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(R)-BEL

Product Name
(R)-BEL
CAS No.
478288-90-3
Chemical Name
(R)-BEL
Synonyms
(R)-BEL;(R)-BROMOENOL LACTONE;(R) Bromoenol lactone,(R)Bromoenol lactone;(3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one;6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE;2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
CBNumber
CB8215769
Molecular Formula
C16H13BrO2
Formula Weight
317.18
MOL File
478288-90-3.mol
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(R)-BEL Property

Boiling point:
467.0±45.0 °C(Predicted)
Density 
1.538±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
10006800
Product name
(R)-Bromoenol lactone
Purity
≥98%
Packaging
10mg
Price
$365
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
HCH0105431
Product name
6E-(BROMOETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
Purity
95.00%
Packaging
5MG
Price
$503.38
Updated
2021/12/16
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(R)-BEL Chemical Properties,Usage,Production

Description

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 μM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM.

References

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2 Annu. Rev. Pharmacol. Toxicol. 39,175-189(1999).
2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells J. Biol. Chem. 277(36),32807-32814(2002).

(R)-BEL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-BEL Suppliers

China 7 United States 3 Global 10
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

478288-90-3, (R)-BELRelated Search:

Ethyl 1-naphthaleneacetate VINYL PHENYL ACETATE (R)-BEL Methyl naphthalene-1-acetate BROMOENOL LACTONE

  • (R)-BEL
  • (R)-BROMOENOL LACTONE
  • 6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
  • (3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
  • (R) Bromoenol lactone,(R)Bromoenol lactone
  • 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
  • 478288-90-3