ChemicalBook > CAS DataBase List > (S)-(-)-1-(4-PYRIDYL)ETHANOL

(S)-(-)-1-(4-PYRIDYL)ETHANOL

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Product Name: (S)-(-)-1-(4-PYRIDYL)ETHANOL
CAS No.: 54656-96-1
Chemical Name: (S)-(-)-1-(4-PYRIDYL)ETHANOL
Synonyms: 4-AMINOIMIDAZOLE 2HCL;Propanoicacid,5-methoxy-;(1S)-1-(4-pyridyl)ethanol;(S)-1-(pyridin-4-yl)ethanol;(S)-(-)-1-(4-PYRIDYL)ETHANOL;4-[(S)-1-Hydroxyethyl]pyridine;(S)-1-(pyridin-4-yl)ethan-1-ol;(S)-4-(1-HYDROXYETHYL) PYRIDINE;(S)-α-Methylpyridine-4-methanol;(αS)-α-Methylpyridine-4-methanol
CBNumber: CB8219787
Molecular Formula: C7H9NO
Formula Weight: 123.15
MOL File: 54656-96-1.mol

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(S)-(-)-1-(4-PYRIDYL)ETHANOL Property

Melting point:: 67-69 °C(lit.)
Boiling point:: 239.7±15.0 °C(Predicted)
Density: 1.082±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: soluble in Methanol
pka: 13.52±0.20(Predicted)
form: Needles
color: White
optical activity: [α]20/D 58°, c = 1 in chloroform
BRN: 1524527

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 448540
Product name: (S)-(?)-α-Methyl-4-pyridinemethanol
Purity: 99%
Packaging: 1g
Price: $493
Updated: 2023/01/07

TCI Chemical

Product number: H1734
Product name: (S)-4-(1-Hydroxyethyl)pyridine
Packaging: 1G
Price: $94
Updated: 2025/07/31

TCI Chemical

Product number: H1734
Product name: (S)-4-(1-Hydroxyethyl)pyridine
Packaging: 5G
Price: $280
Updated: 2025/07/31

Strem Chemicals

Product number: 07-1161
Product name: (S)-(-)-α-Methyl-4-pyridinemethanol, min. 98%
Packaging: 50mg
Price: $70
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1161
Product name: (S)-(-)-α-Methyl-4-pyridinemethanol, min. 98%
Packaging: 100mg
Price: $111
Updated: 2024/03/01

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(S)-(-)-1-(4-PYRIDYL)ETHANOL Chemical Properties,Usage,Production

Reaction

Used for the synthesis of chiral 1-(4-pyridinyl)ethylamines
Precursor for intermediates of highly stable chiral (A)6-B Supramolecular Copolymers

Chemical Properties

White needles

Uses

(S)?-?(-?)?-?1-?(4-?Pyridyl)?ethanol is a building block used in the synthesis of macrocycles which act as hydrogenation catalysts as well as other pharmaceutical agents

Synthesis

1122-54-9

54656-96-1

The general procedure for the synthesis of (S)-4-pyridine-1-ethanol from 4-acetylpyridine was as follows: first, the relative activities of the 26 substrates were assessed by a previously described assay protocol and the enzyme-to-substrate concentration ratio was adjusted. In this procedure, the activity of α-chloroacetophenone was used as a benchmark (set at 100%). Subsequently, the reduction reaction of aromatic ketones was determined enantioselectively using a NADH regeneration system consisting of KcDH purified from Bacillus subtilis CGMCC 1.1398 and glucose dehydrogenase (GDH). The specific reaction conditions were as follows: 0.5 mM NAD+, 10 mM ketone substrate, 1 U KcDH, 50 mg glucose, and 2 U GDH were added to 1 mL of 50 mM potassium phosphate buffer (pH 7.0). the reaction was carried out for 16 h. After the reaction was carried out, the reaction mixture was homogenized into two parts. One portion was terminated by adding an equal volume of methanol and subsequently analyzed by HPLC to determine the conversion; the other portion was extracted with ethyl acetate and further analyzed for enantiomeric excess (ee). The chiral products were analyzed by HPLC or GC methods, and the specific operating conditions are detailed in Supplementary Table S1.

