1-carboxylate;Boc-D-prolyne;BOC-D-PROLINAL;(R)-N-BOC-PROLINAL;N-T-BOC-D-PROLINAL;(R)-N-BOC-PROLINAL, 97+%;(R)-1-Boc-2-formylpyrrolidine;N-(TERT-BUTOXYCARBONYL)-D-PROLINAL;(R)-(+)-1-BOC-2-PYRROLIDINECARBALDEHYDE;S-(+)-N-(diphenylmethylene)glycinesultam
CBNumber: CB8215406
Molecular Formula: C10H17NO3
Formula Weight: 199.25
MOL File: 73365-02-3.mol

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N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Property

Boiling point:: 228 °C(lit.)
alpha: +83°(23℃, neat)
Density: 1.059 g/mL at 25 °C(lit.)
refractive index: n20/D 1.461(lit.)
Flash point:: >230 °F
storage temp.: -20°C
form: Liquid
pka: -3.03±0.40(Predicted)
Specific Gravity: 1.059
color: Colorless to yellow
optical activity: [α]23/D +83°, neat
Sensitive: Air Sensitive
InChI: InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h7-8H,4-6H2,1-3H3/t8-/m1/s1
InChIKey: YDBPZCVWPFMBDH-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@@H]1C=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 483788
Product name: N-(tert-Butoxycarbonyl)-D-prolinal
Purity: 97%
Packaging: 1g
Price: $49.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: 483788
Product name: N-(tert-Butoxycarbonyl)-D-prolinal
Purity: 97%
Packaging: 5g
Price: $395
Updated: 2023/06/20

TCI Chemical

Product number: B5395
Product name: N-(tert-Butoxycarbonyl)-D-prolinal
Packaging: 1G
Price: $93
Updated: 2025/07/31

Usbiological

Product number: 265613
Product name: Boc-D-prolinal
Packaging: 500mg
Price: $382
Updated: 2021/12/16

Matrix Scientific

Product number: 074620
Product name: N-Boc-D-Prolinal
Purity: 95+%
Packaging: 10g
Price: $395
Updated: 2021/12/16

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N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

59378-81-3

73365-02-3

1. tert-Butyl (2R)-2-formylpyrrolidine-1-carboxylate (15.9 g, 37.4 mmol) was added in batches to a stirring solution of tert-Butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (5.0 g, 24.9 mmol) in dichloromethane (75 mL) under nitrogen protection over a 5-minute dosing period. 2. The reaction mixture was stirred for 1 hr. to form a suspension.3. The suspension was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (100 mL).4. The filtrate was concentrated under pressure to give the crude product.5. The crude product was purified by neutral silica gel column chromatography to give BOC-D-prolinyl aldehyde (4.4 g, 89% yield) using 12% ethyl acetate/hexanes as eluent.

References

[1] Patent: WO2015/120390, 2015, A1. Location in patent: Page/Page column 97; 178
[2] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[3] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 94; 95
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 12, p. 3190 - 3198
[5] Tetrahedron Letters, 1990, vol. 31, # 28, p. 3957 - 3960

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(TERT-BUTOXYCARBONYL)-D-PROLINAL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Boc-D-prolinal 73365-02-3
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Nanjing Fred Technology Co., Ltd

Product: N-Boc-D-Prolinal 73365-02-3
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98%(GC);99%ee
Supply Ability: 500kg
Release date: 2023-12-06

Career Henan Chemical Co

Product: N-(TERT-BUTOXYCARBONYL)-D-PROLINAL 73365-02-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

73365-02-3, N-(TERT-BUTOXYCARBONYL)-D-PROLINALRelated Search:

N-(TERT-BUTOXYCARBONYL)-L-PROLINAL,(S)-N-Boc-pyrrolidine-2-carboxaldehyde, N-(tert-Butoxycarbonyl)-L-prolinal (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid BOC-D-PRO-OSU D-1-N-Boc-prolinamide N-(TERT-BUTOXYCARBONYL)-D-PROLINAL (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-PRO-OME (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate BOC-D-PRO-D-PHE-OH (R)-2-(2-ETHOXYCARBONYL-ACETYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-D-PRO-GLY-OH BOC-D-PRO-PAM RESIN (R)-4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER BOC-CIS-3-HYDROXY-D-PROLINE BOC-D-PRO-PHE-OH (2R,5S)-BOC-5-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID BOC-(S)-ALPHA-BENZYL-PROLINE AKOS 92832

(R)-2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-(+)-1-BOC-2-PYRROLIDINECARBALDEHYDE

(R)-N-BOC-PROLINAL

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

N-T-BOC-D-PROLINAL

BOC-D-PROLINAL

(R)-2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-N-BOC-PROLINAL

(R)-N-BOC-PROLINAL, 97+%

S-(+)-N-(diphenylmethylene)glycinesultam

1-Pyrrolidinecarboxylicacid, 2-formyl-, 1,1-dimethylethyl ester, (2R)-

(R)-tert-butyl 2-forMylpyrrolidine-1-carboxylate

(R)-1-Boc-2-formylpyrrolidine

tert-butyl (2R)-2-formylpyrrolidine-1-carboxylate

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL USP/EP/BP

Boc-D-prolyne

<i>N</i>-(<i>tert</i>-Butoxycarbonyl)-<sc>D</sc>-prolinal

73365-02-3

Amino Acid Derivatives

Amino Aldehydes

Specialty Synthesis

Peptide Synthesis

Amino Aldehydes

Amino Acid Derivatives

Peptide Synthesis