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2,3-Di-O-para-toluoyl-D-tartaric acid

Product Name
2,3-Di-O-para-toluoyl-D-tartaric acid
CAS No.
32634-68-7
Chemical Name
2,3-Di-O-para-toluoyl-D-tartaric acid
Synonyms
D-DTTA;DI-P-TOLUOYL-D-TARTARIC ACID;D-PTTA;RivastigMine Related CoMpound A;(+)-DTTA;2,3-Di-O-para-toluoy;Letomovir impurity D;RivastigMine USP RC A;toluoyl-tartaric acid;Citalopram Impurity 43
CBNumber
CB8225287
Molecular Formula
C20H18O8
Formula Weight
386.35
MOL File
32634-68-7.mol
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2,3-Di-O-para-toluoyl-D-tartaric acid Property

Melting point:
169-171 °C(lit.)
alpha 
136 º (c=1, EtOH)
Boiling point:
432.57°C (rough estimate)
Density 
1.3084 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
139 ° (C=1, EtOH)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly)
form 
Solid
pka
1.46±0.25(Predicted)
color 
White to Off-White
optical activity
[α]19/D +138°, c = 1 in ethanol
Water Solubility 
112.55mg/L at 25℃
BRN 
3225584
LogP
2.97 at 25℃
CAS DataBase Reference
32634-68-7(CAS DataBase Reference)
NIST Chemistry Reference
(+)-Di-o-4-toluoyl-d-tartaric acid(32634-68-7)
EPA Substance Registry System
Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)- (32634-68-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37-26
WGK Germany 
3
F 
3-10
TSCA 
T
HS Code 
29181300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
302813
Product name
(+)-O,O′-Di-p-toluoyl-D-tartaric acid
Purity
made from synthetic tartaric acid, 97%
Packaging
25g
Price
$118.3
Updated
2025/07/31
Sigma-Aldrich
Product number
1604869
Product name
Rivastigmine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1200
Updated
2025/07/31
TCI Chemical
Product number
D1417
Product name
(+)-Di-p-toluoyl-D-tartaric Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
D1417
Product name
(+)-Di-p-toluoyl-D-tartaric Acid
Purity
>98.0%(HPLC)(T)
Packaging
250g
Price
$141
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR2029
Product name
Rivastigmine Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
30mg
Price
$425.6
Updated
2025/07/31
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2,3-Di-O-para-toluoyl-D-tartaric acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

blood volume expander

Uses

Inhibitor of enzyme. Rivastigmine USP Related Compound A.

Flammability and Explosibility

Not classified

Synthesis

72842-25-2

32634-68-7

General procedure for the synthesis of D-(+)-di-p-toluoyltartaric acid from L-(-)-p-toluoyltartaric anhydride: 150 g of D-tartaric acid and 200 mL of toluene were added to a 1000 mL three-necked flask, and 1.5 g of copper sulfate was added as a catalyst under stirring conditions. 330 g of methylbenzoyl chloride was slowly added dropwise for a controlled period of 3 hours. After the dropwise addition, the reaction was continued for 6 hours. Upon completion of the reaction, the mixture was transferred to a centrifuge for separation. Next, 495.4 g of DP-methyldibenzoyltartaric anhydride, appropriate amount of water and toluene were added to a 2000 mL three-necked flask, heated to reflux and kept for 5 hours. At the end of the reaction, it was cooled to room temperature and 374.4 g of DP-methyldibenzoyltartaric acid was isolated. The product was used for TEM test and its structure is shown in Figure 1. The purity of the finished product D-p-methyldibenzoyltartaric acid was determined to be 99.61% with an overall yield of 96.6%.

References

[1] Patent: CN104447338, 2016, B. Location in patent: Paragraph 0034-0036

2,3-Di-O-para-toluoyl-D-tartaric acid Preparation Products And Raw materials

Raw materials

Preparation Products

CARUMONAM
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2,3-Di-O-para-toluoyl-D-tartaric acid Suppliers

Americas 1 Belgium 1 Canada 2 China 405 Europe 5 France 3 Germany 9 Hungary 2 India 57 Italy 1 Japan 5 Poland 1 Slovakia 1 South Korea 2 Switzerland 3 United Kingdom 23 United States 56 Global 577
Acros Organics
Tel
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Fax
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Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
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View Lastest Price from 2,3-Di-O-para-toluoyl-D-tartaric acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
(+)-Di-p-toluoyl-D-tartaric acid 32634-68-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10000kg
Release date
2021-11-03
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,3-Di-O-para-toluoyl-D-tartaric acid 32634-68-7
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Henan Aochuang Chemical Co.,Ltd.
Product
2,3-Di-O-para-toluoyl-D-tartaric acid 32634-68-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14

32634-68-7, 2,3-Di-O-para-toluoyl-D-tartaric acidRelated Search:

(-)-Di-p-toluoyl-L-tartaric acid Di-p-toluoyl-D-tartaric acid monohydrate DL-Malic acid (+)-Dibenzoyl-D-tartaric acid monohydrate Di-p-anisoyl-L-tartaric acid (-)-Dibenzoyl-L-tartaric acid monohydrate Dibenzoyl-L-tartaric acid (+)-Dibenzoyl-D-tartaric acid Dibenzoyltartaric acid tert-Butanesulfinamide D-Tartaric acid 2,3-Di-O-para-toluoyl-D-tartaric acid 4-[(1S)-(4-Dimethylamino)-1-(4-fluotophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid (+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT R-VENLAFAXINE-DI-P-TOLUOYL-D-TARTRATE SALT

  • RivastigMine USP RC A
  • RivastigMine Related CoMpound A
  • D- twoMethylbenzoyltartaric acid
  • (+)-2,3-Di-p-toluoyl-D-tartaric acid
  • (+)-Di-<i>p-</i>toluoyl-D-tartaric acid
  • D - 2 Methyl benzoyl tartaric acid
  • (+)-Di-1,4-toluoyl-D-tartaric acid [S(R*,R*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid
  • (+)- Ditoluoyltartaric acid
  • (2S,3S)-(+)-di-O-(p-toluoyl)-tartaric acid
  • Di-p-toluoyl-D-tartaric Acid,99%e.e.
  • (2S,3S)-(+)-Di-O-4-toluoyl-D-tartaric acid for synthesis
  • (-)-di-p-Toluyl-L-tartaric acid
  • D-DTTA
  • DI-(4-METHYL)BENZOYL-D-TARTARIC ACID
  • (+)-DTTA
  • D-(+)-TARTARIC ACID-O,O'-DI-P-TOLUOYL ESTER
  • D-(+)-TARTARIC ACID DI-4-TOLUOYL ESTER
  • D-PTTA
  • DI-P-TOLUOYL-D-TARTARIC ACID
  • (+)-DI-P-TOLUOYL-D-TRATARIC ACID
  • DI-O-4-TOLUOYL-D-TARTARIC ACID
  • (+)-DI-O,O'-P-TOLUYL-D-TARTARIC ACID
  • [s(r*,r*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid
  • O,O'-DI-TOLUOYL-D-(+)-TARTARIC ACID
  • (+)-O,O'-DI-P-TOLUOYL-D-TARTARIC ACID
  • O,O'-DI-P-TOLUOYL-D-TARTARIC ACID
  • Di-p-Toluoyl-D-Tartaric Acid Anhydrate
  • Di-4-Toluoyl-D-tartaric acid
  • DI-P-TOLUOYL-D-TARTARIC ACID, 97%, MADE FROM UNNATURAL TARTARIC ACID
  • DI-P-Toluoyl-D-Tartaric Acid Anhydrous
  • Di-Para-Toluoyl-D-TartaricAcid
  • Di-Para-Toluoyl-L-TartaricAcid,Anhydrous
  • (+)-DI-P-TOLUOYL-D-TARTARIC ACID D-(+)-DTTA 99%
  • Di-p-Toluoyl-D-tartaric
  • DI-P-TOLUOYL-D-TARTARIC ACID\ S-(-)-TERT-BUTANESULFINAMIDE
  • (+)-DI-O,O''-P-TOLUYL-D-WEINSURE
  • (+)-Di-p-toluyl-D-tartaric acid
  • toluoyl-tartaric acid
  • DI-P-TOTUOYL-D-TARTARIC ACID
  • 3-hydroxy-2-[(2-methylphenyl)-oxomethoxy]-2-[(2-methylphenyl)-oxomethyl]butanedioic acid
  • (-)-Nicotine (+)-O,O&rsquo
  • (+)-Di-1,4-toluoyl-D-tartaric acid(DDTTA)
  • (S,S)-O,O'-Di-p-toluoyltartaric acid
  • p-Toluic acid, diester with D-tartaric acid (7CI)
  • Tartaric acid, di-p-toluate, (+)- (8CI)
  • Rivastigmine Related Compound A (15 mg) ((+)-Di-p-toluoyl-D-(+)-tartaric acid)
  • (2S,35)-(-)-di-o-4-Toluoyl-D-tartaric acid
  • 2,3-bis[(4-methylbenzoyl)oxy]-,[s-(theta,theta)]-butanedioicaci
  • 2,3-Bis[(4-methylbenzoyl)oxy]succinic acid
  • 2,3-DI-O-PARA-TOLUOYL-D-TARTARICACIDHYDRATE
  • Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, [S-(R*,R*)]-
  • L-di-p-Toluyltartaric acid
  • 2,3-Di-O-para-toluoyl-D-tartaric acid
  • (2S,3S)-2,3-BIS-(4-METHYL-BENZOYLOXY)-SUCCINIC ACID
  • (2S,3S)-(+)-DI-O-4-TOLUOYL-TARTARIC ACID
  • D-(+)-DI-P-TOLUOYL TARTARIC ACID
  • (+)-O,O'-Di-1,4-toluoyl-D-tartaric acid
  • L-(-)-DI-P-TOLUOYL-D-TARTARIC ACID