Purification Methods

Purify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]

References

[1] Organic Letters, 2000, vol. 2, # 12, p. 1749 - 1751
[2] Synthesis, 2009, # 14, p. 2413 - 2417
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 10, p. 2293 - 2302
[4] Tetrahedron Asymmetry, 2002, vol. 13, # 20, p. 2201 - 2204
[5] Advanced Synthesis and Catalysis, 2016, vol. 358, # 24, p. 4006 - 4018

(S)-(-)-1-(4-PYRIDYL)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-(-)-1-(4-PYRIDYL)ETHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (s)-(-)-1-(4-pyridyl)ethanol 54656-96-1
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Shaanxi Dideu Medichem Co. Ltd

Product: (S)-(-)-1-(4-PYRIDYL)ETHANOL 54656-96-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-(-)-1-(4-PYRIDYL)ETHANOL 54656-96-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

54656-96-1, (S)-(-)-1-(4-PYRIDYL)ETHANOLRelated Search:

QUININE FORMATE CINCHONIDINE SULFATE Diphenyl(4-pyridyl)methanol QUININE SULFATE Cinchonidine (S)-(-)-1-(4-PYRIDYL)ETHANOL QUININE VALERATE N-Benzylcinchonidinium chloride MESO-ALPHA,BETA-DI(4-PYRIDYL) GLYCOL 1-(3-FLUORO-2-PYRIDYL)ETHANOL (S)-1-(3-PYRIDYL)ETHANOL,(1S)-1-(3-Pyridyl)ethanol (6-ETHOXYPYRIDIN-3-YL)BORONIC ACID 2-tert-Butylamino-1-(5-hydroxy-6-hydroxymethyl-2-pyridyl)ethanol 2-(2-Hydroxyethyl)pyridine, 2-(2-Pyridyl)ethanol,2-(alpha-pyridyl)ethano (S)-1-(2-PYRIDYL)ETHANOL,(1S)-1-(2-Pyridyl)ethanol,(S)-1-(2-Pyridyl)ethanol, (S)-2-(1-Hydroxyethyl)pyridine (R)-1-(2-Pyridyl)-ethanol, (R)-2-(1-Hydroxyethyl)pyridine,(R)-1-(2-PYRIDYL)-ETHANOL Quinine hydrochloride CINCHONIDINE HYDROCHLORIDE

(S)-(-)-ALPHA-METHYL-4-PYRIDINEMETHANOL, 99% (98% EE/GLC)

(S)-4-(1-Hydroxyethyl)pyridine, (99+% ee), 99+%

(S)-(-)-1-(4-PYRIDYL)ETHANOL

(S)-4-(1-HYDROXYETHYL) PYRIDINE

(S)-(-)-ALPHA-METHYL-4-PYRIDINEMETHANOL

(s)-(-)-α-methyl-4-pyridinemethanol

4-AMINOIMIDAZOLE 2HCL

(S)-4-(1-Hydroxyethyl)pyridine, (99+% ee)

(S)-α-Methylpyridine-4-methanol

(αS)-α-Methylpyridine-4-methanol

4-[(S)-1-Hydroxyethyl]pyridine

(S)-4-(1-Hydroxyethyl)pyridine,99+%,(99+% ee)

(aS)-a-Methyl-4-PyridineMethanol

(S)-1-(pyridin-4-yl)ethanol

(S)-1-(pyridin-4-yl)ethan-1-ol

(αS)-α-Methyl-4-pyridinemethanol,99%e.e.

(S)-(-)-Α-METHYL-4-PYRIDINEMETHANOL,MIN.98%

(S)-(-)-α-Methyl-4-pyridinemethanol, min. 98%

(S)-1-(pyridin-4-yl)ethan-1-ol54656-96-1

4-Pyridinemethanol, α-methyl-, (αS)-

4-Pyridinemethanol,α-methyl-,(αS)-

(S)-(-)-1-(4-PYRIDYL)ETHANOL ISO 9001：2015 REACH

(αS)-α-Methyl-4-pyridinemethanol

(1S)-1-(4-pyridyl)ethanol

Propanoicacid,5-methoxy-

(<i>S</i>)-(?)-α-Methyl-4-pyridinemethanol

(S)-(-)-α-Methyl-4-pyridinemethanol, CAS 54656-96-1

54656-96-1

Chiral Resolving Reagents

Chiral Resolution Reagents

Asymmetric Synthesis

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds