ChemicalBook > CAS DataBase List > NORTRIPTYLINE HYDROCHLORIDE

NORTRIPTYLINE HYDROCHLORIDE

Product Name
NORTRIPTYLINE HYDROCHLORIDE
CAS No.
894-71-3
Chemical Name
NORTRIPTYLINE HYDROCHLORIDE
Synonyms
Vividyl;Acetexa;pamelor;Sensival;Norzepine;nortrilen;Norfenazin;aventylallegron;NORTRIPTYLINE HCL;Desitriptyline HCl
CBNumber
CB8218917
Molecular Formula
C19H22ClN
Formula Weight
299.84
MOL File
894-71-3.mol
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NORTRIPTYLINE HYDROCHLORIDE Property

Melting point:
217-220?C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
ethanol: 100 mg/mL
form 
powder
color 
white to off-white
λmax
237nm(H2O)(lit.)
Merck 
14,6715
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/38-23/25-11-39/23/24/25-23/24/25
Safety Statements 
22-36-45-24-16-7-36/37
RIDADR 
UN 1230 3/PG 2
WGK Germany 
3
RTECS 
HP0175000
HS Code 
2921490002
Toxicity
LD50 oral in rat: 405mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3216
Product name
Nortriptyline Hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$230
Updated
2024/03/01
Sigma-Aldrich
Product number
N-907
Product name
Nortriptyline hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$27.7
Updated
2024/03/01
Sigma-Aldrich
Product number
N7261
Product name
Nortriptyline hydrochloride
Purity
≥98% (TLC), powder
Packaging
10g
Price
$80.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1474005
Product name
Nortriptyline hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
N0957
Product name
Nortriptyline Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$34
Updated
2024/03/01
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NORTRIPTYLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Aventyl,Lilly,UK,1963

Uses

Nortriptyline Hydrochloride (Amitriptyline EP Impurity C) is a tricyclic antidepressant.

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Definition

ChEBI: Nortriptyline hydrochloride is an organic tricyclic compound. It has a role as a geroprotector.

Manufacturing Process

A mixture of 114.5 g of 5-(3-chloropropylidene)dibenzo[a,d]cyclohepta[1,4] diene, 75 ml of benzene, and about 400 ml of methylamine is heated in an autoclave at 120°C for six hours. The excess methylamine is distilled from the reaction mixture under vacuum and the residue is stirred with 300 ml of water. Acidification of the mixture with hydrochloric acid causes the separation of the hydrochloride of 5-(3-methylaminopropylidene)dibenzo[a,d] cyclohepta[1,4]diene. The product is collected by filtration and is purified by recrystallization from a mixture of absolute ethanol and ethyl acetate. MP 210°C to 212°C.

brand name

Aventyl Hydrochloride (Lilly); Aventyl Hydrochloride (Ranbaxy); Pamelor (Tyco).

Therapeutic Function

Antidepressant

General Description

Pertinent biological and chemical properties for nortriptyline,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)Nmethyl-1-propanamine hydrochloride, 5-(3-methyl-aminopropylidene)-10,11-hydro-5H-dibenzo[a,d] cycloheptene hydrochloride(Aventyl, Pamelor), are given previously in thediscussion of amitriptyline. Metabolic inactivation and eliminationare like those of amitriptyline. Nortriptyline is a selectiveNE transporter (NET) inhibitor.

Biological Activity

ki: 3.4 nm: blocks the norepinephrine transporter.ki: 161 nm: inhibits the serotonin transporter.nortriptyline, a dibenzocycloheptene-derivative tricyclic antidepressant, inhibits norepinephrine and serotonin transporters, which is used for short-term treatment of various forms of depression, including major depression, dysthymia, and atypical depressions. nortriptyline suppresses the norepinephrine presynaptic receptors, thus inhibiting the reuptake of this neurotransmitter and increasing the concentration in the synaptic cleft in the central nervous system.norepinephrine transporter is responsible for the sodium-chloride (na+/cl-) -dependent reuptake of extracellular norepinephrine. serotonin transporter transports serotonin from the synaptic cleft to the presynaptic neuron.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

in vitro

nortriptyline dose-dependently dampened the spontaneous migration of human polymorphonuclear cells (pmn) at the highest concentrations (10-4 and 10-5 m). nortriptyline decreased the motility of the cells at 10-4m. chemotaxis of pmn triggered by 10-10m n-formyl-l-methionil-l-leucyl-l-phenylalanine (fmlp) was blocked by nortriptyline in a dose-dependent fashion [1].

in vivo

rats and mice were injected intraperitoneally with nortriptyline at the dose of 50, 25, 12.5 mg/kg. after 2 hours of the last injection, nortriptyline inducted little or no inhibition of the 4, α-dimethyl-meta-tyramine (h 77/77) induced depletion in a dose of 25 + 12.5 mg/kg. however, there was a partial blockade, evoked by nortriptyline in a dose of 50 + 25 mg/kg, of the h 77/77 elicited depletion in the noradrenaline nerve terminals in all the rats studied. additionally, nortriptyline also proved to be active in the brain, however, its activity was low [2].

