(S)-(-)-1-(4-PYRIDYL)ETHANOL
Reaction- Product Name
- (S)-(-)-1-(4-PYRIDYL)ETHANOL
- CAS No.
- 54656-96-1
- Chemical Name
- (S)-(-)-1-(4-PYRIDYL)ETHANOL
- Synonyms
- 4-AMINOIMIDAZOLE 2HCL;Propanoicacid,5-methoxy-;(1S)-1-(4-pyridyl)ethanol;(S)-1-(pyridin-4-yl)ethanol;(S)-(-)-1-(4-PYRIDYL)ETHANOL;4-[(S)-1-Hydroxyethyl]pyridine;(S)-1-(pyridin-4-yl)ethan-1-ol;(S)-4-(1-HYDROXYETHYL) PYRIDINE;(S)-α-Methylpyridine-4-methanol;(αS)-α-Methylpyridine-4-methanol
- CBNumber
- CB8219787
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 54656-96-1.mol
(S)-(-)-1-(4-PYRIDYL)ETHANOL Property
- Melting point:
- 67-69 °C(lit.)
- Boiling point:
- 239.7±15.0 °C(Predicted)
- Density
- 1.082±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- soluble in Methanol
- pka
- 13.52±0.20(Predicted)
- form
- Needles
- color
- White
- optical activity
- [α]20/D 58°, c = 1 in chloroform
- BRN
- 1524527
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 448540
- Product name
- (S)-(?)-α-Methyl-4-pyridinemethanol
- Purity
- 99%
- Packaging
- 1g
- Price
- $493
- Updated
- 2023/01/07
- Product number
- H1734
- Product name
- (S)-4-(1-Hydroxyethyl)pyridine
- Packaging
- 1G
- Price
- $94
- Updated
- 2025/07/31
- Product number
- H1734
- Product name
- (S)-4-(1-Hydroxyethyl)pyridine
- Packaging
- 5G
- Price
- $280
- Updated
- 2025/07/31
- Product number
- 07-1161
- Product name
- (S)-(-)-α-Methyl-4-pyridinemethanol, min. 98%
- Packaging
- 50mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 07-1161
- Product name
- (S)-(-)-α-Methyl-4-pyridinemethanol, min. 98%
- Packaging
- 100mg
- Price
- $111
- Updated
- 2024/03/01
(S)-(-)-1-(4-PYRIDYL)ETHANOL Chemical Properties,Usage,Production
Reaction
- Used for the synthesis of chiral 1-(4-pyridinyl)ethylamines
- Precursor for intermediates of highly stable chiral (A)6-B Supramolecular Copolymers
Chemical Properties
White needles
Uses
(S)?-?(-?)?-?1-?(4-?Pyridyl)?ethanol is a building block used in the synthesis of macrocycles which act as hydrogenation catalysts as well as other pharmaceutical agents
Synthesis
1122-54-9
54656-96-1
The general procedure for the synthesis of (S)-4-pyridine-1-ethanol from 4-acetylpyridine was as follows: first, the relative activities of the 26 substrates were assessed by a previously described assay protocol and the enzyme-to-substrate concentration ratio was adjusted. In this procedure, the activity of α-chloroacetophenone was used as a benchmark (set at 100%). Subsequently, the reduction reaction of aromatic ketones was determined enantioselectively using a NADH regeneration system consisting of KcDH purified from Bacillus subtilis CGMCC 1.1398 and glucose dehydrogenase (GDH). The specific reaction conditions were as follows: 0.5 mM NAD+, 10 mM ketone substrate, 1 U KcDH, 50 mg glucose, and 2 U GDH were added to 1 mL of 50 mM potassium phosphate buffer (pH 7.0). the reaction was carried out for 16 h. After the reaction was carried out, the reaction mixture was homogenized into two parts. One portion was terminated by adding an equal volume of methanol and subsequently analyzed by HPLC to determine the conversion; the other portion was extracted with ethyl acetate and further analyzed for enantiomeric excess (ee). The chiral products were analyzed by HPLC or GC methods, and the specific operating conditions are detailed in Supplementary Table S1.
Purification Methods
Purify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]
References
[1] Organic Letters, 2000, vol. 2, # 12, p. 1749 - 1751
[2] Synthesis, 2009, # 14, p. 2413 - 2417
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 10, p. 2293 - 2302
[4] Tetrahedron Asymmetry, 2002, vol. 13, # 20, p. 2201 - 2204
[5] Advanced Synthesis and Catalysis, 2016, vol. 358, # 24, p. 4006 - 4018
(S)-(-)-1-(4-PYRIDYL)ETHANOL Preparation Products And Raw materials
Raw materials
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View Lastest Price from (S)-(-)-1-(4-PYRIDYL)ETHANOL manufacturers
- Product
- (s)-(-)-1-(4-pyridyl)ethanol 54656-96-1
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- (S)-(-)-1-(4-PYRIDYL)ETHANOL 54656-96-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- (S)-(-)-1-(4-PYRIDYL)ETHANOL 54656-96-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27