References

[1]. sacerdote, p., bianchi, m., & panerai, a. chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. general pharmacology: the vascular system. 1994; 25(3): 409-412.
[2]. carlsson, a., corrodi, h., fuxe, k., & hkfelt, t. effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4, α-dimethyl-meta-tyramine. european journal of pharmacology.1969; 5(4): 367-373.

NORTRIPTYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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NORTRIPTYLINE HYDROCHLORIDE Suppliers

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View Lastest Price from NORTRIPTYLINE HYDROCHLORIDE manufacturers

Dideu Industries Group Limited
Product
NORTRIPTYLINE HCL(USP)(COMING SOON)(P)
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Career Henan Chemical Co
Product
NORTRIPTYLINE HYDROCHLORIDE 894-71-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-24

894-71-3, NORTRIPTYLINE HYDROCHLORIDERelated Search:

Amitriptyline trans-10-Hydroxy Nortriptyline NORTRIPTYLINE NORTRIPTYLINE HYDROCHLORIDE Amitriptyline hydrochloride 10-hydroxyamitriptyline AMITRIPTYLINE-D3 HCL (N-METHYL-D3) DIBENZOSUBEROL Cyclobenzaprine hydrochloride amitriptyline N-oxide Dibenzosuberone DIBENZOSUBERENOL 5-(3-DIMETHYLAMINOPROPYL)-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-OL AMITRIPTYLINE HCL (D6) 10,11-DIHYDRO-5 H-DIBENZO[A,D]CYCLOHEPTENE NORTRIPTYLINE-D3 HYDROCHLORIDE Piroheptine amitriptyline N-glucuronide

  • Nortriptyline Hydrochloride (200 mg)
  • Nortriptyline HCl, 1.0 mg/mL as free base
  • Norzepine
  • Sensival
  • Vividyl
  • NORTRIPTYLINE HCL(P)
  • Norfenazin
  • Nortriptyline hydrochloride solution
  • Nortriptyline for system suitability
  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-ylidene)-N-methyl-, hydrochloride
  • NORTRIPTYLINEHYDROCHLORIDE,USP
  • NORTRIPTYLINE HCL USP
  • Nortriptyline solution hydrochloride
  • 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n-methyl-1-propanamin
  • 5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)dienehydrochloride
  • NORTRIPTYLINE HYDROCHLORIDE
  • NORTRIPTYLINE HCL
  • 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine hydrochloride
  • 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N-methyl-1-propanamine·hydrochloride
  • Nortrityline Hydrochloride
  • (2)10,11-Dihydro-N-methyl-5H-dibenzo[A,D]cycloheptene-.delta.5.gamma.-propylamine, hydrochloride
  • 5-[(3-(Methylamino)propylidene]-10,11-dihydro-5H-dibenzo[A,D]cycloheptene hydrochloride
  • 5-[3-(Methylamino)propylidene]dibenzo[A,D]cyclohepta[1,5]diene hydrochloride
  • 5H-Dibenzo[A,D]cycloheptene-.delta.(sup5),.gamma.-propylamine, 10-11-dihydro-N-methyl-, hydrochloride
  • 5H-Dibenzo[A,D]cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N-methyl-, hydrochloride
  • Acetexa
  • Noramitriptyline hydrochloride
  • Amitriptyline hydrochloride impurity C
  • nortriptyline hydrochloride methanol*solution
  • Amitriptyline EP Impurity C HCl
  • 5-(3-methylaminopropylidene)-10,11-dihydro-5h-dibenzo(a,d)cycloheptenehydroc
  • 5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine,10-11-dihydro-n-met
  • aventylallegron
  • aventylhydrochloride
  • desmethylamitriptylinehydrochloride
  • nortrilen
  • pamelor
  • AMITRIPTYLINE HYDROCHLORIDE IMP C
  • 3-(10, 11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5-YLIDENE)-N-METHYL-1-PROPANAMINE HYDROCHLORIDE
  • Nortriptyline hydrochloride CRS
  • Nortriptyline Hydrochloride &gt
  • Nortriptyline for system suitability CRS
  • Nortriptyline HCl (Amitriptyline EP Impurity C HCl)
  • Amitriptyline EP Impurity C HCl (Nortriptyline HCl)
  • Desitriptyline HCl
  • ELF-101 hydrochloride
  • EN-7048 hydrochloride
  • 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride
  • 10,11-Dihydro-5-(N-methyl-3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene Hydrochloride
  • NORTRIPTYLINE HYDROCHLORIDE USP/EP/BP
  • NORTRIPTYLINE HCL(USP)(COMING SOON)(P) USP/EP/BP
  • Nortriptyline HydrochlorideQ: What is Nortriptyline Hydrochloride Q: What is the CAS Number of Nortriptyline Hydrochloride Q: What is the storage condition of Nortriptyline Hydrochloride Q: What are the applications of Nortriptyline Hydrochloride
  • Amitriptyline Impurity 3
  • Nortriptyline Hydrochloride (1474005)
  • N-Desmethyl Amitriptyline HCl
  • Amitriptyline Hydrochloride EP Impurity C as Hydrochloride
  • Amitriptyline Hydrochloride Impurity C as Hydrochloride
  • 894-71-3